Results 251 to 260 of about 514,942 (384)

Functional kinome profiling reveals brain protein kinase signaling pathways and gene networks altered by acute voluntary exercise in rats. [PDF]

PLoS One
Lee CM, Nguyen J, Pope B, Imami AS, Ryan VWG, Sahay S, Mathis V, Pulvender P, Eby HM, Arvay T, Alganem K, Wegman-Points L, McCullunsmith R, Yuan LL.   +13 more
europepmc   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Vav3 Mediates Receptor Protein Tyrosine Kinase Signaling, Regulates GTPase Activity, Modulates Cell Morphology, and Induces Cell Transformation [PDF]

, 2000
Liyu Zeng, Perminder S. Sachdev, LunBiao Yan, Joseph L.‐K. Chan, Thomas Trenkle, Michael McClelland, John Welsh, Lu‐Hai Wang   +7 more
openalex   +1 more source

RNF213-Dependent EGFR and HER2 Activation Regulates Specific Downstream Signaling Pathways in Human Cancer Cells. [PDF]

Genes Cells
Fouad IM, Choi J, Huang Q, Kim M, Masuda S, Hejna JA, Mineharu Y, Koizumi A, Tezuka T, Youssefian S.   +9 more
europepmc   +1 more source

Co-ordination of the expression of the protein tyrosine kinase p56lck with the pre-T cell receptor during thymocyte development [PDF]

, 2000
Jennifer Buckland, Daniel J. Pennington, Ludovica Bruno, Michael J. Owen   +3 more
openalex   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Pharmacokinomic Profiling Using Patient-Derived Cell Lines Predicts Sensitivity to Imatinib in Dermatofibrosarcoma Protuberans. [PDF]

Cells
Noguchi R, Ono T, Sasaki K, Masuda M, Kawai A, Yoshimatsu Y, Kondo T.   +6 more
europepmc   +1 more source

syk protein tyrosine kinase regulates Fc receptor gamma -chain-mediated transport to lysosomes

, 1998
Christian Bonnerot
openalex   +2 more sources

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo, Kexin Tong, Yeting Gan, Min Tang, Yuguo Niu, Kan Liu, Shihong Ni, Shangming Wu, Xiaoxue Jiang, Haizhou Jiang, Fei Xiao, Shanghai Chen, Wei Lv, Xiaoying Li, Feixiang Yuan, Feifan Guo   +15 more
wiley   +1 more source

MicroRNAs as Sensitizers of Tyrosine Kinase Inhibitor Resistance in Cancer: Small Molecule Partnerships. [PDF]

Pharmaceuticals (Basel)
Campos-Parra AD, Sánchez-Marín D, Acevedo-Sánchez V.   +2 more
europepmc   +1 more source