Results 61 to 70 of about 2,321,962 (333)
Revising Berg-Purcell for finite receptor kinetics [PDF]
, 2021 From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv +1 more source
Journal of Biological Chemistry, 2015 Many molecular mechanisms underlie the changes in synaptic glutamate receptor content that are required by neuronal networks to generate cellular correlates of learning and memory.
M. Lussier, A. Sanz-Clemente, K. Roche
semanticscholar +1 more source
AMPA receptor biogenesis and trafficking
Current Opinion in Neurobiology, 2007 AMPA-type glutamate receptors mediate the majority of fast excitatory transmission in the central nervous system. The trafficking of AMPA receptors to and from synapses alters synaptic strength and has been recognized as a central mechanism underlying various forms of synaptic plasticity.
José A. Esteban, Ingo H. Greger
openaire +4 more sources
Development of AMPA Receptor Aptamers [PDF]
Biophysical Journal, 2010 The α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) subtype of glutamate ion channel receptors plays an essential role in the mammalian brain activities such as memory and learning, whereas the excessive receptor activation has been implicated in neurological diseases such as stroke, epilepsy, and amyotrophic lateral sclerosis.
Zhen Huang +5 more
openaire +2 more sources
Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons
Frontiers in Molecular Neuroscience, 2021 Different families of auxiliary subunits regulate the function and trafficking of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the central nervous system. While a facilitatory role of auxiliary subunits in ER export and
Ali Harb +7 more
doaj +1 more source
Journal of Neurochemistry, 2015 Subcellular trafficking of neuronal receptors is known to play a key role in synaptic development, homeostasis, and plasticity. We have developed a ligand‐targeted and photo‐cleavable probe for delivering a synthetic fluorophore to AMPA receptors ...
Rosamund E Combs-Bachmann +5 more
semanticscholar +1 more source
The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity
Frontiers in Cellular Neuroscience, 2014 In the mammalian central nervous system, excitatory glutamatergic synapses harness neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs).
T. Chater, Y. Goda
semanticscholar +1 more source
PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus
Nature Communications, 2021 Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance,
Pojeong Park +10 more
doaj +1 more source
Single NanoParticle Photothermal Tracking (SNaPT) of 5 nm gold beads in live cells [PDF]
Biophysical Journal 91, 12 (15/12/2006) 4598, 2007 Tracking individual nano-objets in live cells during arbitrary long times is an ubiquitous need in modern biology. We present here a method for tracking individual 5 nm gold nanoparticles on live cells. It relies on the photothermal effect and the detection of the Laser Induced Scattering around a NanoAbsorber (LISNA).
arxiv +1 more source
Critical postsynaptic density 95/disc large/zonula occludens-1 interactions by glutamate receptor 1 (GluR1) and GluR2 required at different subcellular sites [PDF]
, 2002 Interactions between AMPA receptor subunits and proteins containing postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domains have been shown to play critical roles in the proper trafficking of receptors to excitatory synapses.
Malinow, R., Piccini, A.
core +1 more source