Results 161 to 170 of about 1,004,480 (189)
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Compartmentalization of B-cell antigen receptor functions
Molecular Immunology, 1996Receptor tyrosine kinases (RTK), like the PDGF-receptor, translate information from the extracellular environment into cytoplasmic signals that regulate a spectrum of cellular functions. RTK molecules consist of ligand binding extracellular domains, cytoplasmic kinase domains and tyrosine phosphorylation sites [Ullrich and Schlessinger, 1990 (Cell 61 ...
Lankester, A. C., van Lier, R. A.
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B Cell Receptor and Antigens in CLL
2013Nowadays, chronic lymphocytic leukemia (CLL) is considered as a prototypic antigen-driven lymphoma, with antigenic stimuli from the microenvironment promoting tumor outgrowth. Antigen recognition is a function of both the clonotypic B cell receptor immunoglobulin (BcR IG) and various other immune sensors, e.g., the Toll-like receptors.
Andreas, Agathangelidis +2 more
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B-cell development and antigen receptor signalling
Biochemical Society Transactions, 2002B-cell development and function requires the products of the Vav family of genes. Vav proteins act as key components of the antigen receptor signal transduction machinery by integration of signals that control the cell cycle, differentiation and apoptosis.
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Signal Transduction by the B‐Cell Antigen Receptor
Annals of the New York Academy of Sciences, 1995The antigen receptor of B lymphocytes (BCR) plays important roles in recognition of foreign antigens and self-components to allow the immune system to make appropriate antibody responses. The BCR is a complex between membrane immunoglobulin and the Ig-alpha and Ig-beta heterodimer.
ANTHONY L. DEFRANCO +10 more
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Molecular Mechanisms of B Cell Antigen Receptor Trafficking
Annals of the New York Academy of Sciences, 2003Abstract: B lymphocytes are among the most efficient cells of the immune system in capturing, processing, and presenting MHC class II restricted peptides to T cells. Antigen capture is essentially restricted by the specificity of the clonotypic antigen receptor expressed on each B lymphocyte.
Marcus R, Clark +3 more
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Stability of the B cell antigen receptor complex
Molecular Immunology, 2000The B cell antigen receptor (BCR) comprises the membrane-bound immunoglobulin (mIg) molecule and the Ig-alpha/Ig-beta heterodimer. By comparing the stability of the IgD-BCR and IgM-BCR in different detergent lysates, we find that the IgD-BCR is more stable than the IgM-BCR.
W W, Schamel, M, Reth
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Antigen Receptor Function in Chronic Lymphocytic Leukemia B Cells
Leukemia & Lymphoma, 1996Functional studies revealed that two groups of B chronic lymphocytic leukemia (B-CLL) can be distinguished based on their capacity to mount a proliferative response following B-cell antigen receptor (BCR) cross-linking. The molecular basis for the functional distinction between these B-CLL groups most probably resides within or proximal to the BCR ...
Lankester, A. C. +4 more
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Transmembrane signalling by the B-cell antigen receptor
Current Opinion in Immunology, 1994Crosslinking the B-cell antigen receptor is sufficient to generate intracellular signals. Recent work has shown that this signalling capability can be ascribed to the presence of the alpha and beta sheath proteins within the antigen receptor that couple it to signal transduction pathways.
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Journal of Allergy and Clinical Immunology, 1999
Functional differentiation of B lymphocytes can be regulated at different levels. Such B-cell responses, to a large extent, are under the control of T cells and the release of soluble factors from these cells. Crosslinking of B-cell antigen receptors also can direct B-cell differentiation, although the mechanisms are not well defined and the effects on
A, Oshiba, E W, Gelfand
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Functional differentiation of B lymphocytes can be regulated at different levels. Such B-cell responses, to a large extent, are under the control of T cells and the release of soluble factors from these cells. Crosslinking of B-cell antigen receptors also can direct B-cell differentiation, although the mechanisms are not well defined and the effects on
A, Oshiba, E W, Gelfand
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Signal transduction from the B cell antigen-receptor
Current Opinion in Immunology, 1999Ligation of the B cell antigen-receptor triggers an intricate maze of intercalated biochemical events that ultimately affect B cell biological responses. Recent advances have helped to connect many loose ends by identifying key adaptor proteins, such as BLNK/SLP-65, defining crucial roles for phosphatidylinositol-3-kinase and mapping pathways ...
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