Results 11 to 20 of about 355,625 (339)
IGF-I and insulin activate mitogen-activated protein kinase via the type 1 IGF receptor in mouse embryonic stem cells. [PDF]
Reproduction, 2007 Although IGF-I and insulin are important modulators of preimplantation embryonic physiology, the signalling pathways activated during development remain to be elucidated. As a model of preimplantation embryos, pluripotent mouse embryonic stem cells were used to investigate which receptor mediated actions of physiological concentrations of IGF-I and ...
T. T. Nguyen +3 more
semanticscholar +5 more sources
The EGF receptor interacts with the type 1 IGF receptor and regulates its stability.
Biochemical and Biophysical Research Communications, 2007 Both the epidermal growth factor receptor (EGFR) and type 1 insulin-like growth factor receptor (IGF1R) require homo- and hetero-dimerisation with their own family members to acquire full function. We recently showed that IGF1R gene silencing led to EGFR hyper-phosphorylation in human breast cancer cells, and hypothesised that this crosstalk might be ...
J. Riedemann +3 more
semanticscholar +4 more sources
Journal of Biological Chemistry, 1989 We have produced and characterized the binding properties of three structural analogs of human insulin-like growth factor I (hIGF-I). These analogs are [1-62]hIGF-I, an analog lacking the carboxyl-terminal 8-amino acid D region of hIGF-I; [1-27, Gly4, 38-70]hIGF-I, an analog in which residues 28-37 of the C region of hIGF-I are replaced by a 4-reside ...
M. Bayne +6 more
semanticscholar +4 more sources
Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? [PDF]
PLoS ONE, 2011 Mutations in insulin/IGF-1 signaling pathway have been shown to lead to increased longevity in various invertebrate models. Therefore, the effect of the haplo-insufficiency of the IGF-1 receptor (Igf1r(+/-)) on longevity/aging was evaluated in C57Bl/6 ...
Alex F Bokov +11 more
doaj +1 more source
IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. [PDF]
PLoS ONE, 2010 BACKGROUND:Insulin-like growth factor-I receptor (IGF-IR) is a tyrosine kinase receptor (RTK) associated with caveolae, invaginations of the plasma membrane that regulate vesicular transport, endocytosis and intracellular signaling.
Barbara Salani +7 more
doaj +1 more source
PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons [PDF]
The EMBO Journal, 2007 Insulin-like growth factor-1 (IGF-1) and pituitary adenylyl cyclase activating polypeptide (PACAP) are both potent neurotrophic and antiapoptotic factors, which exert their effects via phosphorylation cascades initiated by tyrosine kinase and G-protein-coupled receptors, respectively. Here, we have adapted a recently described phosphoproteomic approach
Joël Bockaert +6 more
+7 more sources
Role of ubiquitination in IGF-1 receptor signaling and degradation. [PDF]
PLoS ONE, 2007 BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase ...
Bita Sehat +4 more
doaj +1 more source
IGF Type 1 Receptor: A Cell Cycle Progression Factor That Regulates Aging [PDF]
Cell Cycle, 2003 International ...
Dupont, Joëlle, Holzenberger, M.
openaire +4 more sources
Scientific Reports, 2021 Insulin-like Growth Factor-1 (IGF-1) is involved in the normal development and survival of retinal cells. Low-density lipoprotein Receptor-related Protein-1 (LRP1) plays a key role on the regulation of several membrane proteins, such as the IGF-1 ...
Virginia Actis Dato +2 more
doaj +1 more source
Membrane-associated insulin-like growth factor (IGF) binding structures in placental cells [PDF]
Journal of the Serbian Chemical Society, 2003 The biological activities of IGF-I and II are mediated mainly by the type 1 IGF receptor (IGF 1R) and controlled by their interaction with soluble proteins, the IGF binding proteins (IGFBPs). Although there is a growing body of evidence that some IGFBPs
ROMANA MASNIKOSA +2 more
doaj +3 more sources