Reconsolidation has been considered a process in which a consolidated memory is turned into a labile stage. Within the reconsolidation window, the labile memory can be either erased or strengthened.
Boren Lin +9 more
doaj +1 more source
Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL [PDF]
The efficacy of excitatory transmission in the brain depends to a large extent on synaptic AMPA receptors, hence the importance of understanding the delivery and recycling of the receptors at the synaptic sites.
Dittgen, T. +11 more
core +1 more source
Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A. +4 more
core +1 more source
AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells
Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
doaj +1 more source
Interaction of GABA and Excitatory Amino Acids in the Basolateral Amygdala: Role in Cardiovascular Regulation [PDF]
Activation of the amygdala in rats produces cardiovascular changes that include increases in heart rate and arterial pressure as well as behavioral changes characteristic of emotional arousal.
Cook, Jennifer C. +3 more
core +2 more sources
p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA ...
Yuan Ge +10 more
doaj +1 more source
GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice
The GluA2 subunit in heteromeric AMPA receptor channels restricts Ca2+ permeability and block by polyamines, rendering linear the current-voltage relationship of these glutamate-gated cation channels.
Andrei eRozov +2 more
doaj +1 more source
Synapse elimination and learning rules co-regulated by MHC class I H2-Db. [PDF]
The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex (MHC)
Adelson, Jaimie +7 more
core +3 more sources
Background Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA receptors thus inducing Glu release from ...
Diego Currò +3 more
doaj +1 more source
Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA ...
Takahisa Hanada
doaj +1 more source

