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Chimeric antigen receptor T-cell toxicity
Current Opinion in Pediatrics, 2019Purpose of review Chimeric antigen receptor -(CAR) T-cell therapy has become a commonly used immunotherapy originally used in the treatment of B-cell leukemias but which are now applied broadly across tumor classes. Although high rates of remission are associated with CAR T-cell therapy, toxicities associated with these novel ...
DaMarcus E, Baymon, Edward W, Boyer
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Chimeric antigen receptor T cells march into T cell malignancies
Journal of Cancer Research and Clinical Oncology, 2023T cell malignancies represent a diverse collection of leukemia/lymphoma conditions in humans arising from aberrant T cells. Such malignancies are often associated with poor clinical prognoses, cancer relapse, as well as progressive resistance to anti-cancer treatments.
Jie, Tang, Xudong, Zhao
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Chimeric antigen receptor T‐cell therapy toxicities
British Journal of Clinical Pharmacology, 2020Cancer immunotherapy has greatly advanced in recent years, with chimeric antigen receptor (CAR) T cells emerging as an innovative technology that harnesses the immune system to fight malignant diseases. These genetically engineered T‐cells have shown encouraging results for B‐cell lymphoid malignancies and are now being explored for other cancer types.
Uri Greenbaum +7 more
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Grouping T-Cell Antigen Receptors by Specificity
2022Grouping TCRs on the similarity of CDR3 sequences could effectively cluster them by specificity. Three versions of the GLIPH algorithm are described briefly here, with instructions to use GLIPH algorithms to cluster TCRs by specificity.
Chunlin, Wang +2 more
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Advances in chimeric antigen receptor T cells
Current Opinion in Hematology, 2020Purpose of review To discuss the important advances in CAR T cell therapy over the past year, focusing on clinical results where available. Recent findings Approximately 30 years after they were first conceived of and 15 years after the first small-scale single-center clinical ...
Ofrat, Beyar-Katz, Saar, Gill
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Soluble T-cell products antigenically related to T-cell receptors
Cytokine, 1995Human peripheral blood mononuclear cells (PBMC) cultured with or without concanavalin A (Con A) secrete soluble TCR alpha and TCR beta chains. Soluble TCR-like products of three different relative molecular masses--185,000 (Mr 185 kDa), 152 and 42 kDa--which are antigenically similar to those on T lymphocytes have been found in sera from healthy adult ...
S, Ishizaka, T, Tsujii
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T-cell antigen receptors in rheumatoid arthritis
Immunologic Research, 1994Rheumatoid arthritis (RA) is a systemic disease of unknown etiology characterized by chronic inflammation mainly in the joints. Several lines of evidence suggest that T cells are involved in the pathogenesis of the disease. RA is associated with certain HLA-DR alleles.
L I, Sakkas, P F, Chen, C D, Platsoucas
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1996
Abstract The characteristics of T cell recognition and the nature of their antigen receptors has long been a difficult and controversial area for immunologists. However, the development of cloned T cell lines and hybrids (as reviewed in ref.
Mark M Davis, Yueh-Hsiu Chien
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Abstract The characteristics of T cell recognition and the nature of their antigen receptors has long been a difficult and controversial area for immunologists. However, the development of cloned T cell lines and hybrids (as reviewed in ref.
Mark M Davis, Yueh-Hsiu Chien
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Anticancer research, 1983
T cells play an important role in regulating the immune response to virtually all antigens. Central to the functioning of these lymphocytes is their capacity to recognize and respond to antigen. Although the T cell receptor has yet to be defined in precise terms, considerable information has accrued concerning its structure and function.
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T cells play an important role in regulating the immune response to virtually all antigens. Central to the functioning of these lymphocytes is their capacity to recognize and respond to antigen. Although the T cell receptor has yet to be defined in precise terms, considerable information has accrued concerning its structure and function.
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