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Fifty Years of Natural Killer Cells: Milestones and Future Horizons. [PDF]

open access: yesScand J Immunol
Lundqvist A   +7 more
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Antigen-specific T cell receptors

1987
Publisher Summary This chapter discusses immunoglobulin-related T cell receptors. It also presents the production of antibodies to both antigen-binding T cell receptors that are known to be related to immunoglobulin variable regions and to the α/β heterodimers that do not bind antigen, but are encoded by rearranged genes showing sufficient homology ...
J J, Marchalonis, S F, Schluter
openaire   +2 more sources

T cell antigen receptor signal transduction

Current Opinion in Cell Biology, 1997
The T cell antigen receptor (TCR) initiates signal transduction by activating multiple cytoplasmic protein tyrosine kinases (PTKs). Considerable progress in the field of TCR signal transduction has been made in three areas recently: first, in understanding the structure and function of the PTK ZAP-70; second, in the elucidation of the function of the ...
D, Qian, A, Weiss
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T cell antigen receptor antibodies

Nature, 1987
Immunology has a long tradition of using the immune system to study the immune system. Monoclonal antibodies are now being focused upon the antigen receptor of the T lymphocyte.
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T cell antigen-receptor signal transduction

Current Opinion in Immunology, 1999
During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-Cgamma1-Ca2+ signalling pathways.
J E, van Leeuwen, L E, Samelson
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The gamma T-cell antigen receptor

Journal of Clinical Immunology, 1987
The gamma-TCR is encoded by genes composed of V, J, and C elements that demonstrate a limited potential for recombinational diversity. These genes are rearranged, transcribed, and translated into proteins early during thymic ontogeny. Lymphocytes express gamma-TCR proteins on the plasma membrane only in association with the CD3 complex.
L L, Lanier   +7 more
openaire   +2 more sources

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