Results 31 to 40 of about 63,264 (143)

OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D

Italian Journal of Pediatrics, 2019
Background Type 1 diabetes (T1D) has been associated with a higher fracture risk due to alterations in bone structure and metabolism. On the other hand, the important role of the RANKL/OPG/RANK signaling axis in bone physiology is well established.
Paraskevi Karalazou, Dimitrios Ntelios, Fani Chatzopoulou, Aikaterini Fragou, Maria Taousani, Konstantina Mouzaki, Assimina Galli-Tsinopoulou, Sofia Kouidou, Georgios Tzimagiorgis   +8 more
doaj   +1 more source

The Time Course Changes in Bone Metabolic Markers after Administering the Anti-Receptor Activator of Nuclear Factor-Kappa B Ligand Antibody and Drug Compliance among Patients with Osteoporosis [PDF]

Asian Spine Journal, 2015
Study DesignRetrospective study.PurposeWe conducted a study to investigate the time course changes in bone metabolic markers after the administration of the anti-receptor activator of nuclear factor-kappa B ligand (RANKL) antibody and to assess drug ...
Kazuhide Inage, Sumihisa Orita, Kazuyo Yamauchi, Yoshihiro Sakuma, Go Kubota, Yasuhiro Oikawa, Takeshi Sainoh, Jun Sato, Kazuki Fujimoto, Yasuhiro Shiga, Kazuhisa Takahashi, Seiji Ohtori   +11 more
doaj   +1 more source

Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms

Journal of Pharmacopuncture, 2019
DNA: Deoxyribonucleic acid, BRCA1: Breast cancer gene 1, BRCA2: Breast cancer gene 2,WHO: World Health Organization, Nrf2: Nuclear factor erythroid 2 [NF-E2]-related factor 2 , NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, MDR ...
Mahavir H. Ghante, Prasad G. Jamkhande
doaj   +1 more source

Alterations in bone fracture healing associated with TNFRSF signaling pathways

Frontiers in Pharmacology, 2022
Bone fracture healing is a complex process involving various signaling pathways. It remains an unsolved issue the fast and optimal management of complex or multiple fractures in the field of orthopedics and rehabilitation.
Yanzhao Dong, Haiying Zhou, Ahmad Alhaskawi, Zewei Wang, Jingtian Lai, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Hasan Abdulla, Zhenyu Sun, Hui Lu, Hui Lu   +10 more
doaj   +1 more source

A Comparative Study of Clinicopathological and Immunohistochemical Expression of CD1a, RANK and RANKL in Langerhans Cell Histiocytosis of Jaw and Skull Lesions

Journal of Baghdad College of Dentistry, 2016
Background: Langerhans' cell histiocytosis (LCH) is a group of conditions affecting the reticuloendothelial system. It includes Letterer-Siwe disease, Hand-Schuller-Christian disease and eosinophilic granuloma and most often presents in childhood ...
Alyaa K Mohammed, Bashar H Abdullah
doaj   +1 more source

The regulation of bone turnover in ameloblastoma using an organotypic in vitro co-culture model

Journal of Tissue Engineering, 2016
Ameloblastoma is a rare, odontogenic neoplasm with benign histopathology, but extensive, local infiltrative capacity through the bone tissue it originates in. While the mechanisms of ameloblastoma invasion through the bone and bone absorption are largely
Tuula M Eriksson, Richard M Day, Stefano Fedele, Vehid M Salih   +3 more
doaj   +1 more source

Key Triggers of Osteoclast-Related Diseases and Available Strategies for Targeted Therapies: A Review

Frontiers in Medicine, 2017
Osteoclasts, the only cells with bone resorption functions in vivo, maintain the balance of bone metabolism by cooperating with osteoblasts, which are responsible for bone formation.
Haidi Bi, Xing Chen, Song Gao, Xiaolong Yu, Jun Xiao, Bin Zhang, Xuqiang Liu, Min Dai   +7 more
doaj   +1 more source

Hepatocellular Carcinoma with Osteoclast-Like Giant Cells: Report of the Seventh Case in the Literature

Case Reports in Surgery, 2015
Hepatocellular carcinoma with osteoclast-like giant cells is extremely rare, and only six cases have been previously reported. Its histogenesis is at the moment controversial.
Lorenzo Dioscoridi, Damiano Bisogni, Giancarlo Freschi   +2 more
doaj   +1 more source

The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation

Journal of Pharmacological Sciences, 2012
Osteoclasts (OCLs) are multinucleated bone resorbing cells whose differentiation is regulated by receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF).
Reiko Fumimoto, Eiko Sakai, Yu Yamaguchi, Hiroshi Sakamoto, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto, Takayuki Tsukuba   +7 more
doaj   +1 more source

(−)-Epigallocatechin-3-Gallate Decreases Osteoclastogenesis via Modulation of RANKL and Osteoprotegrin

Molecules, 2019
Osteoporosis is the second most common epidemiologic disease in the aging population worldwide. Previous studies have found that frequent tea drinkers have higher bone mineral density and less hip fracture.
Shih-Tse Chen, Lin Kang, Chau-Zen Wang, Peng-Ju Huang, Hsuan-Ti Huang, Sung-Yen Lin, Shih-Hsiang Chou, Cheng-Chang Lu, Po-Chih Shen, Yi-Shan Lin, Chung-Hwan Chen   +10 more
doaj   +1 more source