Results 21 to 30 of about 17,282 (158)

Mechanism of the Interaction of Cannabinoid System in Central Amygdale with Opioid System [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2008
Background and objectives Cannabinoids which are active compounds of marijuana show some pharmacological effects similar to the opioids. There are also functional interactions between both cannabinoid and opioid systems. In this study we investigated the
SH Sarahroodi, A Arzi, MR Zarrindast, MJ Khodayar   +3 more
doaj   +1 more source

Cannabinoid Receptor Activation Disrupts the Internal Structure of Hippocampal Sharp Wave–Ripple Complexes

Journal of Pharmacological Sciences, 2012
Cannabinoid agonists impair hippocampus-dependent learning and memory. Using mouse hippocampal slice preparations, we examined the effect of anandamide, an endogenous cannabinoid, on sharp wave–ripple (SW-R) complexes, which are believed to mediate ...
Yi Sun, Hiroaki Norimoto, Xiao-Ping Pu, Norio Matsuki, Yuji Ikegaya   +4 more
doaj   +1 more source

New Perspectives in the Studies on Endocannabinoid and Cannabis: Cannabinoid Receptors and Schizophrenia

Journal of Pharmacological Sciences, 2004
Cannabis consumption may induce psychotic states in normal individuals, worsen psychotic symptoms of schizophrenic patients, and may facilitate precipitation of schizophrenia in vulnerable individuals.
Hiroshi Ujike, Yukitaka Morita
doaj   +1 more source

Signal transduction of the CB1 cannabinoid receptor [PDF]

Journal of Molecular Endocrinology, 2009
The CB1 cannabinoid receptor (CB1R) is the major cannabinoid receptor in neuronal cells and the brain, but it also occurs in endocrine cells and other peripheral tissues. CB1R is a member of the superfamily of G-protein-coupled receptors (GPCRs), which are characterized by seven transmembrane helices.
Gábor, Turu, László, Hunyady
openaire   +2 more sources

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. [PDF]

PLoS ONE, 2008
Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation.
Blerina Kola, Imre Farkas, Mirjam Christ-Crain, Gábor Wittmann, Francesca Lolli, Faisal Amin, Judith Harvey-White, Zsolt Liposits, George Kunos, Ashley B Grossman, Csaba Fekete, Márta Korbonits   +11 more
doaj   +1 more source

Differential expression of brain cannabinoid receptors between repeatedly stressed males and females may play a role in age and gender-related difference in traumatic brain injury: Implications from animal studies

Frontiers in Neurology, 2014
Inconsistent gender differences in the outcome of TBI have been reported. The mechanism is unknown. In a recent male animal study, repeated stress followed by TBI had synergistic effects on brain gene expression and caused greater behavioral deficits ...
Guoqiang eXing, Guoqiang eXing, Janis eCarlton, Xiaolong eJiang, Jillian eWen, Jillian eWen, Min eJia, He eLi   +7 more
doaj   +1 more source

Indomethacin plus minocycline coadministration relieves chemotherapy and antiretroviral drug-induced neuropathic pain in a cannabinoid receptors-dependent manner

Journal of Pharmacological Sciences, 2019
Neuropathic pain sometimes occurs during chemotherapy with paclitaxel or HIV/AIDS antiretroviral therapy with nucleoside reverse transcriptase inhibitors (NRTIs).
Willias Masocha, Amal Thomas
doaj   +1 more source

Brodifacoum does not modulate human cannabinoid receptor-mediated hyperpolarization of AtT20 cells or inhibition of adenylyl cyclase in HEK 293 cells [PDF]

PeerJ, 2019
Background Synthetic cannabinoids are a commonly used class of recreational drugs that can have significant adverse effects. There have been sporadic reports of co-consumption of illicit drugs with rodenticides such as warfarin and brodifacoum (BFC) over
Shivani Sachdev, Rochelle Boyd, Natasha L. Grimsey, Marina Santiago, Mark Connor   +4 more
doaj   +2 more sources

Suicide attempt and paranoia persisting for 28 days following heavy delta-9-tetrahydrocannabinolic acid and tetrahydrocannabinol use: A case report. [PDF]

PCN Rep
Abstract Background Cannabis contains various cannabinoids, with Δ9‐tetrahydrocannabinol (Δ9‐THC) being the primary psychoactive compound. A non‐psychoactive precursor called Δ9‐tetrahydrocannabinolic acid (THC‐A) is converted to Δ9‐THC slowly over time or rapidly when heated. Cannabis use is linked to psychotic outcomes, with increased risk associated
Greer D, Dey P, Kulig CE.
europepmc   +2 more sources

Novel Adamantyl Cannabinoids as CB1 Receptor Probes [PDF]

Journal of Medicinal Chemistry, 2013
In previous studies, compound 1 (AM411), a 3-(1-adamantyl) analogue of the phytocannabinoid (-)-Δ(8)-tetrahydrocannabinol (Δ(8)-THC), was shown to have improved affinity and selectivity for the CB1 receptor. In this work, we further explored the role of the 1-adamantyl group at the C-3 position in a series of tricyclic cannabinoid analogues modified at
Ganesh A, Thakur, Shama, Bajaj, Carol, Paronis, Yan, Peng, Anna L, Bowman, Lawrence S, Barak, Marc G, Caron, Demon, Parrish, Jeffrey R, Deschamps, Alexandros, Makriyannis   +9 more
openaire   +2 more sources