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2010
1 Structure and Synthesis of the BCR 2 BCR Signaling 3 BCR Antigen Uptake Function 4 Functions of the BCR in B-Cell Maturation and Activation 5 Conclusion Keywords: B-cell antigen receptor (BCR); BCR signaling; B lymphocytes and making antibodies; pre-BCR and B-cell development; protein tyrosine kinase activation by BCR;
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1 Structure and Synthesis of the BCR 2 BCR Signaling 3 BCR Antigen Uptake Function 4 Functions of the BCR in B-Cell Maturation and Activation 5 Conclusion Keywords: B-cell antigen receptor (BCR); BCR signaling; B lymphocytes and making antibodies; pre-BCR and B-cell development; protein tyrosine kinase activation by BCR;
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Molecular mechanisms in B cell antigen receptor signaling
Current Opinion in Immunology, 1997Recent gene-targeting experiments have highlighted the importance of the intracellular protein tyrosine kinases Lyn, Syk, and Btk in BCR signal transduction and B cell development. In addition, the interactions of these kinases and their regulatory mechanisms have been reported.
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GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING
Annual Review of Immunology, 1999▪ Abstract In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development.
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Compartmentalization and B cell antigen receptor signaling
2005This thesis focuses on two aspects of compartmentalization with respect to BCR signaling. In the first section, compartmentalization of the BCR to lipid rafts is considered and in the second section the subsequent compartmentalization of BLNK and PLCy to the BCR is considered.
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Signalling Function of the B‐Cell Antigen Receptors
Immunological Reviews, 1993K M, Kim, G, Alber, P, Weiser, M, Reth
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Developmental Maturation of the B‐Cell Antigen Receptor
Immunological Reviews, 1993J, Jongstra, V, Misener
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