Results 41 to 50 of about 63,264 (143)

The Role of Receptor Activator of Nuclear Factor Kappa B (RANK) and Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) in Osteoporosis Risk: Gene Polymorphism and Soluble RANKL Level in Indonesia Post-Menopausal Women [PDF]

OnLine Journal of Biological Sciences, 2018
Hormonal changes in postmenopausal women may increase osteoclastogenesis that can lead to increased risk of osteoporosis. Receptor Activator of Nuclear factor Kappa B (RANK) and Receptor Activator of Nuclear factor Kappa B Ligand (RANKL) have an important role in osteoclastogenesis that involve in the regulation of bone resorption.
Luluk Yunaini, Dwi Anita Suryandari, Linda Kusdhany, Mala Kurniati, Indhina Reihannisha, Elza Ibrahim Auerkari   +5 more
openaire   +1 more source

The RANKL-RANK Axis: A Bone to Thymus Round Trip

Frontiers in Immunology, 2019
The identification of Receptor activator of nuclear factor kappa B ligand (RANKL) and its cognate receptor Receptor activator of nuclear factor kappa B (RANK) during a search for novel tumor necrosis factor receptor (TNFR) superfamily members has ...
Cristina Sobacchi, Cristina Sobacchi, Ciro Menale, Ciro Menale, Anna Villa, Anna Villa   +5 more
doaj   +1 more source

Activation of Toll‐like receptor 9 inhibits lipopolysaccharide‐induced receptor activator of nuclear factor kappa‐ B ligand expression in rat B lymphocytes [PDF]

Microbiology and Immunology, 2014
ABSTRACTB lymphocytes express multiple TLRs that regulate their cytokine production. We investigated the effect of TLR4 and TLR9 activation on receptor activator of NF‐κB ligand (RANKL) expression by rat spleen B cells. Splenocytes or purified spleen B cells from Rowett rats were cultured with TLR4 ligand Escherichia coli LPS and/or TLR9 ligand CpG ...
Xiaoqian, Yu, Jiang, Lin, Qing, Yu, Toshihisa, Kawai, Martin A, Taubman, Xiaozhe, Han   +5 more
openaire   +2 more sources

Glycogen Synthase Kinase-3 Beta (GSK3β) as a Potential Drug Target in Regulating Osteoclastogenesis: An Updated Review on Current Evidence

Biomolecules
Glycogen synthase kinase 3-beta (GSK3β) is a highly conserved protein kinase originally involved in glucose metabolism, insulin activity, and energy homeostasis.
Sok Kuan Wong
doaj   +1 more source

Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-κB and mitogen-activated protein kinase pathways

BMC Complementary and Alternative Medicine, 2018
Background Radix Paeoniae Rubra (RPR), a traditional Chinese herb, has anti-inflammatory and immuno-regulatory properties. This study explored the effects of RPR on stimulation of osteoclast differentiation in RAW264.7 cells and peripheral blood ...
Huey-En Tzeng, Chun-Hao Tsai, Tin-Yun Ho, Chin-Tung Hsieh, Shen-Chieh Chou, Yi-Ju Lee, Gregory J. Tsay, Po-Hao Huang, Yi-Ying Wu   +8 more
doaj   +1 more source

Evaluation of Behavior and Expression of Receptor Activator of Nuclear Factor-Kappa B Ligand in Dorsal Root Ganglia after Sciatic Nerve Compression and Application of Nucleus Pulposus in Rats [PDF]

Asian Spine Journal, 2014
Study DesignExperimental animal study.PurposeTo evaluate pain-related behavior and changes in nuclear factor-kappa B (NF-kB), receptor activator of NF-kB (RANK), and ligand (RANKL) in dorsal root ganglia (DRG) after combined sciatic nerve compression and
Yoshiyuki Matsuyama, Yoshihiro Sakuma, Miyako Suzuki, Sumihisa Orita, Kazuyo Yamauchi, Gen Inoue, Yasuchika Aoki, Tetsuhiro Ishikawa, Masayuki Miyagi, Hiroto Kamoda, Gou Kubota, Yasuhiro Oikawa, Kazuhide Inage, Takeshi Sainoh, Jun Sato, Junichi Nakamura, Tomoaki Toyone, Kazuhisa Takahashi, Seiji Ohtori   +18 more
doaj   +1 more source

NEW ASPECTS IN DIAGNOSIS AND TREATMENT OF OSTEOPOROSIS

Zdravniški Vestnik, 2018
Background. Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk.
Damir Franić
doaj   +1 more source

Fracture risks and their mechanisms in atopic dermatitis, focusing on receptor activator of nuclear factor kappa-B ligand

Clinical and Experimental Dermatology, 2023
Abstract Recent multiple studies have shown that the long-term consequences of atopic dermatitis (AD) include an increased risk of osteoporosis and fracture, especially an increase in hip, pelvic, spinal and wrist fractures. AD is very common worldwide, and some kinds of fractures, such as hip fractures, are associated with increased ...
openaire   +2 more sources

Receptor activator of nuclear factor kappa B ligand (RANKL) levels in peri-implant crevicular fluid.

Iranian journal of immunology : IJI, 2010
Receptor activator of nuclear factor kappa B ligand (RANKL) is one of the key cytokines in the induction of osteoclastogenesis both in vitro and in vivo. Several reports indicated the presence of sRANKL in gingival crevicular fluid of patients with periodontal diseases.To determine the presence of RANKL in peri-implant crevicular fluid samples of ...
Sarlati, Fatemeh, Sattari, Mandana, Ghorbani Gazar, Ali, Nabavizadeh Rafsenjani, Ali   +3 more
openaire   +2 more sources

Macrophage Activation: Role of Toll-like Receptors, Nitric Oxide, and Nuclear Factor kappa B

American Journal of Pharmaceutical Education, 2006
Macrophages play an important role in host-defense and inflammation. In response to an immune challenge, macrophages become activated and produce proinflammatory mediators that contribute to nonspecific immunity. The mediators released by activated macrophages include: superoxide anion; reactive nitrogen intermediates, such as nitric oxide and ...
openaire   +3 more sources