Results 31 to 40 of about 169,031,329 (267)

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma [PDF]

, 2009
Proliferation and survival of Hodgkin and Reed/Sternberg (HRS) cells, the malignant cells of classical Hodgkin lymphoma (cHL), are dependent on constitutive activation of nuclear factor {kappa}B (NF-{kappa}B).
Inga Vater, Giefing, Maciej, Vater, Inga, Hartmann, Sylvia, Martin-Leo Hansmann, Martin-Subero, Jose Ignacio, Bohle, Verena, Küppers, Ralf, Jens Stanelle, Ralf Küppers, Sylvia Hartmann, Gunhild Mechtersheimer, Hansmann, Martin-Leo, Gesk, Stefan, Jose Ignacio Martin-Subero, Stanelle, Jens, Verena Bohle, Siebert, Reiner, Roland Schmitz, Klapper, Wolfram, Maciej Giefing, Wolfram Klapper, Mechtersheimer, Gunhild, Schmitz, Roland, Stefan Gesk, Reiner Siebert   +25 more
core   +1 more source

The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway. [PDF]

, 1998
The X gene product of the human hepatitis B virus (HBx) is a transcriptional activator of various viral and cellular genes. We recently have determined that the production of tumor necrosis factor-alpha (TNF-alpha) by HBV-infected hepatocytes is ...
Armesilla, Angel, Redondo, Juan Miguel, Lara-Pezzi, Enrique, Juan Miguel Redondo, López-Cabrera, Manuel, Pedro L. Majano, Armesilla, Angel L., Enrique Lara-Pezzi, Angel Luis Armesilla, Majano, Pedro L., Manuel López-Cabrera, Redondo, Juan M.   +11 more
core   +1 more source

The Role of Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the Chicken or the Egg Paradox

Balkan Medical Journal, 2018
Cardiovascular disease is one of the most frequent causes of mortality and morbidity worldwide. Several variables have been identified as risk factors for cardiovascular disease.
Flora Özkalaycı, Öykü Gülmez, Betül Uğur-Altun, Seithikurippu Ratnas Pandi-Perumal, Armağan Altun   +4 more
doaj   +1 more source

Human osteosarcoma cells express functional receptor activator of nuclear factor‐kappa B

The Journal of Pathology, 2007
AbstractRANK, RANK ligand (RANKL) and osteoprotegerin (OPG) are the key regulators of bone metabolism, both in normal and pathological conditions. Previous data have demonstrated that human osteosarcoma biopsies express RANKL as well as OPG, and functional RANK is expressed in a murine osteosarcoma cell line.
Mori, K., Le Goff, B., Berreur, M., Riet, A., Moreau, A., Blanchard, F., Chevalier, C., Guisle-Marsollier, I., Leger, J., Guicheux, J., Masson, M., Gouin, F., Redini, F., Heymann, D.   +13 more
openaire   +3 more sources

Myeloid IκBα deficiency promotes atherogenesis by enhancing leukocyte recruitment to the plaques. [PDF]

