Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background The renin‐angiotensin system plays a crucial role in human physiology, and its main hormone, angiotensin, activates 2 G‐protein–coupled receptors, the angiotensin type‐1 and type‐2 receptors, in almost every organ.
Caglar Cosarderelioglu +12 more
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Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists [PDF]
Biomolecules, 2020 Angiotensin II receptor type 1 and 2 (AT1R and AT2R) are two G-protein coupled receptors that mediate most biological functions of the octapeptide Angiotensin II (Ang II).
Silvana Vasile +5 more
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Frontiers in Endocrinology, 2022 The angiotensin type 2 (AT2) receptor and the bradykinin type 2 (B2) receptor are G protein-coupled receptors (GPCRs) that have major roles in the cardiovascular system. The two receptors are known to functionally interact at various levels, and there is
Elizabeth K. M. Johnstone +15 more
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Angiotensin Type 2 Receptor-Mediated Hypotension in Angiotensin Type-1 Receptor-Blocked Rats [PDF]
Hypertension, 2001 The type-2 (AT 2 ) angiotensin (Ang) II receptor has been characterized as potentially counterregulatory to the actions of Ang II at its type-1 (AT 1 ) receptor. We investigated the effects of Ang II and CGP-42112A (CGP), a selective peptide AT
R M, Carey +3 more
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The effect of aerobic exercise on the function of the local renin-angiotensin system and gluconeogenesis pathway in the liver tissue of type 2 diabetic rats [PDF]
مجله علوم پزشکی فیض (پیوسته), 2023 Background and Aim: One of the important and effective physiological systems in the pathogenesis of type 2 diabetes is the local renin-angiotensin system. The aim of the current study was to determine the effect of aerobic exercise on the function of the
Mohadeseh Shojaei +2 more
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Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?
Molecular Medicine, 2020 Infection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin II type 1 receptor and, on the other hand, stimulation of the angiotensin II type 2 receptor and/
Pawel Namsolleck, Gert N. Moll
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Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor–Mediated Cardiomyocyte Autophagy [PDF]
Hypertension, 2009 Autophagy has emerged as an important process in the pathogenesis of cardiovascular diseases, but the proximal triggers for autophagy are unknown. Angiotensin II plays a central role in the pathogenesis of cardiac hypertrophy and heart failure. In this study, we used angiotensin II type 1 (AT 1 ) and type 2 (AT
Porrello, Enzo R. +6 more
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Angiotensin Type 2 Receptor Stimulation Ameliorates Left Ventricular Fibrosis and Dysfunction via Regulation of Tissue Inhibitor of Matrix Metalloproteinase 1/Matrix Metalloproteinase 9 Axis and Transforming Growth Factor β1 in the Rat Heart [PDF]
, 2014 Left ventricular (LV) remodeling is the main reason for the development of progressive cardiac dysfunction after myocardial infarction (MI). This study investigated whether stimulation of the angiotensin type 2 receptor is able to ameliorate
Dahlöf, Bjorn +10 more
core +7 more sources
Biomedicines, 2023 The present study examined the underlying mechanisms of mechanical allodynia and thermal hyperalgesia induced by the intracisternal injection of angiotensin (Ang) II.
Ki-Don Park +8 more
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Frontiers in Pharmacology, 2020 G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved and clinical prescribed drugs and represent the largest and most structurally diverse family of transmembrane signaling proteins, with almost 1000 members ...
Natalia L. Rukavina Mikusic +3 more
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