Results 11 to 20 of about 26,522 (128)

Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus. [PDF]

Proceedings of the National Academy of Sciences, 1990
Two gamma delta T-cell subsets that are generated in the fetal thymus and selectively localize in epidermis and uterus-vagina-tongue epithelia exhibit remarkable homogeneity in their (T-cell) antigen receptors (TCR). In the present study, we show that cells expressing the canonical gamma delta TCR are also generated in fetal thymus organ cultures ...
S, Itohara, S, Tonegawa
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A novel SARS-CoV-2 Beta RBD DNA vaccine directly targeted to antigen-presenting cells induces strong humoral and T cell responses

Scientific Reports, 2023
Throughout the COVID-19 pandemic, several variants of concern (VoC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have evolved, affecting the efficacy of the approved COVID-19 vaccines.
Katarzyna Kuczkowska, Louise Bjerkan, Elisabeth Stubsrud, Hannah Cuthbertson Husbyn, Stalin Chellappa, Anette Hauge, Renate Skarshaug, Maria Lyngaas Torgersen, Joel Benjamin Heim, Marthe Jøntvedt Jørgensen, Christian Winther Wold, Mariane Høgsbjerg Schleimann, Martin Tolstrup, Stine Granum, Agnete Brunsvik Fredriksen, Mikkel Wandahl Pedersen, Gunnstein Norheim   +16 more
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Apoptosis Induced via Gamma Delta T Cell Antigen Receptor “Blocking” Antibodies: A Cautionary Tale [PDF]

Frontiers in Immunology, 2017
Mechanistic studies contribute greatly to our understanding of γδ T cell (γδTc) biology, aiding development of these cells as immunotherapeutic agents. The antibody blocking assay is an accepted method to determine the receptors involved in γδTc killing of tumor targets.
Dutta, Indrani, Postovit, Lynne-Marie, Siegers, Gabrielle M.   +2 more
openaire   +3 more sources

Clinical applications of gamma delta T cells with multivalent immunity

Frontiers in Immunology, 2014
Gamma delta T cells hold promise for adoptive immunotherapy because of their reactivity to bacteria, viruses, and tumors. However, these cells represent a small fraction (1-5%) of the peripheral T-cell pool and require activation and propagation to ...
Drew C Deniger, Judy S Moyes, Laurence JN Cooper   +2 more
doaj   +1 more source

Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta. [PDF]

Proceedings of the National Academy of Sciences, 1991
The kinetics of postnatal intestinal colonization by T cells carrying gamma delta and alpha beta T-cell antigen receptors were studied in nude and normal mice by flow cytometry and immunohistology. Furthermore, gamma delta and alpha beta T-cell development was analyzed in lethally irradiated mice that were reconstituted by fetal liver precursors with ...
A, Bandeira, S, Itohara, M, Bonneville, O, Burlen-Defranoux, T, Mota-Santos, A, Coutinho, S, Tonegawa   +6 more
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Mixing signals: Molecular turn ons and turn offs for innate γδ Τ cells

Frontiers in Immunology, 2014
Lymphocytes of the gamma delta (γδ) T cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors a large proportion respond as innate effectors. γδ T cells are poised to combat infection by responding rapidly
Vasileios eBekiaris, Vasileios eBekiaris, John S Šedý, Carl F Ware   +3 more
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Chimeric Antigen Receptor T-Cells for the Treatment of Gamma-Delta T-Cell Malignancies

Blood, 2018
Abstract Introduction Cancers derived from the malignant transformation of gamma delta T-cells are rare but carry very poor prognosis. Hepatosplenic T-cell lymphoma is a highly aggressive condition characterised by hepatosplenic and bone marrow involvement.
Paul Maciocia, Patrycja Wawrzyniecka, Leo Kassimatis, Martin Pule   +3 more
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Disulfide-linked gamma delta T cell antigen receptors expressed on T cells derived from patients with primary immunodeficiency disorders. [PDF]

Journal of Clinical Investigation, 1989
T cell lines or clones from two patients, one with a partial DiGeorge syndrome and one with severe common variable immunodeficiency expressed disulfide-linked gamma delta T cell antigen receptor (TCR) comprised of a gamma-chain polypeptide of 40-43 kD, and a delta-chain polypeptide of 37-40 kD.
H, Seki, M, Nanno, N K, Day, R A, Good, C D, Platsoucas   +4 more
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Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia. [PDF]

The Journal of experimental medicine, 1994
zeta and eta chains of the T cell antigen receptor (TCR) complex and the gamma chain of Fc receptors (FcR gamma) constitute a family of proteins important for the expression of, and signal transduction through, these receptors in hematopoietic cells. In zeta-deficient mice, TCR expression was reduced in most T cells.
H, Ohno, S, Ono, N, Hirayama, S, Shimada, T, Saito   +4 more
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The Vγ9Vδ2 T cell antigen receptor and butyrophilin 3 A1 (BTN3A1): Models of interaction, the possibility of co-evolution, and the case of dendritic epidermal T cells

Frontiers in Immunology, 2014
Most circulating human gamma delta T cells are Vγ9Vδ2 T cells. Their hallmark is the expression of T cell antigen receptors (TCR) whose γ-chains show a Vγ9-JP (Vγ2-Jγ1.2) rearrangement and are paired with Vδ2 containing δ-chains, a dominant TCR ...
Mohindar Murugesh eKarunakaran, Thomas eHerrmann   +1 more
doaj   +1 more source