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Angiotensin converting enzyme 2 (ACE2) - the major receptor for SARS-CoV-2 virus [PDF]

Farmacja Polska, 2021
The renin-angiotensin-aldosterone system (RAS) plays a significant role in the regulation of the water and electrolyte balance. Renin from the kidneys converts angiotensinogen to angiotensin I. Angiotensin converting enzyme (ACE) catalyzes the conversion
Sonia Frankowska, Karolina Zając, Klaudia Zargaryan, Jolanta Barbara Zawilska   +3 more
doaj   +1 more source

Decoding Angiotensin Receptors: TOMAHAQ‐Based Detection and Quantification of Angiotensin Type‐1 and Type‐2 Receptors

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The renin‐angiotensin system plays a crucial role in human physiology, and its main hormone, angiotensin, activates 2 G‐protein–coupled receptors, the angiotensin type‐1 and type‐2 receptors, in almost every organ.
Caglar Cosarderelioglu, Simion Kreimer, Alma I. Plaza‐Rodriguez, Pablo A. Iglesias, C. Conover Talbot, Helmy M. Siragy, Robert M. Carey, Ceereena Ubaida‐Mohien, Brian O'Rourke, Luigi Ferrucci, David A. Bennett, Jeremy Walston, Peter Abadir   +12 more
doaj   +1 more source

Angiotensin receptors and neuropathic pain

PAIN Reports, 2021
. Growing evidence implicates the renin–angiotensin system (RAS) in multiple facets of neuropathic pain (NP). This narrative review focuses primarily on the major bioactive RAS peptide, Angiotensin II (Ang II), and its receptors, namely type 1 (AT1R) and
Mihály Balogh, Clarissa Aguilar, Nicholas T. Nguyen, Andrew J. Shepherd   +3 more
doaj   +1 more source

Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain

Molecules, 2021
The current protocols for neuropathic pain management include µ-opioid receptor (MOR) analgesics alongside other drugs; however, there is debate on the effectiveness of opioids. Nevertheless, dose escalation is required to maintain their analgesia, which,
Kornél Király, Dávid Á. Karádi, Ferenc Zádor, Amir Mohammadzadeh, Anna Rita Galambos, Mihály Balogh, Pál Riba, Tamás Tábi, Zoltán S. Zádori, Éva Szökő, Susanna Fürst, Mahmoud Al-Khrasani   +11 more
doaj   +1 more source

Estrogen Metabolite 2-Methoxyestradiol Attenuates Blood Pressure in Hypertensive Rats by Downregulating Angiotensin Type 1 Receptor

Frontiers in Physiology, 2022
The therapeutic potential of 2-Methoxyestradiol (2ME2) is evident in cardiovascular disease. Our laboratory has previously demonstrated the mechanism involved in the 2ME2 regulation of angiotensin type 1 receptor (AT1R) in vitro. However, 2ME2 regulation
Yong Zhang, Benard O. Ogola, Laxmi Iyer, Vardan T. Karamyan, Thomas Thekkumkara   +4 more
doaj   +1 more source

Unveiling the Angiotensin-(1–7) Actions on the Urinary Bladder in Female Rats

Frontiers in Physiology, 2022
Angiotensin-(1–7) is a peptide produced by different pathways, and regardless of the route, the angiotensin-converting enzyme 2 (ACE-2) is involved in one of the steps of its synthesis.
Gustavo B. Lamy, Eduardo M. Cafarchio, Bárbara do Vale, Bruno B. Antonio, Daniel P. Venancio, Janaina S. de Souza, Rui M. Maciel, Gisele Giannocco, Gisele Giannocco, Artur F. Silva Neto, Lila M. Oyama, Patrik Aronsson, Monica A. Sato   +12 more
doaj   +1 more source

Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors

International Journal of Nephrology, 2022
The sympathetic and renin-angiotensin systems (RAS) are two critical regulatory systems in the kidney which affect renal hemodynamics and function. These two systems interact with each other so that angiotensin II (Ang II) has the presynaptic effect on ...
Hajaralsadat Hosseini-Dastgerdi, Fatemeh Kharazmi, Ali-Asghar Pourshanazari, Mehdi Nematbakhsh   +3 more
doaj   +1 more source

Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System

Molecules, 2022
Angiotensin receptor blockers (ARBs) used in the treatment of hypertension and potentially in SARS-CoV-2 infection exhibit inverse agonist effects at angiotensin AR1 receptors, suggesting the receptor may have evolved to accommodate naturally occurring ...
Graham J. Moore, Harry Ridgway, Konstantinos Kelaidonis, Christos T. Chasapis, Irene Ligielli, Thomas Mavromoustakos, Joanna Bojarska, John M. Matsoukas   +7 more
doaj   +1 more source

Potential use of angiotensin receptor blockers in skin pathologies [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Renin-angiotensin system (RAS) components such as angiotensin II, angiotensin receptors (AT1R and AT2R), and angiotensin-converting enzyme (ACE) are expressed in different cell types of the skin.
Keshvad Hedayatyanfard, Azadeh Khalili, Hosein Karim, Soren Nooraei, Ehsan Khosravi, Nazgol Sadat Haddadi, Ahmad Reza Dehpour, Gholamreza Bayat   +7 more
doaj   +1 more source

Angiotensin-Converting Enzyme Inhibitor / Angiotensin II Receptor Blocker in COVID-19: a Double-edged Sword or a Myth

Nepalese Medical Journal, 2020
Angiotensin-converting enzyme-2 receptor has been unearthed as a prime site of entry of Severe Acute Respiratory Syndrome Coronavirus 2 owing to its strong affinity towards spike protein of Severe Acute Respiratory Syndrome Coronavirus 2, resulting in ...
Kunal Bikram Shaha, Ashok Adhikari, Jung Rae Cho, Bimal Pandey, Yubaraj Sharma, Sajjad Safi   +5 more
doaj   +1 more source