Results 1 to 10 of about 355,625 (339)

Regulation of Id2 gene expression by the type 1 IGF receptor and the insulin receptor substrate-1. [PDF]

Endocrinology, 2001
The Id family of helix-loop-helix proteins is known to be involved in the proliferation and differentiation of several types of cells. The type 1 IGF receptor (IGF-IR) induces either proliferation or differentiation in 32D cells, a murine hemopoietic cell line, depending on the availability of the appropriate substrates for the receptor.
M. Navarro, B. Valentinis, B. Belletti, G. Romano, K. Reiss, R. Baserga   +5 more
semanticscholar   +4 more sources

Research Note: Expression of IGF-1 and IGF-1 receptor proteins in skeletal muscle fiber types in chickens with hepatic fibrosis

Poultry Science, 2022
: We investigated the expression of insulin-like growth factor 1 (IGF-1) and IGF-1 type 1 receptor (IGF-1R) in skeletal muscle fiber types in chickens with hepatic fibrosis induced by bile duct ligation (BDL).
J. Nagasao, H. Fukasawa, K. Yoshioka, N. Fujimura, M. Kobayashi, Y. Tsunemi, A. Nomoto, S. Mitsui, H. Murata, I. Yokoyama, Y. Komiya, K. Arihara   +11 more
doaj   +3 more sources

How ligand binds to the type 1 insulin-like growth factor receptor

Nature Communications, 2018
The human type 1 insulin-like growth factor receptor (IGF-1R) is important for normal human growth and development. Here, the authors present the crystal structures of the IGF-1R ectodomain both in its apo form and in complex with its ligand insulin-like
Yibin Xu, Geoffrey K.-W. Kong, John G. Menting, Mai B. Margetts, Carlie A. Delaine, Lauren M. Jenkin, Vladislav V. Kiselyov, Pierre De Meyts, Briony E. Forbes, Michael C. Lawrence   +9 more
doaj   +2 more sources

Expression of mRNA encoding IGF-I, IGF-II and type 1 IGF receptor in bovine ovarian follicles. [PDF]

Journal of Endocrinology, 2000
IGFs regulate gonadotrophin-stimulated proliferation and differentiation of granulosa and theca cells in vitro. However, the detailed pattern of mRNA expression of IGFs in bovine follicles remains controversial. The objectives of this study were therefore to describe the temporal and spatial pattern of expression of mRNA encoding IGF-I, IGF-II and the ...
D. Armstrong, C. Gutierrez, G. Baxter, A. Glazyrin, G. Mann, KJ Woad, CO Hogg, R. Webb   +7 more
semanticscholar   +3 more sources

Insulin-Like Growth Factor (IGF) Signaling through Type 1 IGF Receptor Plays an Important Role in Remyelination [PDF]

The Journal of Neuroscience, 2003
We examined the role of IGF signaling in the remyelination process by disrupting the gene encoding the type 1 IGF receptor (IGF1R) specifically in the mouse brain by Cre-mediated recombination and then exposing these mutants and normal siblings to cuprizone.
J. Mason, S. Xuan, I. Dragatsis, A. Efstratiadis, J. Goldman   +4 more
semanticscholar   +4 more sources

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Cell, 1993
Newborn mice homozygous for a targeted disruption of insulin-like growth factor gene (Igf-1) exhibit a growth deficiency similar in severity to that previously observed in viable Igf-2 null mutants (60% of normal birthweight). Depending on genetic background, some of the Igf-1(-/-) dwarfs die shortly after birth, while others survive and reach ...
Jeh-Ping Liu, J. Baker, Archlbald S. Perkins, E. Robertson, A. Efstratiadis   +4 more
semanticscholar   +4 more sources

IGF type 1 receptor ligand binding characteristics are altered in a subgroup of children with intrauterine growth retardation. [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2001
The IGFs, IGF-I and IGF-II, regulate fetal growth by activating IGF type 1 receptors (IGF-IR). We aimed to quantify the binding of IGF-I to its cognate receptors in intrauterine growth-retarded children (IUGR). We measured the affinity of the erythrocyte IGF-IR and the number of IGF-IR receptors in 17 children with retarded growth (mean height, -2.7 SD)
B. Ducos, S. Cabrol, M. Houang, L. Périn, M. Holzenberger, Y. Bouc   +5 more
semanticscholar   +4 more sources

IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, phosphatidylinositol-3 kinase pathway and plasmin system. [PDF]

Journal of Endocrinology, 2000
SH-SY5Y human neuroblastoma cells express IGF receptors, IGFs and IGF binding proteins (IGFBPs), and provide a model for studying the role of the IGF system in human neuronal development. We investigated the effect of IGF-I and des(1-3)IGF-I on the motility of SH-SY5Y cells by a cell migration assay based on the assessment of the number of cells which ...
A. Puglianiello, D. Germani, P. Rossi, S. Cianfarani   +3 more
semanticscholar   +4 more sources

Insulin-like growth factor (IGF) binding protein-3 interacts with the type 1 IGF receptor, reducing the affinity of the receptor for its ligand: an alternative mechanism in the regulation of IGF action. [PDF]

Endocrinology, 1997
With a view to determining the mechanisms by which insulin-like growth factor binding protein-3 (IGFBP-3) and its proteolytic fragments modulate IGF action, we used a fibroblast cell line to investigate the possibility of an interaction with the type 1 IGF receptor (IGFR-1).
S. Mohseni-Zadeh, M. Binoux
semanticscholar   +4 more sources

Des(1–3)IGF-1 Treatment Normalizes Type 1 IGF Receptor and Phospho-Akt (Thr 308) Immunoreactivity in Predegenerative Retina of Diabetic Rats [PDF]

Journal of Diabetes Research, 2003
Little is known about interventions that may prevent predegenerative changes in the diabetic retina. This study tested the hypothesis that immediate, systemic treatment with an insulin-like growth factor (IGF)-1 analog can prevent abnormal accumulations ...
A. Kummer, B. Pulford, D. Ishii, G. Seigel   +3 more
semanticscholar   +3 more sources