Results 41 to 50 of about 97,708 (240)

Featuring ACE2 binding SARS-CoV and SARS-CoV-2 through a conserved evolutionary pattern of amino acid residues [PDF]

arXiv, 2020
Spike (S) glycoproteins mediate the coronavirus entry into the host cell. The S1 subunit of S-proteins contains the receptor-binding domain (RBD) that is able to recognize different host receptors, highlighting its remarkable capacity to adapt to their hosts along the viral evolution.
arxiv  

In silico ADMET and molecular docking study on searching potential inhibitors from limonoids and triterpenoids for COVID-19 [PDF]

, 2020
Virtual screening of phytochemicals was performed through molecular docking, simulation, in silico ADMET and drug-likeness prediction to identify the potential hits that can inhibit the effects of SARS-CoV-2. Considering the published literature on medicinal importance, total 154 phytochemicals with analogous structure from limonoids and triterpenoids ...
arxiv   +1 more source

Self‐Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound

Advanced Healthcare Materials, EarlyView.
High glucose‐ and acid‐responsive hydrogel with dynamic covalent bond solubilized with flavonoids (Gel‐Flavonoids) is designed for diabetic wound healing. The Gel‐Flavonoids adapt to irregular wound shapes and release antioxidants in high‐glucose environments, effectively reducing reactive oxygen species.
Qiang Zeng, Sa Du, Rui Yuan, Yuan Zeng, Xuefen Li, Yu‐Wei Wu, Ke Chen, Lei Tao, Zhihui Tang, Xuliang Deng   +9 more
wiley   +1 more source

The Role of Angiotensin II and Cyclic AMP in Alveolar Active Sodium Transport. [PDF]

PLoS ONE, 2015
Active alveolar fluid clearance is important in keeping airspaces free of edema. Angiotensin II plays a role in the pathogenesis of hypertension, heart failure and others.
Reem Ismael-Badarneh, Julia Guetta, Geula Klorin, Gidon Berger, Niroz Abu-Saleh, Zaid Abassi, Zaher S Azzam   +6 more
doaj   +1 more source

Mathematical model of SARS-Cov-2 propagation versus ACE2 fits COVID-19 lethality across age and sex and predicts that of SARS, supporting possible therapy [PDF]

arXiv, 2020
The fatality rate of Covid-19 escalates with age and is larger in men than women. I show that these variations correlate strongly with the level of the viral receptor protein ACE2 in rat lungs, which is consistent with the still limited and apparently contradictory data on human ACE2.
arxiv  

Functional Polymer Nanocomposites by Gas Aggregation Cluster Source and Initiated Chemical Vapor Deposition

Advanced Materials Technologies, EarlyView.
In this work, a gas aggregation cluster source and an initiated chemical vapor deposition are combined in a single vacuum reactor. With this setup polymer thin films can be combined with functional nanoparticles. As a proof‐of‐concept PTFE is combined with silver nanoparticles and tested in antibacterial, antiviral, and anticancer applications ...
Torge Hartig, Joschka Paulsen, Jonas Drewes, Asmaa T. Mohamed, Nasra F. Abdel Fattah, Cedric Hinrichs, Felix Pohl, Stefan Rehders, Ainura Aliyeva, Henning Wieker, Jörg Wiltfang, Salih Veziroglu, Samah A Loutfy, Oral Cenk Aktas, Alexander Vahl, Thomas Strunskus, Aydin Gülses, Amal Amin, Stefan Schröder, Franz Faupel   +19 more
wiley   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

Advanced Science, EarlyView.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran, Yideul Jeong, Suwoo Kim, Ji Eun Yeom, Jinwoo Lee, Wonhwa Lee, Gyu‐Un Bae, Jong‐Sun Kang   +7 more
wiley   +1 more source

Endothelial Vasodilator Angiotensin Receptors are Changing in Mice with Ageing

Research in Molecular Medicine, 2014
Background: The vascular function of Angiotensin II-type-2 receptors in adults is controversial. We sought their location and function in mouse aortic rings at young and old mice.
Majid Malekzadeh Shafaroudi, Craig J Dlay   +1 more
doaj