Results 11 to 20 of about 97,708 (240)
Biomedicines, 2023 (1) Background: SARS-CoV-2 infection has been linked to diverse clinical manifestations in humans, including cardiovascular complications. Functional autoantibodies targeting G-protein-coupled receptors have emerged as potential contributors to these ...
Gerd Wallukat +4 more
doaj +1 more source
Olmesartan potentiates the anti-angiogenic effect of sorafenib in mice bearing Ehrlich's ascites carcinoma: role of angiotensin (1-7). [PDF]
PLoS ONE, 2014 Local renin-angiotensin systems exist in various malignant tumor tissues; this suggests that the main effector peptide, angiotensin II, could act as a key factor in tumor growth.
Mohammad M Abd-Alhaseeb +3 more
doaj +1 more source
Accurate Evaluation on the Interactions of SARS-CoV-2 with Its Receptor ACE2 and Antibodies CR3022/CB6 [PDF]
CHIN.PHYS.LETT. Vol.38, No.1(2021)018701 Express Letter, 2021 The spread of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a global health crisis. The binding affinity of SARS-CoV-2 (in particular the receptor binding domain, RBD) to its receptor angiotensin converting enzyme 2 (ACE2) and the antibodies is of great importance in ...
arxiv +1 more source
Role of the ACE2/Ang-(1-7)/Mas axis in glucose metabolism [PDF]
Reviews in Cardiovascular Medicine, 2021 The renin-angiotensin system (RAS) helps to regulate cardiovascular function, the maintenance of electrolyte and fluid balance, and blood pressure. The RAS contains two axes; the angiotensin-converting enzyme/angiotensin II/Ang II type 1 receptors ...
Shiyuan Zhao +2 more
doaj +1 more source
In-Silico evidence for two receptors based strategy of SARS-CoV-2 [PDF]
Front. Mol. Biosci., 09 June 2021, 2020 We propose a novel numerical method able to determine efficiently and effectively the relationship of complementarity between portions of proteins surfaces. This innovative and general procedure, based on the representation of the molecular iso-electron density surface in terms of 2D Zernike polynomials, allows the rapid and quantitative assessment of ...
arxiv +1 more source
G protein coupled receptors of the renin-angiotensin system: new targets against breast cancer?
Frontiers in Pharmacology, 2015 G-protein coupled receptors (GPCRs) constitute the largest family of membrane receptors, with high potential for drug discovery. These receptors can be activated by a panel of different ligands including ions, hormones, small molecules and vasoactive ...
Clara eNAHMIAS +1 more
doaj +1 more source
Brazilian Archives of Biology and Technology, 2012 The success of revascularization procedures is limited by recurrent stenosis, which is a narrowing of a blood vessels that results from neo-intimal hyperplasia.
Natália Tambelline +6 more
doaj +1 more source
Current status of liver transplantation for non‐B non‐C liver cirrhosis and hepatocellular carcinoma
Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 42-52, January 2023., 2023 Recently, the cases of LT for non‐B non‐C cirrhosis and HCC have been increasing in Japan as well as worldwide. Perioperative management of non‐B non‐C liver disease is problematic due to various risk factors, including alcohol consumption and metabolic syndrome‐related risks, such as obesity and diabetes mellitus.
Takahiro Nishio +4 more
wiley +1 more source
The hyperglycemia induced by angiotensin II in rats is mediated by AT1 receptors
Brazilian Journal of Medical and Biological Research, 1998 We have shown that the renin-angiotensin system (RAS) is involved in glucose homeostasis during acute hemorrhage. Since almost all of the physiological actions described for angiotensin II were mediated by AT1 receptors, the present experiments were ...
L.J.C. Machado +3 more
doaj +1 more source
Tetracycline as an inhibitor to the coronavirus SARS-CoV-2 [PDF]
J Cell Biochem (2021) 1-8, 2020 The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address the role of Tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.
arxiv +1 more source