Results 151 to 160 of about 86,953 (229)

Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT I describe my progress in understanding synaptic plasticity in the hippocampus. Over the decades my lab has focused on the roles of glutamate receptors (AMPARs, NMDARs, mGluRs and KARs) and associated signaling molecules in LTP and LTD. Most of our studies have been conducted in area CA1 (Schaffer collateral—commissural pathway) with some ...
Graham L. Collingridge
wiley   +1 more source

Glutamate Receptor Agonists as Triggers of Neurotoxicity: Decoding Pathways of Five Neurotoxins and Potential Therapeutic Targets. [PDF]

ACS Omega
Turcatel GA, Moura S.
europepmc   +1 more source

A Novel NLRP3 Inhibitor AMS‐17 Rescues Deficits in Long‐Term Potentiation Following Mild Traumatic Brain Injury in Adult C57Bl/6 Mice

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT Traumatic brain injury (TBI) is a leading cause of long‐term disability, with limited effective treatment options. A key factor of TBI pathophysiology is neuroinflammation, which can involve the activation of the nucleotide‐binding domain leucine‐rich repeat protein 3 (NLRP3) inflammasome. Aberrant inflammation following injury has the ability
Eric Eyolfson, Luis Bettio, Justin Brand, Naveen Kumar Gupta, Emily Hamer, Ryan Salas, Amol Kulkarni, Brian R. Christie   +7 more
wiley   +1 more source

Neurological diversity and generalizability: building on AMPA receptor imaging advances in long COVID. [PDF]

Brain Commun
Rudroff T.
europepmc   +1 more source

Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti‐Related Peptide (NPY/AgRP) Neurons

Obesity, Volume 34, Issue 1, Page 175-187, January 2026.
ABSTRACT Objective Topiramate is a medication used off‐label, or in combination with phentermine, for the management of obesity. However, its mechanism of action remains elusive. As many obesity medications target the brain, we aimed to determine if topiramate influences the activity of hypothalamic melanocortin neurons known to regulate energy balance.
Moein Minbashi Moeini, Olivier Lavoie, Alexandre Caron, Kevin W. Williams, Natalie J. Michael   +4 more
wiley   +1 more source

Serotonergic Suppression of Sustained Synaptic Responses in Rat Oculomotor Neural Integrator Networks. [PDF]

eNeuro
Saito Y, Sugimura T.
europepmc   +1 more source

Refractory Peripheral Pulmonary Stenosis and Severe Pulmonary Arterial Hypertension Associated With a De Novo Loss‐of‐Function Variant in FGD5

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT We report a novel genetic variant in a patient with treatment‐resistant peripheral pulmonary artery stenosis (PPS) and progressive pulmonary arterial hypertension (PAH). A premature infant was diagnosed with bilateral PPS requiring multiple surgical reconstructions and interventional procedures with refractory proximal stenoses.
Lea C. Steffes, Gregory T. Adamson, Kyla E. Dunn, Jeffrey A. Feinstein   +3 more
wiley   +1 more source

Centrally administered thromboxane A₂ analogue facilitates the micturition reflex in rats. [PDF]

Sci Rep
Hamada C, Shimizu T, Togo M, Higashi Y, Shimizu N, Furumiya J, Saito M.   +6 more
europepmc   +1 more source

Genetic Reduction of the Translational Repressors FMRP and 4E‐BP2 Preserves Memory in Mouse Models of Alzheimer's Disease

Aging Cell, Volume 25, Issue 1, January 2026.
Genetic reduction of the translational repressors FMRP or 4E‐BP2 prevents amyloid‐β oligomer–induced suppression of hippocampal protein synthesis and memory loss in mice. Targeting translational control preserves cognitive function in Alzheimer's models, revealing mRNA translation as a promising therapeutic axis for memory preservation.
Felipe C. Ribeiro, Danielle Cozachenco, Michael Parkhill, Brandon Rodrigue, Caio Borges, Jean‐Claude Lacaille, Karim Nader, Fernanda G. De Felice, Mychael V. Lourenco, Argel Aguilar‐Valles, Nahum Sonenberg, Sergio T. Ferreira   +11 more
wiley   +1 more source

Lifelong Impact of Prenatal Stress: Exacerbated Memory Impairments and Gene Expression Changes Under Adult Chronic Stress. [PDF]

Brain Behav
Dogani M, Askari N, Vaez-Mahdavi MR.
europepmc   +1 more source