Results 21 to 30 of about 355,625 (339)

Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor [PDF]

Journal of Clinical Investigation, 2002
Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory increase of beta cell mass and impaired glucose-dependent insulin release. beta cell proliferation and secretion are thought to be regulated by signaling through receptor tyrosine kinases.
Xuan, Shouhong, Kitamura, Tadahiro, Nakae, Jun, Politi, Katerina, Kido, Yoshiaki, Fisher, P. E., Morroni, Manrico, Cinti, Saverio, White, M. F., Herrera, Pedro Luis, Accili, Domenico, Efstratiadis, Argiris   +11 more
openaire   +4 more sources

How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor [PDF]

Structure, 2020
Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via IGF-1R, despite the affinity of insulin-like growth factor II for IGF-1R being within an order of magnitude of that of insulin-like
Andrew I. Webb, Andrew I. Webb, Yibin Xu, Hariprasad Venugopal, Mai B. Margetts, Nicholas S. Kirk, Nicholas S. Kirk, Carlie Delaine, Jarrod J. Sandow, Jarrod J. Sandow, Michael C. Lawrence, Michael C. Lawrence, Tristan I. Croll, Briony E. Forbes   +13 more
openaire   +3 more sources

The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease

Frontiers in Endocrinology, 2020
The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracting surface that
Whitney L. Stuard, Rossella Titone, Danielle M. Robertson   +2 more
doaj   +1 more source

Therapeutic Targeting of the IGF Axis

Cells, 2019
The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to disease.
Eliot Osher, Valentine M. Macaulay
doaj   +1 more source

Intervertebral disc degeneration in mice with type II diabetes induced by leptin receptor deficiency

BMC Musculoskeletal Disorders, 2020
Background The leptin receptor-deficient knockout (db/db) mouse is a well-established model for studying type II diabetes mellitus (T2DM). T2DM is an important risk factor of intervertebral disc degeneration (IVDD). Although the relationship between type
Xinhua Li, Xiaoming Liu, Yiru Wang, Fuming Cao, Zhaoxiong Chen, Zhouyang Hu, Bin Yu, Hang Feng, Zhaoyu Ba, Tao Liu, Haoxi Li, Bei Jiang, Yufeng Huang, Lijun Li, Desheng Wu   +14 more
doaj   +1 more source

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

Cellular and Molecular Life Sciences, 2013
The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development and progression of cancer; however, therapeutics targeting it have had disappointing results in the clinic.
L. Girnita, C. Worrall, Shin-ichiro Takahashi, S. Seregard, A. Girnita   +4 more
semanticscholar   +1 more source

Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]

, 1995
Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Engelhardt, Dieter, Fottner, Christian, Simmler, Pia, Weber, Matthias M.   +3 more
core   +1 more source

The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes

Rambam Maimonides Medical Journal, 2011
Patients with type 2 diabetes (T2D) are at increased risk of developing cancer. This evidence arises from numerous epidemiologic studies that relate a positive association between T2D and cancer. In-vitro and several in-vivo experiments have attempted to
Derek LeRoith, Eyal J. Scheinman, Keren Bitton-Worms   +2 more
doaj   +1 more source

Radioresistant laryngeal cancers upregulate type 1 IGF receptor and exhibit increased cellular dependence on IGF and EGF signalling [PDF]

Clinical Otolaryngology, 2019
AbstractObjectivesPatients failing radiotherapy for laryngeal squamous cell carcinoma (LSCC) often require salvage total laryngectomy which has major functional consequences, highlighting a need for biomarkers of radiotherapy resistance. In other tumour types, radioresistance has been linked to epidermal growth factor receptor (EGFR) and type 1 insulin‐
Ali Qureishi, Ketan A. Shah, Valentine M. Macaulay, Valentine M. Macaulay, Stuart Winter, Tamara Aleksic, Henrik Møller, Guillaume Rieunier   +7 more
openaire   +4 more sources

Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice [PDF]

, 2012
We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell insulin sensitivity.
A. Abbas, A. Skromna, Booth, Bredt, Chen, Cubbon, D. J. Beech, De Meyts, Federici, Fulton, Gatenby, GUILLOT, H. Imrie, H. Viswambharan, J. Smith, Jiang, K. M. Channon, Kubota, Li, M. Gage, M. T. Kearney, N. Yuldasheva, Nakagawa, P. J. Grant, P. Sukumar, R. M. Cubbon, Razani, S. B. Wheatcroft, S. Galloway, S. T. Rashid, S. Xuan, Schleicher, Stegmayr, T. S. Futers, V. K. Gatenby, Vicent, Wheatcroft   +36 more
core   +1 more source