Results 11 to 20 of about 2,321,962 (333)
SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation. [PDF]
PLoS ONE, 2013 AMPA receptors-mediators of fast, excitatory transmission and synaptic plasticity in the brain-achieve great functional diversity through interaction with different auxiliary subunits, which alter both the trafficking and biophysical properties of these ...
Kathryn L Lovero +3 more
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Stargazin Modulation of AMPA Receptors [PDF]
Cell Reports, 2016 Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
Shaikh, Sana A. +7 more
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Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation. [PDF]
PLoS ONE, 2012 Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins.
Artur Semenov +4 more
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Slow excitatory synaptic currents generated by AMPA receptors [PDF]
, 2021 Decades of literature indicate that the AMPA‐type glutamate receptor is among the fastest acting of all neurotransmitter receptors. These receptors are located at excitatory synapses, and conventional wisdom says that they activate in hundreds of ...
Pampaloni, Niccolò P., Plested, Andrew
core +1 more source
Frontiers in Cellular Neuroscience, 2021 Synaptic and axonal glutamatergic signaling to NG2 glia in white matter is critical for the cells’ differentiation and activity dependent myelination. However, in gray matter the impact of neuron-to-NG2 glia signaling is still elusive, because most of ...
Stefan Hardt +6 more
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SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model [PDF]
Brazilian Journal of Medical and Biological Research, 2020 α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission.
Rong Li +5 more
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Nomadic AMPA Receptors and LTP [PDF]
Neuron, 1999 What are the broader implications of these two reports? One feature of LTP is its reversibility: once established, application of low-frequency stimulus train can decrease the synaptic strength. When applied to naive synapyses (i.e., in fresh brain slices), such low frequency stimulation induces a long-lasting depression of synaptic responses known as ...
Miguel Morales, Yukiko Goda
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eLife, 2022 At CA1→subiculum synapses, alternatively spliced neurexin-1 (Nrxn1SS4+) and neurexin-3 (Nrxn3SS4+) enhance NMDA-receptors and suppress AMPA-receptors, respectively, without affecting synapse formation.
Jinye Dai +3 more
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AMPA Receptors Bring On the Pain [PDF]
Neuron, 2004 The role of Ca(2+)-permeable AMPA receptors in pain processing has not been extensively studied. In this issue of Neuron, Hartmann et al. show that altering the levels of these receptors has consequences for inflammatory pain hypersensitivity but not acute pain processing.
Amy B. MacDermott, Carole Torsney
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Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca +4 more
wiley +1 more source