Results 61 to 70 of about 39,843 (183)
Journal of Pharmacology and Experimental Therapeutics, 2021 Muscarinic M3 (M3) receptors mediate a wide range of acetylcholine (ACh)-induced functions, including visceral smooth-muscle contraction and glandular secretion.
Risa Okimoto +13 more
semanticscholar +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
, 2017 Mesolimbic dopamine neurons in the ventral tegmental area (VTA) play important roles in mediating the rewarding effects of opiates in addicted rats and in drug relapse.
Haoran G. Wang
semanticscholar +1 more source
Cancer Reports, Volume 8, Issue 11, November 2025.ABSTRACT Background The prevalence of cancer poses significant challenges to treatment, largely because of drug resistance along with other side effects. Current studies have been investigating the growth factors more than other biologic tumor features, such as neurobiologic features.
Mohammad Hossein Azadi +3 more
wiley +1 more source
Pyrrolo-pyridazine Derivatives as Muscarinic M1 Receptor Positive Allosteric Modulators.
ACS Medicinal Chemistry Letters, 2021 Important Compound Classes. Title. Pyrrolo-pyridazine Derivatives as Muscarinic M1 Receptor Positive Allosteric Modulators Patent Application Number. WO 2020/079606A1 Publication Date. April 23, 2020 Priority Application.
B. Blass
semanticscholar +1 more source
British Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran +9 more
wiley +1 more source
GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger
British Journal of Pharmacology, Volume 182, Issue 17, Page 3975-3989, September 2025.G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng +3 more
wiley +1 more source
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Ligand bias at the muscarinic acetylcholine receptor family: opportunities and challenges.
NeuropharmacologyMuscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors (GPCRs) that are activated by the endogenous neurotransmitter, acetylcholine (ACh).
Michaela G. Kaoullas +3 more
semanticscholar +1 more source