Results 41 to 50 of about 6,476 (207)

Neural stem cells express melatonin receptors and neurotrophic factors: colocalization of the MTreceptor with neuronal and glial markers [PDF]

, 2004
Background In order to optimize the potential benefits of neural stem cell (NSC) transplantation for the treatment of neurodegenerative disorders, it is necessary to understand their biological characteristics.
McMillan Catherine R, Sharma Rohita, Dao Chung V, Rincón Castro Lyda, Armstrong Kristen J, Niles Lennard P, Doering Laurie C, Kirkham David L   +7 more
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MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations [PDF]

Journal of Pineal Research, 2019
AbstractMelatonin (MLT) exerts its physiological effects principally through two high‐affinity membrane receptors MT1 and MT2. Understanding the exact mechanism of MLT action necessitates the use of highly selective agonists/antagonists to stimulate/inhibit a given MLT receptor. The respective distribution of MT1 and MT2 within the CNS and elsewhere is
Klosen, Paul, Lapmanee, Sarawut, Schuster, Carole, Guardiola, Béatrice, Hicks, David, Pevet, Paul, Felder‐schmittbuhl, Marie Paule   +6 more
openaire   +3 more sources

Regulation of pituitary MT1 melatonin receptor expression by gonadotrophin-releasing hormone (GnRH) and early growth response factor-1 (Egr-1): in vivo and in vitro studies. [PDF]

PLoS ONE, 2014
Melatonin receptor expression exhibits profound developmental changes through poorly understood mechanisms. In mammals, a current model suggests that pubertal reactivation of gonadotrophin-releasing hormone (GnRH) secretion down-regulates MT1 melatonin ...
Sung-Eun Bae, Ian K Wright, Cathy Wyse, Nathalie Samson-Desvignes, Pascale Le Blanc, Serge Laroche, David G Hazlerigg, Jonathan D Johnston   +7 more
doaj   +1 more source

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]

, 2008
The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Alison Downing, Ando, Andrew S. I. Loudon, Ashburner, Bae, Barrett, Bartness, Bechtold, Benoit Malpaux, Bockers, Bockers, Bockmann, Brahimi-Horn, Camon, Carr, Chemineau, Chen, Curlewis, Daphne Mouzaki, Dardente, Dave W. Burt, David Waddington, Draghici, Dupre, Fukuhara, Gerald A. Lincoln, Ghorbel, Graham, Grossmann, Hanon, Hazlerigg, Hazlerigg, Hazlerigg, Hogenesch, Hu, Hu, Johnston, Johnston, Johnston, Julian R. E. Davis, Kel, Kijas, Klosen, Ko, Lamolet, Lee, Lincoln, Lincoln, Lincoln, Lincoln, Malpaux, Merks, Messager, Michan, Morgan, Morgan, Mutoh, Nakao, Naya, Naya, Nilaweera, Oki, Poulin, Reick, Revollo, Richard Talbot, Roepke, Rutter, Samal, Sandrine M. Dupré, Schroeder, Segawa, Stehle, Stirland, Storey, Su, Tobler, Tournier, Wagner, Westfall, Williams, Wittkowski, Yang, Yokoyama   +83 more
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Mitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 receptors in mitochondria inhibiting respiration

Cell Chemical Biology, 2023
The presence of signaling-competent G protein-coupled receptors in intracellular compartments is increasingly recognized. Recently, the presence of Gi/o protein-coupled melatonin MT1 receptors in mitochondria has been revealed, in addition to the plasma membrane.
Somalo-Barranco, Gloria, Pagano Zottola, Antonio, Abdulrahman, Abdulrasheed, El Zein, Rami, Cannich, Astrid, Muñoz, Lourdes, Serra, Carme, Oishi, Atsuro, Marsicano, Giovanni, Masri, Bernard, Bellocchio, Luigi, Llebaria, Amadeu, Jockers, Ralf   +12 more
openaire   +3 more sources

Rhythmic Expression of Functional MT1 Melatonin Receptors in the Rat Adrenal Gland [PDF]

Endocrinology, 2007
We previously demonstrated that melatonin is involved in the regulation of adrenal glucocorticoid production in diurnal primates through activation of MT1 membrane-bound melatonin receptors. However, whether melatonin has a similar role in nocturnal rodents remains unclear.
Richter, Hans G., Torres Farfán, Claudia, García Sesnich, Jocelyn, Abarzúa Catalán, Lorena, Henríquez Luna, Mauricio, Alvarez Felmer, Mauro, Gaete, Fernando, Rehren, Germán E., Serón Ferré, María   +8 more
openaire   +4 more sources

Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption

Endocrinology, Diabetes & Metabolism, 2021
Background Melatonin is a hormone secreted by the pineal gland in a circadian rhythmic manner with peak synthesis at night. Melatonin signalling was suggested to play a critical role in metabolism during the circadian disruption.
Cynthia Tchio, Kenkichi Baba, Giuseppe Piccione, Gianluca Tosini   +3 more
doaj   +1 more source

Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptors [PDF]

Brain Research, 2008
Although G protein-coupled MT1 and MT2 melatonin receptors are expressed in neurons of the mammalian brain including in humans, relatively little is known about the influence of native MT1 and MT2 melatonin receptors on neuronal melatonin signaling. Whereas human cerebellar granule cells (CGC) express only MT1 receptors, mouse CGC express both MT1 and ...
IMBESI, MARTA, UZ T, DZITOYEVA S, GIUSTI, PIETRO, MANEV H.   +4 more
openaire   +2 more sources

Characterization of the Mel1c melatoninergic receptor in platypus (Ornithorhynchus anatinus). [PDF]

PLoS ONE, 2018
Melatonin is a neurohormone produced in both animals and plants. It binds at least three G-protein-coupled receptors: MT1 and MT2, and Mel1cGPR. Mammalian GPR50 evolved from the reptilian/avian Mel1c and lost its capacity to bind melatonin in all the ...
Célia Gautier, Sophie-Penelope Guenin, Isabelle Riest-Fery, Tahlia Jade Perry, Céline Legros, Olivier Nosjean, Valerie Simonneaux, Frank Grützner, Jean A Boutin   +8 more
doaj   +1 more source

Is there a role for melatonin in fibromyalgia? [PDF]

, 2019
Fibromyalgia, characterised by persistent pain, fatigue, sleep disturbance and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis.
Acuna-Castroviejo D, Escames G, Reiter RJ, Ambriz-Tututi M, Rocha-González HI, Cruz SL, et al., Bunney WE, Bunney BG, Castaño MY, Garrido M, Delgado-Adamez J, et al., Castaño MY, Garrido M, Rodríguez AB, et al., Caumo W, Hidalgo MP, Souza A, et al., Chen WW, Zhang X, Huang WJ., Citera G, Arias MA, Maldonado-Cocco JA, et al., Clauw DJ, Comai S, Gobbi G, de Zanette SA, Vercelino R, Laste G, et al., Fatima G, Das SK, Mahdi AA, Fayed N, Garcia-Campayo J, Magallón R, et al., Hardeland R, Cardinali DP, Srinivasan V, et al., Herrero JF, Laird JM, López-García JA, Hussain SA, Al-Khalifa II, Jasim NA, et al., Ismail SA, Mowafi HA, Laurido C, Pelissie T, Soto-Moyano R, et al., Lawson K, Macfarlane GJ, Kronisch C, Dean LE, et al., Masruha M, de Souza Vieira DS, Minett TS, et al., Masruha MR, Lin J, de Souza Vieira DS, et al., Musshoff U, Riewenherm D, Berger E, et al., Nava F, Carta G, Noseda R, Hernández A, Valladares L, et al., Pardini M, Cordano C, Benassi F, et al., Pyke TL, Osmotherly PG, Baines S, Queiroz LP, Quera Salva MA, Hartley S, Barbot F, et al., San L, Arranz B, Senel K, Baygutalp F, Baykal T, et al., Sluka KA, Clauw DJ, Srinivasan V, Brzezinski A, Pandi-Perumal SR, et al., Srinivasan V, Lauterbach EC, Ho KY, et al., Srinivasan V, Pandi-Perumal SR, Trahkt I, et al., Sánchez-Domínguez B, Bullón P, Román-Malo L, et al., Torres-Farfan C, Richter HG, Rojas-García P, et al., Vanecek J, Wan Q, Man HY, Liu F, et al., Webb SM, Wikner J, Hirsch U, Wetterberg L, et al., Wilhelmsen M, Amirian I, Reiter RJ, et al., Wolfe F, Clauw DJ, Fitzcharles MA, et al., Wood PB, Schweinhardt P, Jaeger E, et al., Üçeyler N, Zeller D, Kahn AK, et al.   +44 more
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