Results 21 to 30 of about 929,693 (286)
Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production [PDF]
, 2016 Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigenbinding lymphocytes in different contexts.
Domaschenz, Heather +8 more
core +1 more source
EBioMedicine, 2016 Dendritic cells (DCs) are major antigen-presenting cells that can efficiently prime and cross-prime antigen-specific T cells. Delivering antigen to DCs via surface receptors is thus an appealing strategy to evoke cellular immunity.
Wenjie Yin +15 more
doaj +1 more source
Discovering immunoreceptor coupling and organization motifs
Frontiers in Immunology, 2023 The recently determined cryo-EM structures of the T cell antigen receptor (TCR) and B cell antigen receptor (BCR) show in molecular details the interactions of the ligand-binding part with the signaling subunits but they do not reveal the signaling ...
Michael Reth, Michael Reth
doaj +1 more source
T-cell antigen receptor genes and T-cell recognition [PDF]
Nature, 1988 The four distinct T-cell antigen receptor polypeptides (alpha, beta, gamma, delta) form two different heterodimers (alpha:beta and gamma:delta) that are very similar to immunoglobulins in primary sequence, gene organization and modes of rearrangement.
M M, Davis, P J, Bjorkman
openaire +2 more sources
CAR-T Cells: Precision Cancer Immunotherapy
Indonesian Biomedical Journal, 2018 BACKGROUND: Current cancer drugs and treatments are aiming at eradicating tumor cells, but often are more toxic then effective, killing also the normal cells and not selectively the tumor cells.
Anna Meiliana +2 more
doaj +1 more source
Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation. [PDF]
PLoS ONE, 2008 B-cells integrate antigen-specific signals transduced via the B-cell receptor (BCR) and antigen non-specific co-stimulatory signals provided by cytokines and CD40 ligation in order to produce IgG antibodies.
Francisco J Quintana +3 more
doaj +1 more source
Targeting antigens to dendritic cell receptors for vaccine development [PDF]
, 2013 Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system which play a key role in regulating immune responses. Depending on the method of antigen delivery, DCs stimulate immune responses or induce tolerance.
Apostolopoulos, Vasso +3 more
core +2 more sources
Specificity, Privacy, and Degeneracy in the CD4 T Cell Receptor Repertoire Following Immunization. [PDF]
, 2017 T cells recognize antigen using a large and diverse set of antigen-specific receptors created by a complex process of imprecise somatic cell gene rearrangements.
Best, K +8 more
core +1 more source
The Role of FcRn in Antigen Presentation [PDF]
, 2014 Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the variety of signaling receptors to
Kristi eBaker +4 more
core +3 more sources
Chimeric antigen receptor T-cell therapy.
Australian prescriber, 2023 Chimeric antigen receptor T-cell therapies are promising new options for patients with relapsed or refractory diffuse large B-cell lymphoma or acute lymphoblastic leukaemia. They increase complete response rates and the chances of achieving prolonged remission.
Burge, Cale +2 more
openaire +2 more sources