Results 71 to 80 of about 53,933 (241)

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

A novel role for farnesoid X receptor in the bile acid‐mediated intestinal glucose homeostasis

Journal of Cellular and Molecular Medicine, 2020
The farnesoid X receptor (FXR), as a bile acid (BA) sensor, plays an important role in the regulation of lipid metabolism. However, the effects and underlying molecular mechanisms of FXR on intestinal glucose homeostasis remain elusive.
Long Zhao, Zefeng Xuan, Wenfeng Song, Shiyu Zhang, Zequn Li, Guangyuan Song, Xingxin Zhu, Haiyang Xie, Shusen Zheng, P. Song   +9 more
semanticscholar   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Fine-tuning of SIRT1 expression is essential to protect the liver from cholestatic liver disease [PDF]

, 2019
Cholestasis comprises aetiologically heterogeneous conditions characterized by accumulation of bile acids in the liver that actively contribute to liver damage.
Banales, Jesus M, Beraza, Naiara, Blokker, Britt A, Echeandia, Marta, Fuchs, Claudia, Galduroz, Mikel, Gutierrez-de Juan, Virginia, Halilbasic, Emina, Le Gall, Gwenaelle, Maijo, Monica, Martínez-Chantar, María Luz, Mato, José M, Milkiewicz, Malgorzata, Milkiewicz, Piotr, Müller, Michael, Patterson, Angela M, Philo, Mark, Rushbrook, Simon M, Schungel, Rebecca, Ten, Anna, Trauner, Michael, Varela-Rey, Marta   +21 more
core   +4 more sources

Activated farnesoid X receptor attenuates apoptosis and liver injury in autoimmune hepatitis

Molecular Medicine Reports, 2015
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease associated with interface hepatitis, the presence of autoantibodies, regulatory T-cell dysfunction and raised plasma liver enzyme levels.
F. Lian, Yu Wang, Youjun Xiao, Xiwen Wu, Hanshi Xu, L. Liang, Xiu-yan Yang   +6 more
semanticscholar   +1 more source

Molecular network-based analysis of the mechanism of liver injury induced by volatile oils from Artemisiae argyi folium

BMC Complementary and Alternative Medicine, 2017
Background Volatile oils from Artemisiae argyi folium (VOAAF) is reported with hepatotoxicity, but the underlying mechanism is still unclear. Methods In the present study this molecular mechanism was explored with the Ingenuity Pathway Analysis (IPA ...
Hongjie Liu, Sha Zhan, Yan Zhang, Yan Ma, Liang Chen, Lingxiu Chen, Hanqiu Dong, Min Ma, Zhe Zhang   +8 more
doaj   +1 more source

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. [PDF]

, 2017
Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause ...
Feng, Xiaoyi, Gao, Yue, Han, Jiayin, La Frano, Michael R, Li, Chunying, Li, Guiqin, Li, Xiaolong, Liang, Aihua, Liu, Jing, Newman, John W, Pan, Chen, Tian, Jingzhuo, Wang, Lianmei, Xiang, Shixie, Yi, Yan, Zhang, Yushi, Zhao, Yong, Zhu, Jingjing   +17 more
core   +2 more sources

Roles of Bile Acid-Activated Receptors in Monocytes-Macrophages and Dendritic Cells

Cells
Bile acids (BAs), essential for lipid metabolism and fat-soluble vitamin absorption, also act as signaling molecules that regulate immune homeostasis.
Huilin Jia, Xingli He, Tengfei Jiang, Fanzhi Kong   +3 more
doaj   +1 more source

Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease

Liver Research, 2021
Bile acids are a family of atypical steroids generated at the interface of liver-intestinal microbiota acting on a ubiquitously expressed family of membrane and nuclear receptors known as bile acid activated receptors.
Michele Biagioli, Stefano Fiorucci
doaj   +1 more source

The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases

Journal of Lipid Research, 2016
Based on research carried out over the last decade, it has become increasingly evident that bile acids act not only as detergents, but also as important signaling molecules that exert various biological effects via activation of specific nuclear ...
Masayuki Nagahashi, Kizuki Yuza, Yuki Hirose, Masato Nakajima, Rajesh Ramanathan, Nitai C. Hait, Phillip B. Hylemon, Huiping Zhou, Kazuaki Takabe, Toshifumi Wakai   +9 more
doaj   +1 more source