Results 81 to 90 of about 6,476 (207)

Circadian regulation of reproduction: From gamete to offspring [PDF]

, 2013
P01326625; Grants: GNT0519315Few challenges are more critical to the survival of a species than reproduction. To ensure reproductive success, myriad aspects of physiology and behaviour need to be tightly orchestrated within the animal, as well as timed ...
Boden, M., Kennaway, D., Varcoe, T.
core   +1 more source

Melatonin and the Dental Pulp: A Scoping Review

International Endodontic Journal, Volume 59, Issue 4, Page 590-613, April 2026.
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer, Konrad Kleszczynski, Edgar Schäfer   +2 more
wiley   +1 more source

Comment développer un antidépresseur au mécanisme d’action innovant : l’exemple de l’agomélatine [PDF]

, 2005
Divers axes de recherche ont été suivis pour obtenir de nouveaux traitements de la dépression plus efficaces, mieux tolérés et d’action plus rapide. Parmi ces axes de recherche, la mélatonine, synchronisateur endogène des rythmes biologiques chez les ...
Boyer, Pierre-Alain, de Bodinat, Christian, Delalleau, Bruno, Mocaër, Elisabeth   +3 more
core   +1 more source

Behavioral Phenotype and Neuropsychological Profile of an Adult With Smith‐Magenis Syndrome due to a Previously Unreported RAI1 Mutation: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Smith‐Magenis Syndrome (SMS) is an uncommon genetic disorder caused by microdeletions of chromosome 17p11.2 including the RAI1 gene, or loss‐of‐function mutations that directly affect RAI1. Due to the involvement of RAI1 in neurodevelopment, SMS leads to typical pathologic features in the behavioral and physical phenotype that must be ...
Edgar Andrés Chavarría‐Martínez, Julen Arellano‐Sandúa, Ruth Arias‐Hidalgo, Ana Patiño‐García, Adrián Cano‐Prous   +4 more
wiley   +1 more source

Structure-based discovery of potent and selective melatonin receptor agonists

eLife, 2020
Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer.
Nilkanth Patel, Xi Ping Huang, Jessica M Grandner, Linda C Johansson, Benjamin Stauch, John D McCorvy, Yongfeng Liu, Bryan Roth, Vsevolod Katritch   +8 more
doaj   +1 more source

Melatonin MT1 receptors as a target for the psychopharmacology of bipolar disorder: A translational study

Pharmacological Research, 2023
The treatment of bipolar disorder (BD) still remains a challenge. Melatonin (MLT), acting through its two receptors MT1 and MT2, plays a key role in regulating circadian rhythms which are dysfunctional in BD.
Margherita Tassan Mazzocco, Claudia Pisanu, Luigi Russo, Clementina Acconcia, Marco Cambiaghi, Sofia De Girolamo, Alessio Squassina, Laura Cherchi, Elena Monzani, Francesca Scebba, Debora Angeloni, Danilo De Gregorio, Sofia Nasini, Stefano Dall’Acqua, Stefania Sut, Federico Suprani, Mario Garzilli, Beatrice Guiso, Vittoria Pulcinelli, Maria Novella Iaselli, Ilaria Pinna, Giulia Somaini, Laura Arru, Carolina Corrias, Pasquale Paribello, Federica Pinna, Gabriella Gobbi, Flavia Valtorta, Bernardo Carpiniello, Mirko Manchia, Stefano Comai   +30 more
doaj   +1 more source

The role and therapeutic potential of melatonin in age-related ocular diseases [PDF]

, 2017
The eye is continuously exposed to solar UV radiation and pollutants, making it prone to oxidative attacks. In fact, oxidative damage is a major cause of age-related ocular diseases including cataract, glaucoma, age-related macular degeneration and ...
Colligris, Basilio, Crooke, Almudena, Huete Toral, Fernando, Pintor, Jesús   +3 more
core   +2 more sources

Quercetin and Its Nano‐Based Formulations Against Skin Cancer: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Skin cancer is one of the most prevalent malignancies worldwide, characterized by the abnormal growth of skin cells and significant clinical challenges. Conventional treatments—including surgery, chemotherapy, and radiotherapy—often suffer from limitations such as adverse side effects, tumor resistance, and inadequate efficacy.
Mahtab Khanyabzadeh, Alireza Emamifar, Nikoo Emtiazi, Amir Nazari, Masoumeh Shekarriz, Amin Karami, Fateme Hashem Beik Mahallati, Rahineh Nomani Lafmejani, Atieh Dariush, Seyed Mohammad Mahdi Rohani, Elaheh Mohseni Vadeghani, Negin Khoshnood, Hamid Reza Ojaghi, Fatemeh Rezaei‐Tazangi, Reza Arefnezhad   +14 more
wiley   +1 more source

Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells

Cellular & Molecular Biology Letters, 2019
Melatonin receptors MT1 and MT2 (genes officially named MTNR1A and MTNR1B, respectively) play crucial roles in melatonin-mediated regulation of circadian rhythms, the immune system, and control of reproduction in seasonally breeding animals.
Yuan Gao, Xiaochun Wu, Shuqin Zhao, Yujun Zhang, Hailong Ma, Zhen Yang, Wanghao Yang, Chen Zhao, Li Wang, Quanwei Zhang   +9 more
doaj   +1 more source

Modulation of human ovarian function by melatonin

Frontiers in Bioscience-Elite, 2020
Melatonin, a hormone which is primarily released by the pineal gland, has a wide range of actions in the female reproductive tract. While the melatonin receptor subtype, MT3, has been identified in amphibian animals and birds, in humans and other mammals,
Seema Rai, Hindole Gosh
doaj   +1 more source