Results 31 to 40 of about 18,745 (209)

Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency [PDF]

Cell Metabolism, 2006
Most animal models of obesity and hyperinsulinemia are associated with increased vagal cholinergic activity. The M3 muscarinic acetylcholine receptor subtype is widely expressed in the brain and peripheral tissues and plays a key role in mediating the physiological effects of vagal activation.
Gautam, Dinesh, Gavrilova, Oksana, Jeon, Jongrye, Pack, Stephanie, Jou, William, Cui, Yinghong, Li, Jian H., Wess, Jürgen   +7 more
openaire   +2 more sources

Pharmacological Characterization of Itch-Associated Response Induced by Repeated Application of Oxazolone in Mice

Journal of Pharmacological Sciences, 2010
We investigated pharmacological characteristics of the itch-associated response to chronic dermatitis induced by 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone) repeated application in mice.
Yukihito Tsukumo, Daisuke Harada, Haruhiko Manabe   +2 more
doaj   +1 more source

M3 subtype of muscarinic acetylcholine receptor promotes cardioprotection via the suppression of miR-376b-5p. [PDF]

PLoS ONE, 2012
The M(3) subtype of muscarinic acetylcholine receptors (M(3)-mAChR) plays a protective role in myocardial ischemia and microRNAs (miRNAs) participate in many cardiac pathophysiological processes, including ischemia-induced cardiac injury.
Zhenyu Pan, Yueping Guo, Hanping Qi, Kai Fan, Shu Wang, Hua Zhao, Yuhua Fan, Jing Xie, Feng Guo, Yunlong Hou, Ning Wang, Rong Huo, Yong Zhang, Yan Liu, Zhimin Du   +14 more
doaj   +1 more source

Review article: pathogenesis and clinical manifestations of gastrointestinal involvement in systemic sclerosis. [PDF]

, 2017
BACKGROUND: Gastrointestinal tract (GIT) involvement is a common cause of debilitating symptoms in patients with systemic sclerosis (SSc). There are no disease modifying therapies for this condition and the treatment remains symptomatic, largely owing to
Abraham, Assandri, Assassi, Auluck, Bacher, Baron, Baron, Bodukam, Cavazzana, Chizzolini, Chizzolini, Ciechomska, Clark, Cohen, Colina, Crowell, Denton, Denton, Derk, Derynck, Emmanuel, Frech, Fynne, Gabrielli, Goldblatt, Gregersen, Gu, Hartleb, Heyt, Hinz, Hu, Hudson, Hung, Ingraham, Jimenez, Johnson, Jung, Kaburaki, Kaneko, Khanna, Khanna, Koh, Krause, Kumar, Luciano, Malandrini, Manetti, Manetti, Manetti, Marie, Marie, Marie, Marie, Marie, Matucci-Cerinic, Maurer, Miao, Milette, Murray-Lyon, Nagaraja, O'Reilly, O'Reilly, Omair, Parker, Parodi, Pattanaik, Peng, Piasecki, Poelman, Radic, Raja, Raja, Raja, Rajapakse, Reynolds, Richard, Richardson, Rigamonti, Riviere, Roulis, Russell, Sakkas, Savarino, Savarino, Shawis, Singh, Singh, Sjogren, Skare, Solis-Herruzo, Spiegel, Steen, Stern, Stumpf, Thonhofer, Thoua, Trezza, Trojanowska, Valenzuela, Varga, Veale, Vischio, Watson, Wipff, Wynn, Zheng   +105 more
core   +2 more sources

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. [PDF]

, 2013
Organophosphorus pesticides (OPs) are implicated in human asthma. We previously demonstrated that, at concentrations that do not inhibit acetylcholinesterase activity, the OP parathion causes airway hyperreactivity in guinea pigs as a result of ...
Allison D. Fryer, Becky J. Proskocil, Borish L, Crain EF, Crinnion WJ, David B. Jacoby, Donald A. Bruun, Gallo MA, Grodzki AC, Lu C, Nico van Rooijen, Pamela J. Lein, Rozyk KJ   +12 more
core   +1 more source

Cholinergic Regulation of Orexin/Hypocretin Neurons Through M3Muscarinic Receptor in Mice

Journal of Pharmacological Sciences, 2008
The cholinergic system plays an important role in regulation of arousal and REM sleep. In the present study, we showed that a muscarinic receptor agonist, carbachol (CCh), activates almost 20% of orexin-producing neurons (orexin neurons), which play a ...
Kousaku Ohno, Mari Hondo, Takeshi Sakurai   +2 more
doaj   +1 more source

Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs [PDF]

, 2016
Although rhodopsin-like G protein-coupled receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-state proportion of each form and whether this is regulated by receptor ligands is unknown.
Godin, Antoine G., Marsango, Sara, Milligan, Graeme, Pediani, John D., Ward, Richard J.   +4 more
core   +1 more source

Human gastric mucosa expresses glandular M3 subtype of muscarinic receptors [PDF]

Digestive Diseases and Sciences, 1990
Five subtypes of muscarinic receptors have been distinguished by pharmacological and molecular biological methods. This report characterizes the muscarinic subtype present in human gastric mucosa by radioligand binding studies. The receptor density was 27 +/- 6 fmol/mg protein and the tritiated ligand N-methylscopolamine had an affinity of (KD) 0.39 +/-
Pfeiffer, A., Hanack, C., Kopp, R., Tacke, R., Moser, U., Mutschler, E., Lambrecht, G., Herawi, M.   +7 more
openaire   +3 more sources

Additive interaction of intrathecal ginsenosides and neostigmine in the rat formalin test [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundThe authors evaluated the effect of intrathecal mixture of ginsenosides with neostigmine on formalin-induced nociception and made further clear the role of the spinal muscarinic (M) receptors on the activity of ginsenosides.MethodsA catheter ...
Cheon-Hee Park, Park-Ne Kim, Seong-Heon Lee, Myung Ha Yoon   +3 more
doaj   +1 more source

Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

eLife, 2021
G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins. Different agonists can promote differential receptor-induced signaling responses – termed bias – potentially by eliciting ...
Anja Flöser, Katharina Becker, Evi Kostenis, Gabriele König, Cornelius Krasel, Peter Kolb, Moritz Bünemann   +6 more
doaj   +1 more source