Results 211 to 220 of about 396,884 (345)

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

One step further in targeting acute leukemia by combining antibody-based immunotherapies and small molecule inhibitors. [PDF]

Cancer Cell Int
Dozandeh-Jouybari A, Rohaninia E, Faaliat S, Joudaki N, Ghandi S, Moghaddam MT, Taghiloo S, Kazemi T.   +7 more
europepmc   +1 more source

Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis

Advanced Science, EarlyView.
Weight cycling in Humans is suspected to dysregulate eating behavior. Mice submitted to body weight cycling by alternating western‐type and regular chow diets display increased hedonic appetite when exposed to a palatable diet, reminiscent of binge‐eating episodes.
Mélanie Fouesnard, Adélie Salin, Sandy Ribes, Magali Monnoye, Gaëlle Champeil‐Potokar, Marie‐Sabelle Hjeij, Gwénaëlle Randuineau, Léa Le Gleau, Selma Ben Fradj, Catherine Philippe, Alexandre Benani, Isabelle Denis, Véronique Douard, Gaëlle Boudry   +13 more
wiley   +1 more source

Advances in research on unphosphorylated STAT3: A review. [PDF]

Medicine (Baltimore)
Zhang L, Guo W, Lu N, Tian Y, Yang J, Wang L.   +5 more
europepmc   +1 more source

syk protein tyrosine kinase regulates Fc receptor gamma -chain-mediated transport to lysosomes

, 1998
Christian Bonnerot
openalex   +2 more sources

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Immune Checkpoint Blockade in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
IGF1R is highly expressed in the armored & cold tumors, and collagen mediates IGF1R at the transcriptional and post‐translational levels to promote TNBC cell invasion and immune escape and to stabilize its own structure by interacting with the collagen receptor DDR1.
Mengyun Wan, Jie Mei, Yun Cai, Ji Zhou, Ningyi Xue, Ying Jiang, Yan Zhang, Jingjing Huang, Yichao Zhu   +8 more
wiley   +1 more source

Substituted Triazole-3,5-Diamine Compounds as Novel Human Topoisomerase III Beta Inhibitors. [PDF]

Int J Mol Sci
Mamun Y, Chadni SH, Rayala R, Shafi H, Ferdous S, Pokhrel R, Nefzi A, Chapagain P, Tse-Dinh YC.   +8 more
europepmc   +1 more source

Regulation of T-Cell Antigen Receptor Signalling by Syk Tyrosine Protein Kinase

, 1997
Sylvain Latour, Marielle Fournel, André Veillette   +2 more
openalex   +1 more source

c-Src Tyrosine Kinase Binds the β2-Adrenergic Receptor via Phospho-Tyr-350, Phosphorylates G-protein-linked Receptor Kinase 2, and Mediates Agonist-induced Receptor Desensitization [PDF]

, 2001
Gaofeng Fan, Elena Shumay, Craig C. Malbon, Hsien‐yu Wang   +3 more
openalex   +1 more source

Aligned Conductive Magnetic Nanofibers with Directional Magnetic Field Stimulation Promotes Peripheral Nerve Regeneration

Advanced Science, EarlyView.
Peripheral nerve injury necessitates alternatives to autografts. This study combines magnetic nanoparticles, oriented PCL fibers, and Ppy to create a conductive, magnetically active scaffold. In vitro and in vivo experiments demonstrated enhanced downstream pathways of calcium signaling, as revealed by transcriptome analysis.
Zheyuan Fan, Wei Yu, Xinggui Wen, Xiangdong Ding, Xiang Li   +4 more
wiley   +1 more source