Results 51 to 60 of about 63,264 (143)

RANK (Receptor Activator of Nuclear Factor kappa B) and RANK Ligand Are Expressed in Giant Cell Tumors of Bone [PDF]

American Journal of Clinical Pathology, 2002
In giant cell tumors of bone (GCTBs), the mesenchymal stromal cells are the neoplastic cells and induce recruitment and formation of osteoclasts (OCs). Studies on recently discovered members of the tumor necrosis factor receptor-ligand family have demonstrated a crucial role of RANKL (receptor activator of nuclear factor kappa B [RANK] ligand ...
Sophie, Roux, Larbi, Amazit, Geri, Meduri, Anne, Guiochon-Mantel, Edwin, Milgrom, Xavier, Mariette   +5 more
openaire   +2 more sources

Generation and Purification of RANKL-Derived Small-Fragment Variants for Osteoclast Inhibition

Pharmaceutics
Background/Objectives: Osteoporosis is caused by excessive osteoclast activation via the receptor activator nuclear factor kappa B ligand (RANKL), which is released from osteoblasts or osteocytes.
Hyungjun Lee, Hyungseok Park, Kabsun Kim, Youngjong Ko, Chang-Moon Lee, Wonbong Lim   +5 more
doaj   +1 more source

Antibodies to receptor activator of nuclear factor-kappa B ligand (RANKL)

, 2008
Patent WO02095012A1 claims for the development of antibodies against receptor activator of nuclear factor-kappa B ligand (RANKL) and immunologically functional fragments that neutralize RANKL. These molecules can be used to detect RANKL in biological samples, allowing the identification of pathological conditions in which RANKL alteration contributes ...
Terpos, Evangelos, Christoulas, Dimitrios, Dimopoulos, Meletios-Athanassios   +3 more
openaire   +4 more sources

Role of osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear...

, 2018
Concomitantly with the increase in the prevalences of overweight/obesity, nonalcoholic fatty liver disease (NAFLD) has worldwide become the main cause of chronic liver disease in both adults and children. Patients with fatty liver display features of metabolic syndrome (MetS), like insulin resistance (IR), glucose intolerance, hypertension and ...
Pacifico L, Andreoli GM, D'Avanzo M, Mitri DD, Pierimarchi P   +4 more
openaire   +1 more source

Soluble Expression and Purification of Receptor Activator of Nuclear Factor-Kappa B Ligand Using Escherichia coli

Journal of Microbiology and Biotechnology, 2015
Receptor activator of nuclear factor-kappa B ligand (RANKL) is a critical factor in osteoclastogenesis. It makes osteoclasts differentiate and multinucleate in bone remodeling. In the present study, RANKL was expressed as a soluble maltose binding protein (MBP)-fusion protein using the Escherichia coli maltose binding domain tag system (pMAL ...
Sol-Ji, Park, Se-Hoon, Lee, Kwang-Jin, Kim, Sung-Gun, Kim, Hangun, Kim, Han, Choe, Sang Yeol, Lee, Jung-Mi, Yun, Jae Youl, Cho, Jiyeon, Chun, Kap Seong, Choi, Young-Jin, Son   +11 more
openaire   +2 more sources

High molecular weight hyaluronic acid alleviates ovariectomy-induced bone loss in mice

BMC Musculoskeletal Disorders
Background The rapid decline in ovarian function associated with menopause promotes osteoclast differentiation and increases bone resorption, disrupting of bone homeostasis and increasing the risk of osteoporosis. Hyaluronic acid (HA) is a polysaccharide
Khangarid Tenger, Keiichiro Komori, Ami Maehara, Kyosuke Miyazaki, Eriko Marukawa, Toshitaka Yoshii, Kunikazu Tsuji   +6 more
doaj   +1 more source

The Role of TNF-α and TNF Superfamily Members in the Pathogenesis of Calcific Aortic Valvular Disease

The Scientific World Journal, 2013
Calcific aortic valve disease (CAVD) represents a slowly progressive pathologic process associated with major morbidity and mortality. The process is characterized by multiple steps: inflammation, fibrosis, and calcification.
Antonella Galeone, Domenico Paparella, Silvia Colucci, Maria Grano, Giacomina Brunetti   +4 more
doaj   +1 more source

Expression of receptor activator of nuclear factor kappa B ligand in bladder cancer [PDF]

International Journal of Urology, 2018
Mari, Ohtaka, Takashi, Kawahara, Yukari, Ishiguro, Meenal, Sharma, Masahiro, Yao, Hiroshi, Miyamoto, Hiroji, Uemura   +6 more
openaire   +2 more sources

Magnesium Lithospermate B Protects against Lipopolysaccharide-Induced Bone Loss by Inhibiting RANKL/RANK Pathway

Frontiers in Pharmacology, 2018
Lipopolysaccharide (LPS) can induce bone loss by stimulating bone resorption. Natural compounds have great potential for the treatment of osteolytic bone diseases.
Jihai Wang, Xuejian Wu, Yongzhuang Duan
doaj   +1 more source

Microenvironmental Drivers of Bone Disease in Multiple Myeloma: Oxidative Stress, Sterile Inflammation, Autophagy–Lysosomal Remodeling, and the Iron–Lipid Peroxidation Axis

Biomolecules
Multiple myeloma profoundly remodels the bone marrow microenvironment, causing osteolytic bone disease through a persistent uncoupling of bone resorption and formation. Beyond the canonical roles of the receptor activator of nuclear factor kappa-B ligand/
Maria Elisa Nasso, Adele Bottaro, Manlio Fazio, Fabio Stagno, Sebastiano Gangemi, Alessandro Allegra   +5 more
doaj   +1 more source