Results 71 to 80 of about 836,416 (221)

An Interesting Similarity of Bacillus Calmette-Guerin and Chimeric Antigen Receptor T Cells

Translational Research in Urology, 2020
Intravesical Bacillus Calmette-Guerin (BCG) is approved for non-muscle invasive bladder cancer treatment a long time ago. Chimeric antigen receptor T cells (CAR-Tcell), are T cells are genetically engineered T cells that produce an artificial T-cell ...
Seyed Saeed Tamehri Zadeh, AhmadReza Rezaeian   +1 more
doaj   +1 more source

Tetraspanins as Organizers of Antigen-Presenting Cell Function

Frontiers in Immunology, 2018
Professional antigen-presenting cells (APCs) include dendritic cells, monocytes, and B cells. APCs internalize and process antigens, producing immunogenic peptides that enable antigen presentation to T lymphocytes, which provide the signals that trigger ...
Maria Laura Saiz, Maria Laura Saiz, Vera Rocha-Perugini, Vera Rocha-Perugini, Francisco Sánchez-Madrid, Francisco Sánchez-Madrid, Francisco Sánchez-Madrid   +6 more
doaj   +1 more source

Cholesterol-dependent plasma membrane order (Lo) is critical for antigen-specific clonal expansion of CD4+ T cells

Scientific Reports, 2021
Early “T cell activation” events are initiated within the lipid microenvironment of the plasma membrane. Role of lipid membrane order (Lo) in spatiotemporal signaling through the antigen receptor in T cells is posited but remains unclear.
Soumini Sengupta, Ritesh Karsalia, Amanda Morrissey, Anil K. Bamezai   +3 more
doaj   +1 more source

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones

Journal of Experimental Medicine, 1983
Recent studies suggested that the clonally unique Ti epitopes defined by non-cross-reactive monoclonal antibodies might represent the variable regions of the antigen receptor.
S. Meuer, J. C. Hodgdon, R. Hussey, J. Protentis, S. Schlossman, E. Reinherz   +5 more
semanticscholar   +1 more source

A Systematic Review of the Efforts and Hindrances of Modeling and Simulation of CAR T-cell Therapy [PDF]

arXiv, 2021
Chimeric Antigen Receptor (CAR) T-cell therapy is an immunotherapy that has recently become highly instrumental in the fight against life-threatening diseases. A variety of modeling and computational simulation efforts have addressed different aspects of CAR T therapy, including T-cell activation, T- and malignant cell population dynamics, therapeutic ...
arxiv  

T Cells Can Use Either T Cell Receptor or Cd28 Receptors to Absorb and Internalize Cell Surface Molecules Derived from Antigen-Presenting Cells

Journal of Experimental Medicine, 2000
At the site of contact between T cells and antigen-presenting cells (APCs), T cell receptor (TCR)–peptide–major histocompatibility complex (MHC) interaction is intensified by interactions between other molecules, notably by CD28 and lymphocyte function ...
Inkyu Hwang, Jing-Feng Huang, H. Kishimoto, A. Brunmark, P. A. Peterson, M. Jackson, C. Surh, Z. Cai, J. Sprent   +8 more
semanticscholar   +1 more source

Chimeric Antigen Receptor T-Cell Therapy [PDF]

Journal of the National Comprehensive Cancer Network, 2018
Patients with relapsed or refractory (R/R) cancers have a poor prognosis and limited treatment options. The recent approval of 2 chimeric antigen receptor (CAR) autologous T-cell products for R/R B-cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma treatment is setting the stage for what is possible in other diseases.
Patrick A. Brown, Nancy L. Bartlett, Patricia Kropf, Mara Bloom, Bijal D. Shah, Rebecca A. Gardner, Christine E. Brown, Lauren Gurschick, Steven T. Rosen, Terry J. Fry, Craig S. Sauter, Nicole M. Arwood, Elizabeth J. Shpall, Ndiya Ogba, Elizabeth Lihua Budde, Stephanie Farnia, Robert W. Carlson, Jeff J. Reitan, Morgan Garber   +18 more
openaire   +2 more sources

Immunological recognition by artificial neural networks [PDF]

, 2018
The binding affinity between the T-cell receptors (TCRs) and antigenic peptides mainly determines immunological recognition. It is not a trivial task that T cells identify the digital sequences of peptide amino acids by simply relying on the integrated binding affinity between TCRs and antigenic peptides. To address this problem, we examine whether the
arxiv   +1 more source

HLA-independent T cell receptors for targeting tumors with low antigen density

Nature Network Boston, 2022
J. Mansilla-Soto, Justin Eyquem, Sascha Haubner, Mohamad Hamieh, J. Feucht, Noémie Paillon, A. Zucchetti, Zhuoning Li, Maria Sjöstrand, P. Lindenbergh, M. Saetersmoen, Anton Dobrin, Mathieu Maurin, A. Iyer, Andreina Garcia Angus, Matthew M. Miele, Zeguo Zhao, Theodoros Giavridis, Sjoukje J. C. van der Stegen, Fella Tamzalit, I. Rivière, M. Huse, R. Hendrickson, C. Hivroz, M. Sadelain   +24 more
semanticscholar   +1 more source

T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells

Cancer immunology research, 2016
Bispecific chimeric antigen receptors (CARs) have been systematically optimized to simultaneously target two clinically relevant antigens, CD19 and CD20, presenting a clinically applicable solution to antigen escape and facilitating the rational design ...
Eugenia Zah, Meng-Yin Lin, Anne Silva-Benedict, M. Jensen, Y. Chen   +4 more
semanticscholar   +1 more source