Results 11 to 20 of about 63,264 (143)

Immunomodulatory effects of curcumin on receptor activator of nuclear factor-kappa B ligand in periodontitis

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
Periodontitis is a chronic inflammatory disease of the tooth-supporting structures, often causing alveolar bone loss due to increased osteoclast activity mediated by receptor activator of nuclear factor-kappa B ligand.
Fiki Muhammad Ridho
doaj   +2 more sources

Expression Profiling of Receptor-Activator of Nuclear Factor-Kappa B Ligand in Soft Tissue Tumors

Tohoku Journal of Experimental Medicine, 2019
Bone and soft tissue tumors are derived from mesenchymal cells, and they are hard to treat. Receptor-activator of nuclear factor-kappa B ligand (RANKL) is an essential cytokine for osteoclast differentiation and activation and is expressed on the surface of osteoblasts or stromal cells. In this study, to explore the potential of denosumab treatment for
Riuko Ohashi, Tetsuro Yamagishi, Taro Sasaki   +2 more
exaly   +4 more sources

Peroxiredoxin 1-Toll-like receptor 4-p65 axis inhibits receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation [PDF]

iScience
Summary: Peroxiredoxin 1 (PRDX1), an intracellular antioxidant enzyme, has emerged as a regulator of inflammatory responses via Toll-like receptor 4 (TLR4) signaling.
Jisu Park, Sanggil Kim, Hye-Yeon Jung, Eun Hwan Bae, Minhye Shin, Jae-Il Park, So-Young Choi, Sun-Ju Yi, Kyunghwan Kim   +8 more
doaj   +2 more sources

Receptor activator of nuclear factor kappa-B gene polymorphisms in Iranian periodontitis and peri-implantitis patients. [PDF]

J Periodontal Implant Sci, 2014
Peri-implantitis and periodontitis are inflammatory and infectious diseases of implant and tooth-supporting tissues. Recently, the role of gene polymorphisms of immune response components in the relevant pathogenesis has been investigated. The present study was the first to evaluate the relationship between two known single nucleotide polymorphisms ...
Kadkhodazadeh M, Baghani Z, Ebadian AR, Kaghazchi Z, Amid R.   +4 more
europepmc   +4 more sources

Angiotensin II Induces Aortic Rupture and Dissection in Osteoprotegerin‐Deficient Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background The biological mechanism of action for osteoprotegerin, a soluble decoy receptor for the receptor activator of nuclear factor‐kappa B ligand in the vascular structure, has not been elucidated.
Toshihiro Tsuruda, Atsushi Yamashita, Misa Otsu, Masanori Koide, Yuko Nakamichi, Yoko Sekita‐Hatakeyama, Kinta Hatakeyama, Taro Funamoto, Etsuo Chosa, Yujiro Asada, Nobuyuki Udagawa, Johji Kato, Kazuo Kitamura   +12 more
doaj   +1 more source

Exploring new pathways in endocrine-resistant breast cancer

Exploration of Targeted Anti-tumor Therapy, 2022
The most common breast cancer (BC) subtypes are hormone-dependent, being either estrogen receptor-positive (ER+), progesterone receptor-positive (PR+), or both, and altogether comprise the luminal subtype.
Inês Soares de Pinho, Catarina Abreu, Inês Gomes, Sandra Casimiro, Teresa Raquel Pacheco, Rita Teixeira de Sousa, Luís Costa   +6 more
doaj   +1 more source

Effect of lipopolysaccharide derived from surabaya isolates of Actinobacillus actinomycetemcomitans on alveolar bone destruction [PDF]

Veterinary World, 2018
Background: Actinobacillus actinomycetemcomitans' lipopolysaccharide (LPS) has a high virulence factor. It interacts with serum protein through receptors on the epithelial cell surface, thereby increasing both interleukin (IL)-1β, and IL-6 which results ...
Rini Devijanti Ridwan, Sidarningsih, Tuti Kusumaningsih, Sherman Salim   +3 more
doaj   +1 more source

Receptor Activator of Nuclear Factor-κB Ligand Activates Nuclear Factor-κB in Osteoclast Precursors* [PDF]

Endocrinology, 2001
Receptor activator of nuclear factor-kappa B ligand [RANK ligand (RANK-L)] stimulates mature osteoclasts to resorb bone, a process associated with NF-kappa B activation. RANK-L also prompts macrophages to develop the osteoclast phenotype. Although NF-kappa B is essential for osteoclast differentiation, it is not known whether RANK-L activates this ...
S, Wei, S L, Teitelbaum, M W, Wang, F P, Ross   +3 more
openaire   +2 more sources

Osteoprotegerin and Soluble Receptor Activator of Nuclear Factor-Kappa B Ligand in Exudative Age-Related Macular Degeneration

Acta Medica Iranica, 2014
Calcification and inflammation are among the important cases of exudative age-related macular degeneration (E-ARMD). The aim of the present study was to elucidate if there is any relationship between serum Osteoprotegerin (OPG), soluble receptor ...
Amir Ghorbanihaghjo, Alireza Javadzadeh, Nadereh Rashtchizadeh, Rana Sorkhabi, Hasan Khalili, Babak Rahimi-Ardabili   +5 more
doaj   +2 more sources

Dramatic response of aneurysmal bone cyst to denosumab: Case report and literature review

Clinical Case Reports, 2021
Denosumab, a monoclonal antibody that specifically targets cytokine receptor activator of nuclear factor‐kappa B ligand (RANKL), is a potentially viable option in resistant aneurysmal bone cysts.
Pedram Fadavi, Amir Mohammad Arefpour, Ramyar Hariri, Maryam Vasheghani, Maryam Garousi, Farzad Taghizadeh‐Hesary   +5 more
doaj   +1 more source