Results 61 to 70 of about 59,132 (205)

Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19

Frontiers in Immunology, 2023
IntroductionThere remains a need to better identify patients at highest risk for developing severe Coronavirus Disease 2019 (COVID-19) as additional waves of the pandemic continue to impact hospital systems.
Zachary A. Matthay, Alexander T. Fields, Katherine D. Wick, Katherine D. Wick, Chayse Jones, Chayse Jones, H. Clifford Lane, Kimberly Herrera, Brenda Nuñez-Garcia, Efstathios Gennatas, Carolyn M. Hendrickson, Aaron E. Kornblith, Michael A. Matthay, Michael A. Matthay, Lucy Z. Kornblith, the COVID-19 Associated Coagulopathy Inflammation Thrombosis (Co-ACIT) Study Group, Biniam Ambachew, Roland J. Bainton, Sarah Cary, Lauren Chalwell, Christopher Colwell, Clayton Josephy, Philip Kurien, Deanna Lee, Matthieu LeGrand, Juan Carlos Montoy, Viet Nguyen, John J. Park, Arun Prakash, Brittany Robinson, Shelley India   +30 more
doaj   +1 more source

Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? [PDF]

, 2014
Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell ...
Chuluyan, Hector Eduardo, Gallo, Juan Eduardo Maria, Ortiz, Gustavo Alfredo, Salica, Juan Pablo   +3 more
core   +1 more source

Polymorphism of the RAGE Affects the Serum Inflammatory Levels and Risk of Ischemic Stroke in a Chinese Population

Cellular Physiology and Biochemistry, 2013
Background: Increasing evidence shows that inflammation plays an important role in the occurrence and progression of acute ischemic stroke. The receptor for advanced glycation end products (RAGE) has been documented to involve in the pathogenic ...
XiaoPing Cui, HongJie Chen, Xuwei Hou, ShouSen Wang, Shoba Jayaram, ZhaoCong Zheng   +5 more
doaj   +1 more source

FPS-ZM1 Alleviates Circulating Indices of Liver Injury in Diet-Induced Type 2 Diabetic Mice

Acta Medica Iranica, 2022
Despite dietary/lifestyle modifications as well as glycemic and lipid control, non-alcoholic fatty liver disease (NAFLD) imposes a considerable risk to the patients by advancing to non-alcoholic steatohepatitis (NASH).
Somayeh Aslani, Saman Bahrambeigi, Davoud Sanajou   +2 more
doaj   +1 more source

Advanced Glycation End-Products and Their Receptor-Mediated Roles: Inflammation and Oxidative Stress [PDF]

Iranian Journal of Medical Sciences, 2011
Glycation is a protein modification, which results in a change in a protein structure. Glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and Alzheimer’s disease (AD).
Parisa Younessi, Ali Younessi
doaj  

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)

Endocrinology, Diabetes & Metabolism, 2021
Aims The accumulation of advanced glycation end products is implicated in the development and progression of diabetic kidney disease. No study has examined whether stimulating advanced glycation clearance via receptor manipulation is reno‐protective in ...
Aowen Zhuang, Felicia Y. T. Yap, Danielle J. Borg, Domenica McCarthy, Amelia Fotheringham, Sherman Leung, Sally A. Penfold, Karly C. Sourris, Melinda T. Coughlan, Benjamin L. Schulz, Josephine M. Forbes   +10 more
doaj   +1 more source

Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function [PDF]

, 2009
Background Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders.
Bjoerk, Per, Bronstein, Igor B., Burkitt, William I., Derrick, Peter J., Foell, Dirk, He, Wei, Ianoul, Anatoli, Lednev, Igor K., Moroz, Olga V., Novitskaya, Vera, Polyakova, Oxana, Shekhtman, Alexander, Wittkowski, Helmut, Xie, Jingjing   +13 more
core   +4 more sources

Receptor for advanced glycation end-products-mediated inflammation and diabetic vascular complications [PDF]

Journal of Diabetes Investigation, 2011
Exposure of amino residue of proteins to reducing sugars, such as glucose, glucose 6‐phosphate, fructose, ribose and intermediate aldehydes, results in non‐enzymatic glycation, which forms reversible Schiff bases and Amadori compounds. A series of further complex molecular rearrangements then yield irreversible advanced glycation end‐products (AGE ...
Yamamoto, Yasuhiko, Yamamoto, Hiroshi
openaire   +2 more sources

Receptor for Advanced Glycation End Products and Age-Related Macular Degeneration

Investigative Opthalmology & Visual Science, 2004
Advanced glycation end products (AGE) exacerbate disease progression through two general mechanisms: modifying molecules and forming nondegradable aggregates, thus impairing normal cellular/tissue functions, and altering cellular function directly through receptor-mediated activation.
Kimberly A, Howes, Yang, Liu, Joshua L, Dunaief, Ann, Milam, Jeanne M, Frederick, Alexander, Marks, Wolfgang, Baehr   +6 more
openaire   +2 more sources

Explore the mechanism of puerarin to improve diabetic peripheral neuropathy in rats based on AGEs/RAGE signaling pathway [PDF]

Yixue xinzhi zazhi
Objective To explore the ameliorative effect of puerarin on diabetic peripheral neuropathy (DPN) in rats and its possible mechanism.Methods A total of 50 SD rats were randomly divided into control group, model group (DPN model was constructed), low-dose ...
HAO Lu, SHI Mingyang, CHEN Yan, YANG Shan   +3 more
doaj   +1 more source