Increased angiotensin II receptor binding with age in isolated rat glomeruli [PDF]
, 1988 Increased angiotensin II receptor binding with age in isolated rat glomeruli. The current investigation was performed to determine whether there are changes in the renin-angiotensin system with increasing age in rats.
Silverman, Sabrina, Wilkes, Barry M.
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Clinical and Experimental Hypertension, 2017 Hypertension and diabetes are multifactorial diseases that frequently coexist and exacerbate each another. During the development of diabetes, the impairment of noradrenergic and renin-angiotensin systems has been reported in the response mediated by α1 ...
Jessica Edith Rodríguez +6 more
doaj +1 more source
Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key?
Frontiers in Immunology, 2020 To date the pathophysiology of COVID-19 remains unclear: this represents a factor determining the current lack of effective treatments. In this paper, we hypothesized a complex host response to SARS-CoV-2, with the Contact System (CS) playing a pivotal ...
Simone Meini +6 more
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What’s new in the renin-angiotensin system?
Cellular and Molecular Life Sciences (CMLS), 2004 .Cellular entry of enveloped viruses is often dependent on attachment proteins expressed on the host cell surface. Viral envelope proteins bind these receptors, and, in an incompletely understood process, facilitate fusion of the cellular and viral ...
Wenhui Li +11 more
semanticscholar +1 more source
The multifaceted roles of PI3Kγ in hypertension, vascular biology, and inflammation [PDF]
, 2016 PI3Kγ is a multifaceted protein, crucially involved in cardiovascular and immune systems. Several studies described the biological and physiological functions of this enzyme in the regulation of cardiovascular system, while others stressed its role in ...
Carnevale, Daniela +2 more
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A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI [PDF]
, 2013 BACKGROUND: Acute kidney injury (AKI) is a frequent condition in hospitalised patients undergoing major surgery or the critically ill and is associated with increased mortality.
Delles, C. +6 more
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Angiotensin Type 2 Receptors: Painful, or Not?
Frontiers in Pharmacology, 2020 Pain in response to various types of acute injury can be a protective stimulus to prevent the organism from using the injured part and allow tissue repair and healing. On the other hand, neuropathic pain, defined as ‘pain caused by a lesion or disease of
Lakshmi Pulakat +2 more
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Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses [PDF]
Pharmacol Res, 136:108-20 (2018), 2019 Angiotensin II (AngII) type 1 receptor (AT1R) is a G protein-coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases. Its functions are mediated through G protein dependent and independent signaling pathways. AT1R has several endogenous peptidic agonists, all derived from angiotensinogen, as
arxiv +1 more source
The renin-angiotensin system: going beyond the classical paradigms
American Journal of Physiology. Heart and Circulatory Physiology, 2019 Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the discovery of angiotensin-(1−7) [ANG-(1−7)] generation in vivo. Later, angiotensin-converting enzyme 2 (ACE2) was shown to be the main mediator of this reaction, and ...
R. Santos +5 more
semanticscholar +1 more source
Angiotensin type-2 (AT-2)-receptor activation reduces renal fibrosis in cyclosporine nephropathy: evidence for blood-pressure independent effect [PDF]
, 2016 Compound 21 (C21), selective agonist of AT2 receptors, shows antinflammatory effects in hypertension and nephroprotection in diabetes. The aim of this study was to evaluate the effects of C21 in cyclosporine nephropathy, which is characterized mainly by ...
Carletti, R +5 more
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