Results 131 to 140 of about 10,701 (149)

Multiomic profiling reveals pericyte and smooth muscle cell contributions to CADASIL pathology in cell-specific Notch3 mutant mice

Huang Y, Clementel V, Zhang M, Martinez K, Martinez K, Spillard G, Torres-Sepulveda C, Kisler K, Coba MP, Rust R.   +9 more
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Receptor stoichiometry predicts artery-typical vulnerability to altered Notch signaling during smooth muscle differentiation

Sanlidag S, Virtanen N, Hoursan H, Ristori T, Sjöqvist M, Loerakker S, Sahlgren C.   +6 more
europepmc   +1 more source

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Functional Diversity among Notch1, Notch2, and Notch3 Receptors

Biochemical and Biophysical Research Communications, 2002
To clarify functional diversities among the Notch receptors, we generated truncated forms of Notch1, Notch2, and Notch3 comprising the intracellular domain (aN1, aN2, and aN3) and investigated their transcriptional activities for HES1 and HES5 promoters driving the luciferase reporter gene (HES1-Luc and HES5-Luc).
Kiyoshi, Shimizu, Shigeru, Chiba, Toshiki, Saito, Keiki, Kumano, Yoshio, Hamada, Hisamaru, Hirai   +5 more
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Overexpression of the Notch3 receptor in non-functioning pituitary tumours

Journal of Clinical Neuroscience, 2012
Human non-functioning pituitary adenomas cause hypopituitarism or the compression of adjacent structures. At present, there is no available medical treatment for these tumours. The Notch3 pathway has an important role in the progression of non-functioning pituitary adenomas.
Zengli, Miao, Yifeng, Miao, Yuchang, Lin, Xiaojie, Lu   +3 more
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Abstract 213: Novel NOTCH3 activating mutations identified in tumors sensitive to OMP-59R5, a monoclonal antibody targeting the Notch2 and Notch3 receptors.

Cancer Research, 2013
Abstract The Notch signaling pathway, driven by four Notch family receptors (NOTCH1-4) and five canonical Notch ligands (DLL1, DLL3, DLL4, JAG1, and JAG2) in humans, critically regulates key functions during embryonic development as well as stem cell maintenance and differentiation in adult tissues.
Breanna Wallace, Min Wang, Chris Muriel, Jennifer Cain, Belinda Cancilla, Jalpa Shah, Jie Wei, Austin Gurney, John Lewicki, Aaron Sato, Tim Hoey, Tracy Tang, Ann M. Kapoun   +12 more
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CADASIL-causing mutations do not alter Notch3 receptor processing and activation

NeuroReport, 2006
CADASIL is associated with mutations in the Notch3 gene but the causal mechanisms of the disorder remain unclear. We studied effects of widely established mutations on Notch3 receptor processing and ligand-mediated activation in stable lines of HEK293 and SH-SY5Y cells expressing either human wild-type or mutant Notch3 receptor.
Low W-C, Santa Y, Takahashi K, Tabira T, Kalaria RN   +4 more
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CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk

Experimental Cell Research, 2004
Mutations in the NOTCH3 gene are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary angiopathy leading to strokes and dementia. Pathogenic mutations remove or insert cysteine residues within epidermal growth factor (EGF) repeats in the extracellular domain of the Notch3 ...
Nils, Peters, Christian, Opherk, Simone, Zacherle, Anja, Capell, Petra, Gempel, Martin, Dichgans   +5 more
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Physical Interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 Receptors

Biochemical and Biophysical Research Communications, 2000
The Delta/Serrate/LAG-2 (DSL) domain-containing proteins, Delta1, Jagged1, and Jagged2, are considered to be ligands for Notch receptors. However, the physical interaction between the three DSL proteins and respective Notch receptors remained largely unknown.
K, Shimizu, S, Chiba, T, Saito, K, Kumano, H, Hirai   +4 more
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The Notch3 Receptor and Its Intracellular Signaling-Dependent Oncogenic Mechanisms

2018
During evolution, gene duplication of the Notch receptor suggests a progressive functional diversification. The Notch3 receptor displays a number of structural differences with respect to Notch1 and Notch2, most of which have been reported in the transmembrane and in the intracellular regions, mainly localized in the negative regulatory region (NRR ...
Diana Bellavia, Saula Checquolo, Rocco Palermo, Isabella Screpanti   +3 more
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Abstract 1697: Therapeutic targeting the NOTCH3 receptor with antibody drug conjugates

Cancer Research, 2015
Abstract Activation and mutation of the NOTCH signaling pathway is oncogenic in many tissue types and the target of multiple anti-cancer therapies currently in clinical development. Initial therapeutic strategies designed to target the NOTCH pathway have focused on inhibition of aberrant signaling, but can have undesirable side-effects ...
Kenneth G. Geles, Yijie Gao, Latha Sridharan, Andreas Giannakou, Ting-Ting Yamin, Jonathan Golas, Judy Lucas, Manoj Charati, Xiantang Li, Magali Guffroy, Tim Nichols, Kai Wang, Max Follettie, Andreas Maderna, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra   +16 more
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