Results 221 to 230 of about 85,930 (259)

Type 1 IGF receptor in human breast diseases

Breast Cancer Research and Treatment, 1992
The first step of the action of IGF1 and IGF2 (IGFs) is their binding to membrane receptors. IGF binding sites have been characterized by competitive binding and cross-linking techniques in human breast cancer cell lines as well as in human breast cancers and in human benign breast diseases.
J P, Peyrat, J, Bonneterre
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Involvement of phenylalanine 23 in the binding of IGF-1 to the insulin and type I IGF receptor

Regulatory Peptides, 1996
The hydrophobic residue Phe-23 lies on a surface of insulin like growth factor 1 (IGF-1) which may be involved in binding to the type I IGF and insulin receptors. The possibility that Phe-23 participates directly in binding to these receptors has been investigated by comparing the properties of [F23G]IGF-1, a mutant of insulin-like growth factor 1 in ...
D R, Hodgson, F E, May, B R, Westley
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IGF Resistance: The Role of the Type 1 IGF Receptor

2005
The growth hormone (GH)-insulin-like growth factor (IGF)-I axis is the dominant regulator of somatic growth in vertebrates. Growth deficits of varying severity follow experimental deletion of individual IGF axis components, with all but about 15% of the growth of an adult mouse explicable by the combined contributions of growth hormone and IGF-I ...
Steven D. Chernausek, M. Jennifer Abuzzahab, Wieland Kiess, Doreen Osgood, Anke Schneider, Robert J. Smith   +5 more
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P46 Studies on the bivalent interaction of IGF-II with the insulin and type 1 IGF receptors

Growth Hormone & IGF Research, 2010
demonstrated the role of the IGF system in the regulation of trophoblast proliferation and survival and alterations in the IGF ligands or the receptors could have implications in the pathogenesis of trophoblastic diseases. The aim of this study was to investigate the role of the IGF system in trophoblast cell differentiation by evaluating the ...
C.L. Alvino, S.C. Ong, K.A. McNeil, G.W. Booker, J.C. Wallace, B.E. Forbes   +5 more
openaire   +1 more source

Insulin-like growth factor (IGF) suppression of IGFBP-1 production: evidence for mediation by the type I IGF receptor

Regulatory Peptides, 1993
The regulation of insulin-like growth factor binding protein-1 (IGFBP-1) by its ligands, IGF-I and IGF-II, was studied in continuous cultures of HepG2 human hepatoma cells. Both IGF-I and IGF-II in concentrations as low as 1-10 nmol/l caused significant suppression of IGFBP-I protein levels.
P D, Lee, A, Suwanichkul, L A, DePaolis, M B, Snuggs, S L, Morris, D R, Powell   +5 more
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Developmental changes in the expression patterns of IGFs, type 1 IGF receptor and IGF-binding proteins-2 and -4 in perinatal rat lung

Journal of Molecular Endocrinology, 1995
ABSTRACT The insulin-like growth factors (IGF-I and IGF-II), their receptors and binding proteins (IGFBPs) are endogenously expressed in a number of tissues including the lung during fetal and neonatal development. This endogenous autocrine/paracrine IGF 'system', together with endocrine sources, contributes to the regulation of lung cell proliferation.
D C, Batchelor, A M, Hutchins, M, Klempt, S J, Skinner   +3 more
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Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats

Mechanisms of Ageing and Development, 1993
Insulin-like growth factor-1 (IGF-1) is an anabolic hormone that mediates the actions of growth hormone (GH) and is found at lower concentrations in aged animals. These decreases in GH and IGF-1 appear to have important physiological consequences for aging, since protein synthesis decreases with age, and administration of GH and/or IGF-1 has been shown
A P, D'Costa, J E, Lenham, R L, Ingram, W E, Sonntag   +3 more
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Dysregulation of the Type 1 IGF receptor as a paradigm in tumor progression

Molecular and Cellular Endocrinology, 1998
The Type 1 IGF receptor plays a critical role in cell progression. During normal ontogeny it is expressed by every proliferating cell, where it functions as a potent cell survival agent. Disruption of the Type 1 IGF receptor gene by homologous recombination results in severely growth retarded animals which invariably die at birth.
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Significance of nuclear phospholipase C signaling through type 1 IGF receptor.

Journal of endocrinological investigation, 2004
The existence of a nuclear polyphosphoinositol metabolism independent from that at the plasma membrane is now widely recognized. Specific changes in the nuclear phosphatidylinositol (Ptdlns) metabolism have been implicated in cell growth, differentiation, and neoplastic transformation.
COCCO, LUCIO ILDEBRANDO, S. Capitani, MARALDI, NADIR, MARTELLI, ALBERTO MARIA, MAZZOTTI, GIOVANNI, MANZOLI, FRANCESCO ANTONIO   +5 more
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Gene expression of insulin-like growth factors (IGFs), the type 1 IGF receptor, and IGF-binding proteins in dexamethasone-induced fetal growth retardation.

Endocrinology, 1992
Altered gene expression and/or actions of the insulin-like growth factors (IGFs) have been implicated in the mediation of both pre- and postnatal growth retardation secondary to glucocorticoid excess. To investigate this possibility, we assessed the gene expression of the IGFs, the type I IGF receptor, and IGF-binding proteins (IGFBPs) in 20-day ...
W A, Price, A D, Stiles, B M, Moats-Staats, A J, D'Ercole   +3 more
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