Results 21 to 30 of about 45,095 (165)
Presynaptic AMPA Receptors in Health and Disease [PDF]
Cells, 2021 AMPA receptors (AMPARs) are ionotropic glutamate receptors that play a major role in excitatory neurotransmission. AMPARs are located at both presynaptic and postsynaptic plasma membranes. A huge number of studies investigated the role of postsynaptic AMPARs in the normal and abnormal functioning of the mammalian central nervous system (CNS).
Zanetti L. +4 more
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AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells
Frontiers in Cellular Neuroscience, 2019 Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
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Uncorking AMPA receptors [PDF]
Journal of General Physiology, 2017 New JGP study explains how auxiliary proteins relieve polyamine block of AMPARs.
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Gating Modes in AMPA Receptors [PDF]
The Journal of Neuroscience, 2010 AMPA receptors are ligand-gated ion channels that show multiple conductance levels, indicating that gating of individual AMPA subunits is to some extent independent of the other subunits. To study AMPAR subunit interactions during activation gating, we recorded from single channels in the absence of channel block and desensitization and at negative and
Lonnie P. Wollmuth, Martin Loynaz Prieto
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Resensitizing AMPA receptors [PDF]
Journal of General Physiology, 2019 JGP study suggests how the regulatory protein γ8 reopens AMPA receptor channels in the continued presence of glutamate.
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p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
Nature Communications, 2019 AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA ...
Yuan Ge +10 more
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GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice
Frontiers in Molecular Neuroscience, 2012 The GluA2 subunit in heteromeric AMPA receptor channels restricts Ca2+ permeability and block by polyamines, rendering linear the current-voltage relationship of these glutamate-gated cation channels.
Andrei eRozov +2 more
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AMPA Receptor Function in Hypothalamic Synapses [PDF]
Frontiers in Synaptic Neuroscience, 2022 AMPA receptors (AMPARs) are critical for mediating glutamatergic synaptic transmission and plasticity, thus playing a major role in the molecular machinery underlying cellular substrates of memory and learning. Their expression pattern, transport and regulatory mechanisms have been extensively studied in the hippocampus, but their functional properties
Royo, María +3 more
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Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum
Neuroscience, 2009 Heterogeneity among AMPA receptor (AMPAR) subtypes is thought to be one of the key postsynaptic factors giving rise to diversity in excitatory synaptic signaling in the CNS. Recently, compelling evidence has emerged that ancillary AMPAR subunits-the so-called transmembrane AMPA receptor regulatory proteins (TARPs)-also play a vital role in influencing ...
Ian D. Coombs, Stuart G. Cull-Candy
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The Journal of Headache and Pain, 2020 Background Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA receptors thus inducing Glu release from ...
Diego Currò +3 more
doaj +1 more source