Results 41 to 50 of about 355,625 (339)

IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration

Scientific Reports, 2017
During cortical development, neurons undergo polarization, oriented migration and layer-type differentiation. The biological and biochemical mechanisms underlying these processes are not completely understood.
Alvaro F. Nieto Guil, Mariana Oksdath, Linnea A. Weiss, Diego J. Grassi, Lucas J. Sosa, Marta Nieto, Santiago Quiroga   +6 more
doaj   +1 more source

Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR [PDF]

, 2016
Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. Chordomas commonly recur following surgery and radiotherapy, and there is no effective systemic therapy.
Andrew Bassim Hassan, Duncan eWhitwell, Lisa eBrowning, Mark eMiddleton, Martha eWoodward, Nicholas eAthanasou, Olaf eAnsorge, Rachel ePhillips, Sarah ePratap, Shirley eHenderson, Suzanne ePage, Tamara eAleksic, Valentine Moya Macaulay, Valentine Moya Macaulay   +13 more
core   +3 more sources

Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea Stagnalis) [PDF]

, 2014
With the increase of life span, nonpathological age-related memory decline is affecting an increasing number of people. However, there is evidence that age-associated memory impairment only suspends, rather than irreversibly extinguishes, the intrinsic ...
Alexander, Audesirk, Chaudhury, D. Regl di, Delcourt, Du, G. Kemenes, Hattiangady, Hermann, Hernadi, I. Kemenes, J  zsa, Kemenes, Kemenes, Lee, Markowska, Otto, Otto, Patel, Patel, Pavlopoulos, Pirger, Pirger, Pirger, Roberto, S. Naskar, Sacchetti, Shioda, Silhol, Tamas, Telegdy, Vaudry, Watson, Watson, Yang, Yeoman, Z. Laszlo, Z. Pirger, Zhang   +38 more
core   +2 more sources

Zinc partitions IGFs from soluble IGF binding proteins (IGFBP)-5, but not soluble IGFBP-4, to myoblast IGF type 1 receptors [PDF]

Journal of Endocrinology, 2004
Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands. However, there is a need for data concerning
Robert H. McCusker, Jan E Novakofski
openaire   +3 more sources

The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction. [PDF]

, 2016
Enhancing placental insulin-like growth factor (IGF) availability appears to be an attractive strategy for improving outcomes in fetal growth restriction (FGR).
Aplin, JD, Charnock, Jayne, Crocker, IP, Dilworth, MR, Sibley, CP, Westwood, M   +5 more
core   +1 more source

Targeting the Insulin-Like Growth Factor (IGF) System Is Not as Simple as Just Targeting the Type 1 IGF Receptor

American Society of Clinical Oncology Educational Book, 2012
Overview: Increased signaling of the insulin-like growth factor (IGF) system via alterations in expression levels of its components has been demonstrated in various tumor types. Numerous experimental studies have supported the involvement of the IGF system signaling axis in tumor initiation and progression.
Scotlandi, Katia, Belfiore, Antonino
openaire   +4 more sources

Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]

, 2017
Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F, Di Fatta, C, Fuoco, A, Mancuso, E, Mannino, Gc, Sesti, G, Spiga, R   +6 more
core   +1 more source

Angiotensin II receptor blocker attenuates intrarenal renin-angiotensin-system and podocyte injury in rats with myocardial infarction. [PDF]

PLoS ONE, 2013
The mechanisms and mediators underlying common renal impairment after myocardial infarction (MI) are still poorly understood. The present study aimed to test the hypothesis that angiotensin II type 1 receptor blockers (ARBs) provides renoprotective ...
Zhu-zhi Wen, Mu-yan Cai, Zun Mai, Dong-mei Jin, Yang-xin Chen, Hui Huang, Deng-feng Geng, Jing-feng Wang   +7 more
doaj   +1 more source

CLINICAL AND HORMONAL MILIEU OF 9 PATIENTS WITH PRIMARY GROWTH HORMONE INSENSITIVITY SYNDROME AND THEIR RESPONSE TO IGF-I GENERATION TEST [PDF]

Acta Medica Iranica, 2006
Primary growth hormone insensitivity syndrome (GHIS) is a rare entity which can be due to defects in growth hormone (GH) receptor that is called type 1 Laron syndrome (T1LS) or post receptor defects (type 2 Laron syndrome ).
M. Razzaghy-Azar, M. Nourbakhsh F. Hajighasemi   +1 more
doaj   +1 more source

Expression of insulin-like growth factor receptor type 1 correlate with lymphatic metastases in human gastric cancer.

Polish journal of pathology : official journal of the Polish Society of Pathologists, 2014
Most patients with gastric cancer are diagnosed at advanced clinical stages with a high frequency of lymph node metastasis. It is very important to find novel factors for the early diagnostic and prognostic evaluation of gastric cancer. It has been shown
M. Gryko, J. Kiśluk, D. Cepowicz, J. Zińczuk, Z. Kamocki, K. Guzińska-ustyMowiCz, A. Pryczynicz, J. Czyżewska, A. Kemona, B. Kędra   +9 more
semanticscholar   +1 more source