Results 31 to 40 of about 39,843 (183)

Synthesis and anticancer activity of 1,2,4-Benzothiadiazine-1,1-dioxides

Results in Chemistry, 2023
After heart disease, cancer is one of the most intimidating diseases. Currently in the world, cancer has been established to be one of the utmost daunting illnesses in the world today, amongst several human ailments.
Sumit Chhabra, Kamal Shah
doaj   +1 more source

Muscarinic acetylcholine receptor M5 is involved in spermatogenesis through the modification of cell–cell junctions

Reproduction, 2020
Muscarinic acetylcholine receptor (mAChR) antagonists have been reported to decrease male fertility; however, the roles of mAChRs in spermatogenesis and the underlying mechanisms are not understood yet.
Xiao Han, Cong Zhang, Xiangping Ma, Xiaowei Yan, Bohui Xiong, W. Shen, S. Yin, Hongfu Zhang, Qingyuan Sun, Yong Zhao   +9 more
semanticscholar   +1 more source

Ventral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner 

Journal of Pharmacology and Experimental Therapeutics, 2023
Optimization of effort-related choices is impaired in depressive disorders. Acetylcholine (ACh) and dopamine (DA) are linked to depressive disorders, and modulation of ACh tone in the ventral tegmental area (VTA) affects mood-related behavioral responses
E. Nunes, Nardos Kebede, Joshua L. Haight, Daniel J. Foster, C. Lindsley, P. Conn, N. Addy   +6 more
semanticscholar   +1 more source

Carbachol Induces Ca2+-Dependent Contraction via Muscarinic M2 and M3 Receptors in Rat Intestinal Subepithelial Myofibroblasts

Journal of Pharmacological Sciences, 2009
.: Intestinal myofibroblasts (IMFs) that exist adjacent to the basement membrane of intestines have contractility and contribute to physical barriers of the intestine.
Koichi Iwanaga, Takahisa Murata, Muneyoshi Okada, Masatoshi Hori, Hiroshi Ozaki   +4 more
doaj   +1 more source

Cognitive Impairment, Sleep Disturbance, and Depression in Women with Silicone Breast Implants: Association with Autoantibodies against Autonomic Nervous System Receptors

Biomolecules, 2022
Background: Silicone breast implants (SBIs) has been shown to be associated with an increased risk of autoimmune diseases. In the current study, we aimed to explore the potential association between circulating autoantibodies against the autonomic ...
Milena Tocut, Gilad Halpert, Avishai M. Tsur, Kassem Sharif, Harald Heidecke, Yair Levy, Abdulla Watad, Howard Amital, Yehuda Shoenfeld   +8 more
doaj   +1 more source

Design, Synthesis, and Evaluation of a New Fluorescent Ligand for the M₂ Muscarinic Acetylcholine Receptor. [PDF]

ACS Med Chem Lett
The M2 muscarinic acetylcholine receptor (M2R) is a G protein-coupled receptor involved in regulating cardiovascular functions and mediation of central muscarinic effects, such as movement, temperature control, and antinociceptive responses.
Szabó R, Szepesi Kovács D, Kiss DJ, Yazdi ZN, Tóth AD, Brea J, Loza MI, Meszéna D, Wittner L, Ulbert I, Volk B, Hunyady L, Keserű GM.   +12 more
europepmc   +2 more sources

Discovery of M5 Muscarinic Acetylcholine Receptor Antagonists: 1‐Methyl‐4‐Phenylpiperidine Analogs

The FASEB Journal, 2015
Na‐Ra Lee, Xuan Zhang, Mahesh Darna, Guangrong Zheng, Linda Dwoskin   +4 more
openaire   +2 more sources

Generalized predictive model of estimation of inhibition of muscarinic receptors M1-M5

Biomedical Chemistry: Research and Methods, 2020
A general predictive model for assessing the inhibition constant (K_i) value of human acetylcholine muscarinic receptors M1-M5 by potential ligands has been constructed. We used information on the three-dimensional structure of human M1, M2, M4, and M5 receptors, as well as a model of the M3 receptor constructed according to ...
Mikurova, A.V., Skvortsov, V.S., Grigoryev, V.V.   +2 more
openaire   +3 more sources

AGAP1/AP‐3‐dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release [PDF]

The EMBO Journal, 2010
Of the five mammalian muscarinic acetylcholine (ACh) receptors, M(5) is the only subtype expressed in midbrain dopaminergic neurons, where it functions to potentiate dopamine release. We have identified a direct physical interaction between M(5) and the AP-3 adaptor complex regulator AGAP1.
Jacob, Bendor, José E, Lizardi-Ortiz, Robert I, Westphalen, Markus, Brandstetter, Hugh C, Hemmings, David, Sulzer, Marc, Flajolet, Paul, Greengard   +7 more
openaire   +2 more sources

Calcium Mobilization by Activation of M3/M5 Muscarinic Receptors in the Human Retinoblastoma

Journal of Pharmacological Sciences, 2007
Activation of muscarinic acetylcholine receptors (mAChR) is one of the most important signal transduction pathways in the human body. In this study, we investigated the role of mAChR activation in relation to its subtypes in human retinoblastoma cell ...
Dae-Ran Kim, Sang Hoon Rah, Joon Hyung Sohn, Byung-Il Yeh, Chang Mann Ko, Jeong Sook Park, Min-Jeong Kim, Joong Woo Lee, In Deok Kong   +8 more
doaj   +1 more source