Insulin-Like Growth Factor (IGF) Signaling through Type 1 IGF Receptor Plays an Important Role in Remyelination [PDF]
The Journal of Neuroscience, 2003 We examined the role of IGF signaling in the remyelination process by disrupting the gene encoding the type 1 IGF receptor (IGF1R) specifically in the mouse brain by Cre-mediated recombination and then exposing these mutants and normal siblings to cuprizone.
Jeffrey L, Mason +4 more
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Membrane-associated insulin-like growth factor (IGF) binding structures in placental cells [PDF]
Journal of the Serbian Chemical Society, 2003 The biological activities of IGF-I and –II are mediated mainly by the type 1 IGF receptor (IGF 1R) and controlled by their interaction with soluble proteins, the IGF binding proteins (IGFBPs). Although there is a growing body of evidence that some IGFBPs
Masnikosa Romana M. +2 more
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Zinc partitions IGFs from soluble IGF binding proteins (IGFBP)-5, but not soluble IGFBP-4, to myoblast IGF type 1 receptors [PDF]
Journal of Endocrinology, 2004 Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands. However, there is a need for data concerning
R H, McCusker, J, Novakofski
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The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease
Frontiers in Endocrinology, 2020 The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracting surface that
Whitney L. Stuard +2 more
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Radioresistant laryngeal cancers upregulate type 1 IGF receptor and exhibit increased cellular dependence on IGF and EGF signalling [PDF]
Clinical Otolaryngology, 2019 AbstractObjectivesPatients failing radiotherapy for laryngeal squamous cell carcinoma (LSCC) often require salvage total laryngectomy which has major functional consequences, highlighting a need for biomarkers of radiotherapy resistance. In other tumour types, radioresistance has been linked to epidermal growth factor receptor (EGFR) and type 1 insulin‐
Ali Qureishi +6 more
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Therapeutic Targeting of the IGF Axis
Cells, 2019 The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to disease.
Eliot Osher, Valentine M. Macaulay
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PACAP type I receptor transactivation is essential for IGF‐1 receptor signalling and antiapoptotic activity in neurons [PDF]
The EMBO Journal, 2007 Insulin-like growth factor-1 (IGF-1) and pituitary adenylyl cyclase activating polypeptide (PACAP) are both potent neurotrophic and antiapoptotic factors, which exert their effects via phosphorylation cascades initiated by tyrosine kinase and G-protein-coupled receptors, respectively. Here, we have adapted a recently described phosphoproteomic approach
Nicolas, Delcourt +6 more
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The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes
Rambam Maimonides Medical Journal, 2011 Patients with type 2 diabetes (T2D) are at increased risk of developing cancer. This evidence arises from numerous epidemiologic studies that relate a positive association between T2D and cancer. In-vitro and several in-vivo experiments have attempted to
Derek LeRoith +2 more
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Intervertebral disc degeneration in mice with type II diabetes induced by leptin receptor deficiency
BMC Musculoskeletal Disorders, 2020 Background The leptin receptor-deficient knockout (db/db) mouse is a well-established model for studying type II diabetes mellitus (T2DM). T2DM is an important risk factor of intervertebral disc degeneration (IVDD). Although the relationship between type
Xinhua Li +14 more
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Des(1–3)IGF‐1 Treatment Normalizes Type 1 IGF Receptor and Phospho‐Akt (Thr 308) Immunoreactivityin Predegenerative Retina of Diabetic Rats [PDF]
Journal of Diabetes Research, 2003 Little is known about interventions that may prevent predegenerative changes in the diabetic retina. This study tested the hypothesis that immediate, systemic treatment with an insulin‐like growth factor (IGF)‐1 analog can prevent abnormal accumulations of type 1 IGF receptor, and phospho‐Akt (Thr 308) immunoreactivity in predegenerative retinas of ...
Kummer, A. +3 more
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