Results 221 to 230 of about 156,578 (338)

Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases. [PDF]

Cell Commun Signal
Hamoud AR, Alganem K, Hanna S, Morran M, Henkel N, Imami AS, Ryan W, Sahay S, Pulvender P, Kunch A, Arvay TO, Meller J, Shukla R, O'Donovan SM, McCullumsmith R.   +14 more
europepmc   +1 more source

Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase β

, 1998
Sacha J. Holland, Elior Peles, Tony Pawson, Joseph Schlessinger   +3 more
openalex   +1 more source

Substrates of semicarbazide-sensitive amine oxidase co-operate with vanadate to stimulate tyrosine phosphorylation of insulin-receptor-substrate proteins, phosphoinositide 3-kinase activity and GLUT4 translocation in adipose cells [PDF]

, 2000
Gemma Enrique-Tarancón, Isabelle Castan‐Laurell, Nathalie Morin, Luc Marti, Anna Abella, Marta Camps, Roser Casamitjana, Manuel Palacı́n, Xavier Testar, Eva Degerman, Christian Carpéné, António Zorzano   +11 more
openalex   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Temporal characterisation and electrophysiological implications of TBI-induced serine/threonine kinase activity in mouse cortex. [PDF]

Cell Mol Life Sci
Celine G, Thomas M.
europepmc   +1 more source

Stimulation of the Mitogen-activated Protein Kinase Cascade and Tyrosine Phosphorylation of the Epidermal Growth Factor Receptor by Hepatopoietin [PDF]

, 2000
Yong Li, Ming Li, Guichun Xing, Zhiyuan Hu, Qingming Wang, Chunna Dong, Handong Wei, Fan Guocai, Jizhong Chen, Xiaoming Yang, Shi-Fu Zhao, Huipeng Chen, Kun‐Liang Guan, Chutse Wu, Chenggang Zhang, Fuchu He   +15 more
openalex   +1 more source

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source

Target Agnostic Photoaffinity Labelling by Sulfonylhydrazones

Angewandte Chemie, EarlyView.
Sulfonyl hydrazones were identified as new photo‐crosslinkers exploiting their base catalyzed low‐energy photoactivation that leads to reactive carbenes. The amino acid promiscuity, their usefulness in proteomics application and the range of labelled targets including enzymes, a PPI target and a transcription factor suggests that sulfonyl hydrazones ...
Kristóf Garami, Nikolett Péczka, László Petri, Tímea Imre, Tamás Langó, Zoltán Szabó, Zoltán Orgován, Pál Szabó, György Miklós Keserü, Péter Ábrányi‐Balogh   +9 more
wiley   +2 more sources

Fibrosis and Src Signalling in Glaucoma: From Molecular Pathways to Therapeutic Prospects. [PDF]

Int J Mol Sci
Bourke L, O'Brien C.
europepmc   +1 more source

Mediation by the Protein-tyrosine Kinase Tec of Signaling between the B Cell Antigen Receptor and Dok-1 [PDF]

, 2000
Koji Yoshida, Yoshihiro Yamashita, Akira Miyazato, Ken‐ichi Ohya, Akira Kitanaka, Uichi Ikeda, Kazuyuki Shimada, Takeo Yamanaka, Keiya Ozawa, Hiroyuki Mano   +9 more
openalex   +1 more source