Results 111 to 120 of about 268,869 (312)

Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System

Frontiers in Cell and Developmental Biology, 2020
The emergence of SARS-CoV-2/human/Wuhan/X1/2019, a virus belonging to the species Severe acute respiratory syndrome-related coronavirus, and the recognition of Coronavirus Disease 2019 (COVID-19) as a pandemic have highly increased the scientific ...
Larissa Braga Costa, Lucas Giandoni Perez, Vitória Andrade Palmeira, Thiago Macedo e Cordeiro, Victor Teatini Ribeiro, Katharina Lanza, Ana Cristina Simões e Silva   +6 more
doaj   +1 more source

Natriuretic peptides and cardiovascular damage in the metabolic syndrome. Molecular mechanisms and clinical implications [PDF]

, 2010
Natriuretic peptides are endogenous antagonists of vasoconstrictor and salt- and water-retaining systems in the body's defence against blood pressure elevation and plasma volume expansion, through direct vasodilator, diuretic and natriuretic properties ...
ALONZO, ALESSANDRO, Rossi C, RUBATTU, Speranza Donatella, SAVOIA, Carmine, VOLPE, Massimo   +4 more
core   +1 more source

Angiotensin II type 2 receptor stimulation

, 2014
Background This study is the first to examine the effect of direct Ang II type 2 (AT2) receptor stimulation on post infarct cardiac function with the use of the novel nonpeptide AT2 receptor agonist compound 21 (C21). Methods and Results Myocardial infarction (MI) was induced in Wistar rats by permanent ligation of the left coronary artery.
openaire   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Impaired angiotensin II signaling in septic shock

Annals of Intensive Care
Recent years have seen a resurgence of interest for the renin–angiotensin–aldosterone system in critically ill patients. Emerging data suggest that this vital homeostatic system, which plays a crucial role in maintaining systemic and renal hemodynamics ...
Adrien Picod, Bruno Garcia, Dirk Van Lier, Peter Pickkers, Antoine Herpain, Alexandre Mebazaa, Feriel Azibani   +6 more
doaj   +1 more source

IRBIT a Master Regulator of Cell Physiology [PDF]

, 2017
(excerpt) Hormones and neurotransmitters regulate cell functions by binding to their receptors, which activate intracellular signaling and produce the physiological response [1].
Bouyer, Patrice G, Cook, Kelli, Petreska, Natasa   +2 more
core   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

The angiotensin II type 2 receptor in cardiovascular disease

Journal of the Renin-Angiotensin-Aldosterone System, 2009
Angiotensin II (Ang II) is considered the major final mediator of the renin-angiotensin system. The actions of Ang II have been implicated in many cardiovascular conditions, such as hypertension, atherosclerosis, coronary heart disease, restenosis, and heart failure.
Catherine A, Lemarié, Ernesto L, Schiffrin   +1 more
openaire   +2 more sources

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Roles of Brain Angiotensin II in Cognitive Function and Dementia

International Journal of Hypertension, 2012
The brain renin-angiotensin system (RAS) has been highlighted as having a pathological role in stroke, dementia, and neurodegenerative disease. Particularly, in dementia, epidemiological studies indicate a preventive effect of RAS blockade on cognitive ...
Masaki Mogi, Jun Iwanami, Masatsugu Horiuchi   +2 more
doaj   +1 more source