, 2011
Activation of the transcription factor NF-κB appears to be involved in different stages of atherogenesis. In this paper we investigate the role of NF-κB inhibitor IκBα in atherosclerosis.
Menno P J de Winther, Hofker Marten H., Hofker, Marten H., Rupec Rudolf A., Curfs Danielle M. J., Woezik, J.H.G. (Johannes H.) van, Hoeksema, Marten A., Goossens, P. (Pieter), Rudolf A Rupec, Hoeksema Marten A., Leenen, Pieter J. M., Leenen, P.J.M. (Pieter), Winther, M.P.J. (Menno P.) de, Marion J. J. Gijbels, Leenen Pieter J. M., Hoeksema, M.A. (Marten), Danielle M J Curfs, Pieter J M Leenen, Marten A. Hoeksema, Gijbels, Marion J. J., Vergouwe, Monique N., Gijbels, M. (Marion), Johannes H. G. van Woezik, Rupec, R.A. (Rudolf), Xanthouleas, Sofia, de Winther, Menno P. J., Gijbels Marion J. J., Monique N. Vergouwe, Xanthoulea Sofia, Goossens, Pieter, Curfs, Danielle M. J., Johannes H G van Woezik, Marten H. Hofker, van Woezik, Johannes H. G., Marion J J Gijbels, Xanthoulea, Sofia, Vergouwe, Y. (Yvonne), Xanthoulea, S. (Sofia), van Woezik Johannes H. G., Sofia Xanthoulea, Goossens Pieter, Vergouwe Monique N., Rupec, Rudolf A., Hofker, M.A. (Marten), Curfs, D.M.J. (Danielle M.), Marten A Hoeksema, Marten H Hofker, Pieter J. M. Leenen, Menno P. J. de Winther, Danielle M. J. Curfs, de Winther Menno P. J., Rudolf A. Rupec, Pieter Goossens, Monique N Vergouwe, Hofker, MH, Curfs, DMJ, Rupec, RA, van Woezik, JHG, Vergouwe, MN, Gijbels, MJJ, de Winther, MPJ, Goossens, P, Xanthoulea, S, Hoeksema, MA, Leenen, Pieter   +64 more
core   +4 more sources

RANK/RANKL/OPG system in the intervertebral disc

Arthritis Research & Therapy, 2017
Background The receptor activator of NF-κB ligand (RANKL), a member of the TNF ligand superfamily, is known to regulate bone metabolism. The expression of each component of the RANK/RANKL/osteoprotegerin (OPG) system in the intervertebral disc (IVD) has ...
Norihiko Takegami, Koji Akeda, Junichi Yamada, Tomohiko Sano, Koichiro Murata, Jenny Huang, Koichi Masuda, Akihiro Sudo   +7 more
doaj   +1 more source

p160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain [PDF]

, 2008
Transcriptional activation involves the ordered recruitment of coactivators via direct interactions between distinct binding domains and recognition motifs.
Coudevylle, N., Pfitzner, E., Muenz, Tobias, Pfitzner, Edith, Becker, Stefan, Coudevylle, Nicolas, Münz, Tobias, Lodrini, M., Becker, S., Munz, T., Griesinger, C., Lodrini, Marco, Griesinger, Christian   +12 more
core   +1 more source

Dieckol isolated from Eisenia bicyclis extract suppresses RANKL-induced osteoclastogenesis in murine RAW 264.7 cells

Asian Pacific Journal of Tropical Biomedicine, 2022
Objective: To demonstrate the effect of dieckol from Eisenia bicyclis on osteoclastogenesis using RAW 264.7 cells. Methods: Murine macrophage RAW 264.7 cells were subjected to dieckol treatment, followed by treatment with receptor activator of nuclear ...
Su-Hyeon Cho, Tae-Hyung Kwon, Hoibin Jeong, Jin Sook Kim, Song-Rae Kim, Myeong Seon Jeong, SeonJu Park, Miri Choi, Jung-Hee Woo, Juhee Ahn, Kil-Nam Kim   +10 more
doaj   +1 more source

The role of skeletal tissue remodeling markers in the patho-genesis of implant-associated inflammation after primary knee arthroplasty [PDF]

Саратовский научно-медицинский журнал, 2018
Aim: to reveal certain mechanisms of the pathogenesis of implant-associated inflammation by the level of resorption and bone tissue genesis markers in patients who underwent primary knee arthroplasty. Material and Methods.
Galashina Е.А., Bondarenko A.S., Ulyanov V.Yu., Klimov S.S.   +3 more
doaj  

OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D

Italian Journal of Pediatrics, 2019
Background Type 1 diabetes (T1D) has been associated with a higher fracture risk due to alterations in bone structure and metabolism. On the other hand, the important role of the RANKL/OPG/RANK signaling axis in bone physiology is well established.
Paraskevi Karalazou, Dimitrios Ntelios, Fani Chatzopoulou, Aikaterini Fragou, Maria Taousani, Konstantina Mouzaki, Assimina Galli-Tsinopoulou, Sofia Kouidou, Georgios Tzimagiorgis   +8 more
doaj   +1 more source