Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs [PDF]
, 2016 Although rhodopsin-like G protein-coupled receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-state proportion of each form and whether this is regulated by receptor ligands is unknown.
Godin, Antoine G. +4 more
core +1 more source
eLife, 2021 G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins. Different agonists can promote differential receptor-induced signaling responses – termed bias – potentially by eliciting ...
Anja Flöser +6 more
doaj +1 more source
The Effect of Oral Antihistamines on the Sweating Response During Heat Stress in Adults. [PDF]
AllergyAllergy, Volume 80, Issue 9, Page 2643-2645, September 2025.
Newhouse D +3 more
europepmc +2 more sources
Clathrin-mediated Endocytosis of m3 Muscarinic Receptors [PDF]
Journal of Biological Chemistry, 2004 Receptors as well as some G protein subunits internalize after agonist stimulation. It is not clear whether Galpha(q) or Gbetagamma undergo such regulated translocation. Recent studies demonstrate that m3 muscarinic receptor activation in SK-N-SH neuroblastoma cells causes recruitment of tubulin to the plasma membrane.
Mark M. Rasenick, Juliana S. Popova
openaire +3 more sources
Evidence for Respiratory Neuromodulator Interdependence after Cholinergic Disruption in the Ventral Respiratory Column [PDF]
, 2015 Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50 mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breathing frequency and serotonin (5-HT), substance P (SP),
Forster, Hubert +6 more
core +2 more sources
Functional effects of KCNQ K+ channels in airway smooth muscle
Frontiers in Physiology, 2013 KCNQ (Kv7) channels underlie a voltage-gated K+ current best known for control of neuronal excitability, and its inhibition by Gq/11-coupled, muscarinic signaling. Studies have indicated expression of KCNQ channels in airway smooth muscle (ASM), a tissue
Alexey I Evseev +7 more
doaj +1 more source
Steady-state energy balance in animal models of obesity and weight loss [PDF]
, 2016 Supported by European Union Seventh Framework Programme (FP7/2007-2013, n°266408 (Full4Health)), the Joint Programme of the Medical Faculty of Norwegian University of Science and Technology (NTNU) and St. Olav’s University Hospital, the Liaison Committee
Barrett, Perry +7 more
core +2 more sources
Characterization of the positive and negative inotropic effects of acetylcholine in the human myocardium [PDF]
, 1995 In the human isolated myocardium, acetylcholine (10−9 to 10−3 M) elicited a biphasic inotropic effect (a decrease in the lower and an increase in the higher concentration range) in atrial and a positive inotropic effect in ventricular trabeculae. However,
Bos, E. (Egbert) +3 more
core +7 more sources
Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression [PDF]
, 2015 The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD.
Argibay, Pablo +3 more
core +1 more source
Distribution of Muscarinic Acethylcholine Receptors and Related Signal [PDF]
Türk Biyokimya Dergisi, 2006 Muscarinic receptors are members of G protein coupled receptor family. Molecularcloning studies indicate five intronless genes that encode five muscarinic receptorglycoproteins.
Hülya Cabadak
doaj