Results 71 to 80 of about 18,237 (210)

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Management of an uncommon complication using botulinum toxin type A following prosthetic laryngoplasty

Equine Veterinary Education, EarlyView.
Summary An uncommon complication following prosthetic laryngoplasty was reported in a 4‐year‐old Andalusian mare. The mare was presented with a previously diagnosed left‐sided recurrent laryngeal neuropathy, after initial evaluation the mare underwent ventriculocordectomy and prosthetic laryngoplasty.
J. L. Sanclemente, D. S. Larriva, C. A. Ragle   +2 more
wiley   +1 more source

Muscarinic receptor oligomerization [PDF]

, 2018
G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins.
Alvarez-Curto, Elisa, Marsango, Sara, Milligan, Graeme, Ward, Richard J.   +3 more
core   +1 more source

Arctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance

Journal of Fish Biology, EarlyView.
Abstract Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to ...
Emily P. Williams, Les N. Harris, Jean‐Sébastien Moore, Ella K. Middleton, Shira A. Berkelhammer, Ben Speers‐Roesch, Matthew J. H. Gilbert   +6 more
wiley   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

Effect of STW 5‐II (Iberogast‐N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO‐2 Study

Neurogastroenterology &Motility, EarlyView.
In a parallel, placebo‐controlled study with direct gas infusion into the stomach, STW 5‐II reduced the perception of abdominal symptoms in patients with dyspepsia complaining of bloating when compared to placebo, with a minor effect on gas transit and evacuation, and no effect on visible abdominal distension.
Ariadna Aguilar, Luis Alcala‐Gonzalez, Claudia Barber, Javier Santos, Beatriz Lobo, Carolina Malagelada, Jordi Serra   +6 more
wiley   +1 more source

Two-step structural changes in M3 muscarinic receptor activation rely on the coupled Gq protein cycle

Nature Communications, 2023
During Gq protein activation, the separated Gαq-GTP forms a stable complex with the ligand-activated hM3R and PLCβ. Here the authors demonstrate that a single M3 receptor FRET probe can display the real-time conformational dynamics of innate receptor by ...
Yong-Seok Kim, Jun-Hee Yeon, Woori Ko, Byung-Chang Suh   +3 more
doaj   +1 more source

Xerostomia as a Rare Adverse Effect of Low‐Dose Oral Minoxidil: A Case Report With Recurrence After Rechallenge

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Low‐dose oral minoxidil (LDOM) is an emerging option for the treatment of female pattern hair loss (FPHL), generally well tolerated at doses under 1 mg/day. We report a rare adverse event of significant xerostomia in a 74‐year‐old woman with Hashimoto's thyroiditis, receiving 0.5 mg/day of minoxidil for FPHL.
Nicolò Rivetti
wiley   +1 more source

The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Ameliorative Effect of Solifenacin Succinate (Vesicare ®), a Bladder-Selective Antimuscarinic Agent, on Overactive Bladder Symptoms, Especially Urgency Episodes

Journal of Pharmacological Sciences, 2010
Overactive bladder (OAB) syndrome is a common condition that is most often observed in the elderly. Pharmacological treatment with muscarinic receptor antagonists has been most widely used for OAB. An antimuscarinic agent, solifenacin, showed the highest
Akiyoshi Ohtake, Shuichi Sato, Masao Sasamata, Keiji Miyata   +3 more
doaj   +1 more source

New promising agents against COPD and asthma among the amides of 1-oxo-3-phenyl-isochroman-6-carboxylic acid

Біофізичний вісник, 2023
Background: Bronchodilators, which are compounds that can relax airway smooth muscle, are perhaps the most important component of combination therapy for chronic obstructive pulmonary disease, one of the most common non-communicable diseases in the world,
Олексій Нипорко, Ольга Цимбалюк, Іван Войтешенко, Сергій Старосила, Микола Протопопов, Володимир Бджола   +5 more
doaj   +1 more source