Results 41 to 50 of about 270,851 (310)
Neuroprotective effect of angiotensin II type 2 receptor during cerebral ischemia/reperfusion
Neural Regeneration Research, 2016 Angiotensin II type 2 receptor (AT2R) activation has been shown to protect against stroke, but its precise mechanism remains poorly understood. We investigated whether the protective effect of AT2R against ischemia/reperfusion injury is mediated by the ...
Chun-ye Ma, Lin Yin
doaj +1 more source
Angiotensin type-2 (AT-2)-receptor activation reduces renal fibrosis in cyclosporine nephropathy: evidence for blood-pressure independent effect [PDF]
, 2016 Compound 21 (C21), selective agonist of AT2 receptors, shows antinflammatory effects in hypertension and nephroprotection in diabetes. The aim of this study was to evaluate the effects of C21 in cyclosporine nephropathy, which is characterized mainly by ...
Carletti, R +5 more
core +1 more source
Clinics, 2014 OBJECTIVE: To validate the importance of the angiotensin II receptor isotypes and the lymphatic vessels in systemic sclerosis and idiopathic pulmonary fibrosis.
Edwin Roger Parra +2 more
doaj +1 more source
Angiotensin type 2 receptors: blood pressure regulation and end organ damage [PDF]
Current Opinion in Pharmacology, 2015 In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of AT2R locally within the brain or the
Sumners, Colin +4 more
openaire +3 more sources
Direct angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPARγ activation. [PDF]
PLoS ONE, 2012 ObjectivesThe role of angiotensin II type 2 (AT(2)) receptor stimulation in the pathogenesis of insulin resistance is still unclear. Therefore we examined the possibility that direct AT(2) receptor stimulation by compound 21 (C21) might contribute to ...
Kousei Ohshima +11 more
doaj +1 more source
Cardiovascular effects of the angiotensin type 2 receptor
Revista Portuguesa de Cardiologia (English Edition), 2014 The angiotensin type 2 receptor, AT2R, has been described as having opposite effects to the angiotensin type 1 receptor, AT1R. Although the quantities of the AT2R found in the adult are low, its expression rises in pathological situations. The AT2R has three major signaling pathways: activation of serine/threonine phosphatases (promoting apoptosis and ...
Gabriel, Faria-Costa +2 more
openaire +2 more sources
Macrophage angiotensin II type 2 receptor triggers neuropathic pain [PDF]
Proceedings of the National Academy of Sciences, 2018 SignificanceNeuropathic pain is a widespread problem that is undermanaged by currently available analgesic drugs. An antagonist of the type II angiotensin II receptor (AT2R) reduces pain behaviors related to neuropathy, suggesting that angiotensin receptor signaling is involved in this pain.
Andrew J. Shepherd +10 more
openaire +2 more sources
The Angiotensin II Type 2 Receptor in Brain Functions: An Update
International Journal of Hypertension, 2012 Angiotensin II (Ang II) is the main active product of the renin-angiotensin system (RAS), mediating its action via two major receptors, namely, the Ang II type 1 (AT1) receptor and the type 2 (AT2) receptor.
Marie-Odile Guimond, Nicole Gallo-Payet
doaj +1 more source
The Angiotensin II Type 2 Receptor for Pain Control [PDF]
Cell, 2014 All well-known deleterious effects of angiotensin (Ang) II, including vasoconstriction, inflammation, water and salt retention, and vascular remodeling, are mediated via its type 1 (AT1) receptor. This explains why AT1 receptor blockers (ARBs) and inhibitors of Ang II synthesis, such as ACE inhibitors and renin inhibitors, are beneficial for ...
Danser, Jan, Anand, P
openaire +3 more sources
Cells, 2021 Evidence has arisen in recent years suggesting that a tissue renin-angiotensin system (tRAS) is involved in the progression of various human diseases. This system contains two regulatory pathways: a pathological pro-inflammatory pathway containing the ...
Babak Saravi +10 more
doaj +1 more source