Results 71 to 80 of about 18,745 (209)

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

Role of M3 Muscarinic Acethylcholine Receptor Antibodies as a New Marker in Primary Sjögren Syndrome [PDF]

, 2017
Aims: This paper investigates the presence of M3 muscarinic acetylcholine receptor autoantibody present in the serum of patients with primary Sjögren syndrome (pSS).
Borda, Enri Santiago, Ganzinelli, Sabrina Belen, González Arana, Roberto, Pisoni, Cecilia, Reina, Silvia Lorena   +4 more
core   +1 more source

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization [PDF]

, 2018
Spatial intensity distribution analysis (SpIDA) is a recently developed approach for determining quaternary structure information on fluorophore-labelled proteins of interest in situ. It can be applied to live or fixed cells and native tissue.
Marsango, Sara, Milligan, Graeme, Pediani, John D., Ward, Richard J.   +3 more
core   +1 more source

Gut microbiota and central nervous system's direct bidirectional regulation: The mechanisms of the gut–brain axis in irritable bowel syndrome

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Gut microbiota directly modulates central nervous system activity via vagal, sympathetic and sensory neural circuits. Brainstem nuclei integrate microbial signals to regulate gut motility, secretion and visceral sensitivity. DRG neurons and stress‐responsive pathways link microbial cues to host defence and epithelial homeostasis. Dysregulated gut–brain
Jinxia Zhai, Yingjie Li, Jiameng Liu, Cong Dai   +3 more
wiley   +1 more source

Two-step structural changes in M3 muscarinic receptor activation rely on the coupled Gq protein cycle

Nature Communications, 2023
During Gq protein activation, the separated Gαq-GTP forms a stable complex with the ligand-activated hM3R and PLCβ. Here the authors demonstrate that a single M3 receptor FRET probe can display the real-time conformational dynamics of innate receptor by ...
Yong-Seok Kim, Jun-Hee Yeon, Woori Ko, Byung-Chang Suh   +3 more
doaj   +1 more source

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Clapp, LH, Cui, Y, Giblin, JP, Quinn, KV, Tinker, A   +4 more
core   +1 more source

A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and Mechanisms Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Atractylone exhibits diverse pharmacological effects, including anticancer and neuroprotection. A systematic review was conducted following PRISMA guidelines to analyze Atractylone. This study explores Atractylone's sources, biosynthesis, and therapeutic potential.
Hamza Elhrech, Oumayma Aguerd, Meriem El Fessikh, Zouhair Essahli, Taoufiq Benali, Waleed Al Abdulmonem, Learn‐Han Lee, Imane Chamkhi, Abdelhakim Bouyahya   +8 more
wiley   +1 more source

Expression of muscarinic acetylcholine receptors M3 and M5 in osteoporosis [PDF]

Medical Science Monitor, 2014
Cholinergic signaling via muscarinic acetylcholine receptors (mAChR) is known to influence various physiological functions. In bone, M3 mAChR and M5 mAChR were identified on the membrane of osteoblast-like cells. M3 mAChR seems to be particularly relevant for bone physiology, as signaling via this receptor was reported to increase bone formation and ...
Kauschke, Vivien, Lips, Katrin Susanne, Heiss, Christian, Schnettler, Reinhard   +3 more
openaire   +2 more sources

The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Ameliorative Effect of Solifenacin Succinate (Vesicare ®), a Bladder-Selective Antimuscarinic Agent, on Overactive Bladder Symptoms, Especially Urgency Episodes

Journal of Pharmacological Sciences, 2010
Overactive bladder (OAB) syndrome is a common condition that is most often observed in the elderly. Pharmacological treatment with muscarinic receptor antagonists has been most widely used for OAB. An antimuscarinic agent, solifenacin, showed the highest
Akiyoshi Ohtake, Shuichi Sato, Masao Sasamata, Keiji Miyata   +3 more
doaj   +1 more source