Results 221 to 230 of about 514,942 (384)

Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

Advanced Science, EarlyView.
Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee, Jiamin Li, Nan‐Peng Chen, Cheng‐han Yu   +3 more
wiley   +1 more source

Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery. [PDF]

Signal Transduct Target Ther
Wu X, Yang Z, Zou J, Gao H, Shao Z, Li C, Lei P.   +6 more
europepmc   +1 more source

Association of the High-Affinity Receptor for IgG with the Protein Tyrosine Kinases Hck and Lyn [PDF]

, 1995
Amu Wang, Paul Scholl, Raif S. Geha
openalex   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer. [PDF]

NPJ Precis Oncol
Rix B, Chauhan R, Masoumi Z, Grönroos E, Brain CE, Ogunbiyi OK, Swarbrick K, Swanton C, Bonnet D, Kurzawinski TR, Izatt L, McDonald NQ, Grey W.   +12 more
europepmc   +1 more source

Staphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein-tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription (Stat proteins).

, 1995
Michael Engelbrecht Nielsen, Arne Svejgaard, C. Röpke, Mette Nordahl, N Odum   +4 more
openalex   +1 more source

Identification of an Atypical Grb2 Carboxyl-terminal SH3 Domain Binding Site in Gab Docking Proteins Reveals Grb2-dependent and -independent Recruitment of Gab1 to Receptor Tyrosine Kinases [PDF]

, 2000
Lisa Lock, Isabelle Royal, Monica A. Naujokas, Morag Park   +3 more
openalex   +1 more source

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Cell, 1992
E. Lowenstein, R. Daly, A. Batzer, W. Li, B. Margolis, Richard L. Lammers, A. Ullrich, E. Skolnik, D. Bar-Sagi, J. Schlessinger   +9 more
semanticscholar   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Repurposing of the Syk inhibitor fostamatinib using a machine learning algorithm. [PDF]

Exp Ther Med
Choi Y, Lee H, Beck BR, Lee B, Lee JH, Kim S, Chun SH, Won HS, Ko YH.   +8 more
europepmc   +1 more source