Results 11 to 20 of about 104,105 (242)

Localization and Expression of Renin–Angiotensin System Receptors in Lung from Transplant Patients: A Case-Control Study [PDF]

Biomedicines
Objective: We aimed to assess the expression and localization of renin-angiotensin system (RAS) receptors in lung tissue and the plasma concentration of related peptides in IPF patients. Materials and Methods: This case–control study involved 19 patients
Andresa Thomé Silveira, Lucas Sagrillo Fagundes, Juliane Flor, Isabel Amaral Martins, Laura Bastos Otero, Laura Tibola Marques da Silva, Lorenzo Santana Maciel, Sarah Eller, Giuliano Rizzotto Guimarães, Fabíola Adelia Perin, Márcia Rosângela Wink, Katya Rigatto   +11 more
doaj   +2 more sources

Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System

Molecules, 2022
Angiotensin receptor blockers (ARBs) used in the treatment of hypertension and potentially in SARS-CoV-2 infection exhibit inverse agonist effects at angiotensin AR1 receptors, suggesting the receptor may have evolved to accommodate naturally occurring ...
Graham J. Moore, Harry Ridgway, Konstantinos Kelaidonis, Christos T. Chasapis, Irene Ligielli, Thomas Mavromoustakos, Joanna Bojarska, John M. Matsoukas   +7 more
doaj   +1 more source

Animals Experimentally Infected with SARS-CoV-2 Generate Functional Autoantibodies against G-Protein-Coupled Receptors

Biomedicines, 2023
(1) Background: SARS-CoV-2 infection has been linked to diverse clinical manifestations in humans, including cardiovascular complications. Functional autoantibodies targeting G-protein-coupled receptors have emerged as potential contributors to these ...
Gerd Wallukat, Kerstin Wernike, Dipthi Bachamanda Somesh, Thomas C. Mettenleiter, Johannes Müller   +4 more
doaj   +1 more source

Olmesartan potentiates the anti-angiogenic effect of sorafenib in mice bearing Ehrlich's ascites carcinoma: role of angiotensin (1-7). [PDF]

PLoS ONE, 2014
Local renin-angiotensin systems exist in various malignant tumor tissues; this suggests that the main effector peptide, angiotensin II, could act as a key factor in tumor growth.
Mohammad M Abd-Alhaseeb, Sawsan A Zaitone, Soad H Abou-El-Ela, Yasser M Moustafa   +3 more
doaj   +1 more source

Role of the ACE2/Ang-(1-7)/Mas axis in glucose metabolism [PDF]

Reviews in Cardiovascular Medicine, 2021
The renin-angiotensin system (RAS) helps to regulate cardiovascular function, the maintenance of electrolyte and fluid balance, and blood pressure. The RAS contains two axes; the angiotensin-converting enzyme/angiotensin II/Ang II type 1 receptors ...
Shiyuan Zhao, Wenxue Sun, Pei Jiang   +2 more
doaj   +1 more source

G protein coupled receptors of the renin-angiotensin system: new targets against breast cancer?

Frontiers in Pharmacology, 2015
G-protein coupled receptors (GPCRs) constitute the largest family of membrane receptors, with high potential for drug discovery. These receptors can be activated by a panel of different ligands including ions, hormones, small molecules and vasoactive ...
Clara eNAHMIAS, Sylvie eRODRIGUES-FERREIRA   +1 more
doaj   +1 more source

The effect of losartan on angiotensin II-induced cell proliferation in a rat aorta smooth muscle cell line

Brazilian Archives of Biology and Technology, 2012
The success of revascularization procedures is limited by recurrent stenosis, which is a narrowing of a blood vessels that results from neo-intimal hyperplasia.
Natália Tambelline, Karen Oliveira, Luiz Renato Olchanheski Junior, Regina Sordi, Michel Fleith Otuki, Giovani Marino Favero, Daniel Fernandes   +6 more
doaj   +1 more source

The hyperglycemia induced by angiotensin II in rats is mediated by AT1 receptors

Brazilian Journal of Medical and Biological Research, 1998
We have shown that the renin-angiotensin system (RAS) is involved in glucose homeostasis during acute hemorrhage. Since almost all of the physiological actions described for angiotensin II were mediated by AT1 receptors, the present experiments were ...
L.J.C. Machado, U. Marubayashi, A.M. Reis, C.C. Coimbra   +3 more
doaj   +1 more source

Differential mechanisms of activation of the Ang peptide receptors AT1, AT2, and MAS: using in silico techniques to differentiate the three receptors.

PLoS ONE, 2013
The renin-angiotensin system is involved in multiple conditions ranging from cardiovascular disorders to cancer. Components of the pathway, including ACE, renin and angiotensin receptors are targets for disease treatment.
Jeremy W Prokop, Robson A S Santos, Amy Milsted   +2 more
doaj   +1 more source

Angiotensin peptides in the regulation of adrenal cortical function

Exploration of Medicine, 2021
The adrenal cortex plays a key role in the regulation of metabolism, salt and water homeostasis and sex differentiation by synthesizing glucocorticoid, mineralocorticoid and androgen hormones.
Gian Paolo Rossi, Livia Lenzini, Brasilina Caroccia, Giacomo Rossitto, Teresa Maria Seccia   +4 more
doaj   +1 more source