Results 221 to 230 of about 167,856 (315)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

DeepKinome: quantitative prediction of kinase binding affinity by a compound using deep learning based regression model. [PDF]

Front Mol Biosci
Lee Y, Eun J, Lee J, Nam S.
europepmc   +1 more source

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source

The immune receptor FcRγ-chain mediates CD36-induced platelet activation and thrombosis by oxidized low-density lipoproteins. [PDF]

Blood Adv
Wraith KS, Khalil JS, Aburima AA, Cheah LT, Hindle MS, Berger M, Uddin R, Ayub H, McKay M, Xu RG, Ariëns RAS, Kearney MT, Tomlinson MG, Naseem KM.   +13 more
europepmc   +1 more source

Scaffolding Protein Gab2 Mediates Differentiation Signaling Downstream of Fms Receptor Tyrosine Kinase

, 2001
Yan Liu, Brendan J. Jenkins, Jung Lim Shin, Larry R. Rohrschneider   +3 more
openalex   +1 more source

Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Advanced Science, EarlyView.
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr., Georgii B. Telegin, Aleksandr S. Chernov, Anna A. Kudriaeva, Alexey N. Minakov, Maksim V. Rodionov, Vitaly A. Kazakov, Viktor A. Palikov, Yuri M. Poluektov, Rustam H. Ziganshin, Daria A. Orlova, Alena S. Evpak, Daniil A. Barsuk, Fedor A. Mesheryakov, Aldo Spallone, Dmitry S. Asyutin, Igor N. Pronin, Nikolay A. Konovalov, Dmitri Yu Usachev, Alexander G. Gabibov, Alexander N. Konovalov   +20 more
wiley   +1 more source

Tyrosine phosphorylation by the epidermal growth factor receptor kinase induces functional alterations in microtubule-associated protein 2.

, 1987
Eisuke Nishida, Minako Hoshi, Yoshihiko Miyata, Hikoichi Sakai, Takashi Kadowaki, Masato Kasuga, Shinobu Saijo, Hiroshi Ogawara, Tetsu Akiyama   +8 more
openalex   +1 more source

SLPI⁺ AT2‐Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche

Advanced Science, EarlyView.
Integrating spatial transcriptomics and single‐cell RNA sequencing, this study identifies a novel subpopulation of SLPI⁺ AT2‐like cells at the invasive margin of lung adenocarcinoma (LUAD). These cells, through stromal crosstalk and Wnt pathway activation, promote tumor stemness and invasion.
Zhoufeng Wang, Guonian Zhu, Pan Tang, Yan Wang, Wenxin Luo, Wenpeng Song, Zhikang Pan, Bingjie Zheng, YongChao Jiang, Defu Xiao, Xin Jin, Yong Bai, Guowei Che, Weimin Li   +13 more
wiley   +1 more source

Preoperative Activation of c-Src Kinase in Atrial Tissue in Patients Developing Postoperative Atrial Fibrillation. [PDF]

Medicina (Kaunas)
Bonda TA, Dziemidowicz M, Hirnle T, Dmitruk I, Bialuk I, Winnicka MM.   +5 more
europepmc   +1 more source