Results 171 to 180 of about 2,320,796 (216)

Proteasome inhibition induces neurite outgrowth through posttranslational modification of TrkA receptor

The International Journal of Biochemistry & Cell Biology, 2009
The ubiquitin-proteasome pathway regulates many biological processes, including protein degradation, receptor endocytosis, protein sorting, subnuclear trafficking and neuronal differentiation. While proteasome inhibition is known to induce neurite outgrowth, the signaling mechanisms that mediate these effects have not been defined.
Eun Joo, Song, Hye-Min, Hong, Young Sook, Yoo   +2 more
openaire   +2 more sources

A Designed Peptidomimetic Agonistic Ligand of TrkA Nerve Growth Factor Receptors

Molecular Pharmacology, 2000
A proteolytically stable small molecule beta-turn peptidomimetic, termed D3, was identified as an agonist of the TrkA neurotrophin receptor. D3 binds the Ig-like C2 region of the extracellular domain of TrkA, competes the binding of another TrkA agonist, affords selective trophic protection to TrkA-expressing cell lines and neuronal primary cultures ...
S, Maliartchouk, Y, Feng, L, Ivanisevic, T, Debeir, A C, Cuello, K, Burgess, H U, Saragovi   +6 more
openaire   +2 more sources

TrkA neurogenic receptor regulates differentiation of neuroblastoma cells.

Oncogene, 1995
We examined events associated with neuronal differentiation of neuroblastoma cell line SH-SY5Y. Treatment with nerve growth factor (NGF) and aphidicolin, an inhibitor of DNA polymerases alpha and delta, induces terminal differentiation of SH-SY5Y cells.
W, Poluha, D K, Poluha, A H, Ross
openaire   +1 more source

Estrogen alters trkA and p75 neurotrophin receptor expression within sympathetic neurons

Journal of Neurobiology, 2005
Survival and growth of sympathetic neurons is regulated by nerve growth factor acting through trkA and p75NTR receptors. Sympathetic neurons are also affected by gonadal steroid hormones, particularly estrogen. To determine if estrogen may influence sympathetic neurons via altered neurotrophin receptor expression, we investigated effects of acute or ...
Wohaib, Hasan, H Jesse, Smith, Alison Y, Ting, Peter G, Smith   +3 more
openaire   +2 more sources

EXPRESSION OF TRKA RECEPTOR IN ADULT ZEBRAFISH BRAIN

2019
In our previous study, the presence and distribution of nerve growth factor (NGF) were described in adult zebrafish brain [1]. In mammals, the signaling of mature NGF (mNGF) is transduced by the tropomyosin receptor kinase A (TrkA) and acts as mediator in many essential functions in the central nervous system.
Adriana Petrovici, Adele Leggieri, Luciana Castaldo, Lucianna Maruccio, Carmen Solcan, Carla Lucini   +5 more
openaire   +1 more source

Activation of TRKA receptors

Reactome - a curated knowledgebase of biological pathways, 2007
S Nasi, D Annibali
openaire   +1 more source

The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone‐induced death, through the NGF receptor TrkA

Glia, 2017
Giulia Bonetto, I. Charalampopoulos, A. Gravanis, D. Karagogeos   +3 more
semanticscholar   +1 more source

Ubiquitination of TrkA by Nedd4-2 regulates receptor lysosomal targeting and mediates receptor signaling.

Journal of neurochemistry, 2011
The work was supported by the Instituto de Salud Carlos III – Ministerio de Sanidad y Consumo (FIS) (PI04/2537 and PS09/ 00140) to ML, the Ministry of Science and Innovation of Spain (SAF2005-02197 and SAF2008-02271) to DS and SAF2007-60287, Programa de Suport a Grups de Recerca from the Government of Catalonia (SGR2005-00628) and Ciberned (CB06/05 ...
Georgieva, Maya V., Pablo Llavall, Yolanda de, Sanchis, Daniel, Comella i Carnicé, Joan Xavier, Llovera i Tomàs, Marta   +4 more
openaire   +2 more sources

The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor TrkA

Journal of Biological Chemistry, 1999
S. Meakin, J. MacDonald, E. Gryz, C. Kubu, J. Verdi   +4 more
semanticscholar   +1 more source

Tyrosine kinase A receptor (trkA): a potential marker in epithelial ovarian cancer.

Gynecologic Oncology, 2011
Verónica Tapia, F. Gabler, M. Muñoz, R. Yazigi, A. Paredes, A. Selman, M. Vega, C. Romero   +7 more
semanticscholar   +1 more source