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Targeting HER2-Positive HCC1954 Breast Cancer Cells by Novel Thiazole-Dihydrobenzisoxazoles: In-Depth Design, Synthesis and Initial <i>In Vitro</i> Study. [PDF]
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Membrane receptors with protein-tyrosine kinase activity
Biochimie, 1987Protein-tyrosine kinase activities have appeared so far to be intrinsic for two classes of proteins: the transforming proteins of certain retroviral oncogenes and the membrane receptors for certain cellular growth factors. In this latter family, the protein-tyrosine kinase is activated upon binding of the growth factor to its receptor and ...
J J, Feige, E M, Chambaz
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Vertebrate non‐receptor protein–tyrosine kinase families
Genes to Cells, 1996Many non‐receptor protein–tyrosine kinases (PTKs) function as subunits of receptors, either receptors with or without intrinsic PTK catalytic activity of their own. There are currently at least 33 known vertebrate genes that encode non‐receptor PTKs.
K, Neet, T, Hunter
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Non-receptor protein tyrosine kinases
Frontiers in Bioscience, 2003The protein tyrosine kinases (PTKs) are enzymes catalyzing the transfer of the gamma-phosphate group of ATP to the hydroxyl groups of specific tyrosine residues in peptides. Although phosphotransfer reactions catalyzed by various PTKs are similar with regard to their basic mechanisms, their biological functions demonstrate a considerable degree of ...
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Comparative characterization of receptor and non-receptor associated protein tyrosine kinases
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1989By using poly(Glu: Tyr, 4:1) as an exogenous substrate, the characteristics of insulin receptor associated protein tyrosine kinase (PTK) from rabbit skeletal muscle has been compared with a growth factor-independent non-receptor PTK partially purified from rat lung particulate fraction.
A K, Srivastava, J L, Chiasson
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src-related protein tyrosine kinases and their surface receptors
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1993The CD4-p56lck and CD8-p56lck complexes have served as a paradym for an expanding number of interactions between src-family members (p56lck, p59fyn, p56lyn, p55blk) and surface receptors. These interactions implicate src-related kinases in the regulation of a variety of intracellular events, from lymphokine production and cytotoxicity to the expression
Telfer, Janice T. +6 more
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VEGF receptor protein–tyrosine kinases: Structure and regulation
Biochemical and Biophysical Research Communications, 2008The human VEGF family consists of VEGF (VEGF-A), VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF). The VEGF family of receptors consists of three protein-tyrosine kinases (VEGFR1, VEGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and neuropilin-2).
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Signalling pathways operated by receptor protein tyrosine kinases
2002The first RTK discovered was the EGFR. It was also the first receptor that provided evidence for a relationship between activating mutations (oncogenes) and cancer. About 90 genes code for protein tyrosine kinases in the human genome, out of which 58 are receptors (rPTK) and are classified into 20 subfamilies.
Bastien D. Gomperts +2 more
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Regulation of antigen receptor signal transduction by protein tyrosine kinases
Current Opinion in Immunology, 1996The past two years have seen further clarification of the early events occurring in antigen receptor signal transduction that are mediated by the immunoreceptor tyrosine-based activation motif (ITAM). The ITAM was shown to be a specific binding site for the ZAP-70/Syk protein tyrosine kinases and the structure of this complex was solved.
A C, Chan, A S, Shaw
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