Results 21 to 30 of about 836,416 (221)

On the Structure of the T-cell Receptor for Antigen

Cold Spring Harbor Symposia on Quantitative Biology, 1977
Antigen-binding receptors of T lymphocytes were analyzed in two different ways. First, the idiotypic properties of T helper cells are studied using anti-idiotypic antisera prepared against isolated antibodies specific for A-CHO. These anti-idiotypic antisera are defined by immunogenetic and immunochemical means with respect to their reactivity with ...
Günter J. Hämmerling, Ulrich Krawinkel, Matthias Cramer, C. Berek, K. Eichmann, Klaus Rajewsky, Samuel J. Black   +6 more
openaire   +2 more sources

The second touch hypothesis: T cell activation, homing and polarization [v2; ref status: indexed, http://f1000r.es/3zq]

F1000Research, 2014
The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj   +1 more source

Making Better Chimeric Antigen Receptors for Adoptive T-cell Therapy

Clinical Cancer Research, 2016
Chimeric antigen receptors (CAR) are engineered fusion proteins constructed from antigen recognition, signaling, and costimulatory domains that can be expressed in cytotoxic T cells with the purpose of reprograming the T cells to specifically target ...
M. Maus, C. June
semanticscholar   +1 more source

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen.

Blood, 2009
Gene therapy of human cancer using genetically engineered lymphocytes is dependent on the identification of highly reactive T-cell receptors (TCRs) with antitumor activity.
L. Johnson, R. Morgan, M. Dudley, L. Cassard, J. Yang, M. Hughes, U. Kammula, R. Royal, R. Sherry, J. Wunderlich, C. Lee, N. Restifo, S. Schwarz, Alexandria P. Cogdill, R. Bishop, Hung Kim, C. Brewer, Susan F. Rudy, C. Vanwaes, Jeremy L. Davis, A. Mathur, R. Ripley, Debbie-Ann N. Nathan, C. Laurencot, S. Rosenberg   +24 more
semanticscholar   +1 more source

Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8+ and CD4+ T Cells

EBioMedicine, 2016
Dendritic cells (DCs) are major antigen-presenting cells that can efficiently prime and cross-prime antigen-specific T cells. Delivering antigen to DCs via surface receptors is thus an appealing strategy to evoke cellular immunity.
Wenjie Yin, Laurent Gorvel, Sandra Zurawski, Dapeng Li, Ling Ni, Dorothée Duluc, Katherine Upchurch, JongRok Kim, Chao Gu, Richard Ouedraogo, Zhiqing Wang, Yaming Xue, HyeMee Joo, Jean-Pierre Gorvel, Gerard Zurawski, SangKon Oh   +15 more
doaj   +1 more source

Discovering immunoreceptor coupling and organization motifs

Frontiers in Immunology, 2023
The recently determined cryo-EM structures of the T cell antigen receptor (TCR) and B cell antigen receptor (BCR) show in molecular details the interactions of the ligand-binding part with the signaling subunits but they do not reveal the signaling ...
Michael Reth, Michael Reth
doaj   +1 more source

CAR-T Cells: Precision Cancer Immunotherapy

Indonesian Biomedical Journal, 2018
BACKGROUND: Current cancer drugs and treatments are aiming at eradicating tumor cells, but often are more toxic then effective, killing also the normal cells and not selectively the tumor cells.
Anna Meiliana, Nurrani Mustika Dewi, Andi Wijaya   +2 more
doaj   +1 more source

Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation. [PDF]

PLoS ONE, 2008
B-cells integrate antigen-specific signals transduced via the B-cell receptor (BCR) and antigen non-specific co-stimulatory signals provided by cytokines and CD40 ligation in order to produce IgG antibodies.
Francisco J Quintana, Aderet Solomon, Irun R Cohen, Gabriel Nussbaum   +3 more
doaj   +1 more source

Multiplex Identification of Antigen-Specific T Cell Receptors Using a Combination of Immune Assays and Immune Receptor Sequencing

PLoS ONE, 2015
Monitoring antigen-specific T cells is critical for the study of immune responses and development of biomarkers and immunotherapeutics. We developed a novel multiplex assay that combines conventional immune monitoring techniques and immune receptor ...
M. Klinger, F. Pépin, J. Wilkins, Thomas Asbury, T. Wittkop, Jianbiao Zheng, M. Moorhead, M. Faham   +7 more
semanticscholar   +1 more source

Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application

Haematologica, 2008
Background Donor lymphocyte infusion is an effective form of adoptive immunotherapy for hematologic malignancies after allogeneic stem cell transplantation.
Marieke Griffioen, H.M. Esther van Egmond, Helen Barnby-Porritt, Menno A.W.G. van der Hoorn, Renate S. Hagedoorn, Michel G.D. Kester, Nikolai Schwabe, Roel Willemze, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk   +9 more
doaj   +1 more source