Results 261 to 270 of about 44,035 (314)
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British Journal of Pharmacology, 2021
Background and PurposeThe calcitonin (CT) receptor family is complex, comprising two receptors (the CT receptor [CTR] and the CTR‐like receptor [CLR]), three accessory proteins (RAMPs) and multiple endogenous peptides. This family contains several important drug targets, including CGRP, which is targeted by migraine therapeutics.
Michael L. Garelja +9 more
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Background and PurposeThe calcitonin (CT) receptor family is complex, comprising two receptors (the CT receptor [CTR] and the CTR‐like receptor [CLR]), three accessory proteins (RAMPs) and multiple endogenous peptides. This family contains several important drug targets, including CGRP, which is targeted by migraine therapeutics.
Michael L. Garelja +9 more
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Calcitonin Receptors of Human Osteoclastoma
Hormone and Metabolic Research, 1987Osteoclast-rich cultures were prepared by disaggregation of osteoclastomas (giant cell tumour of bone) and settlement onto glass or plastic surfaces. Autoradiography using [125I]-salmon calcitonin ([125I]-sCT) revealed specific binding only to multinucleate giant cells (osteoclasts) and a minor population of mononuclear cells.
G C, Nicholson +7 more
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Journal of Cellular Biochemistry, 2008
AbstractThe expressions of the calcitonin receptor (CTR), the calcitonin receptor‐like receptor (CLR), the receptor activity‐modifying proteins (RAMP) 1–3, and of the receptor component protein (RCP) have been studied in mouse bone marrow macrophages (BMM) during osteoclast differentiation, induced by treatment with M‐CSF and RANKL.
Susanne, Granholm +2 more
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AbstractThe expressions of the calcitonin receptor (CTR), the calcitonin receptor‐like receptor (CLR), the receptor activity‐modifying proteins (RAMP) 1–3, and of the receptor component protein (RCP) have been studied in mouse bone marrow macrophages (BMM) during osteoclast differentiation, induced by treatment with M‐CSF and RANKL.
Susanne, Granholm +2 more
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Receptors for calcitonin, calcitonin gene related peptide, amylin, and adrenomedullin
Canadian Journal of Physiology and Pharmacology, 1995Calcitonin, calcitonin gene related peptide, amylin, and adrenomedullin are structurally related polypeptides characterized by a six or seven amino acid ring structure linked by a disulfide bridge and an amidated C-terminus. They exhibit overlapping biological actions as a result of cross-reactivity between the different receptors. In this article, the
R, Muff, W, Born, J A, Fischer
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Calcitonin and calcitonin receptors.
Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 2012Calcitonin (CT) is a polypeptide hormone with 32 aminoacids syntetized primarily by the thyroid.Several evidences support the existence of nonthyroidal CT like peptide. The CT gene transcript also encodes a distinct peptide known as calcitonin gene related peptide (CGRP) which is a potent vasodilator and responsible for the stimulation of the ...
Masi, Laura, Brandi, Maria Luisa
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Molecular Pharmacology of the Calcitonin Receptor
Receptors and Channels, 2002The peptide hormone calcitonin is widely used therapeutically in the treatment of bone disorders such as Paget's disease, osteoporosis, and the hypercalcemia of some malignancies. However, emerging evidence suggests the actions of calcitonin via its G protein-coupled receptor, the calcitonin receptor, may not be limited to bone.
Purdue, BW, Tilakaratne, N, Sexton, PM
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Fish calcitonin receptor has novel features
General and Comparative Endocrinology, 2007Calcitonin (CT), a 32-amino acid peptide, was initially isolated from fish. Fish CT has higher affinity to mammalian CT receptor (CTR), and has activity on calcium homeostasis. Therefore, fish CT has been used as a drug for the treatment of human bone diseases.
Nag, K. +5 more
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Calcitonin Receptors of Kidney and Bone
Science, 1972Receptors for calcitonin, determined by activation of adenylate cyclase, were found in a distribution among zones of the kidney distinct from that of receptors for parathyroid hormone or vasopressin. Competitive binding studies showed that the receptors for calcitonin are similar in kidney and bone and that their high apparent affinity for salmon ...
S J, Marx, C J, Woodward, G D, Aurbach
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Molecular and Cellular Endocrinology, 1988
T47D cells possess specific calcitonin (CT) receptors and a CT-responsive adenylate cyclase. Internalization of part of their CT receptors has been suggested. At 37 degrees C, bound 125I-labelled salmon CT (sCT) becomes increasingly resistant to acid washing, which can remove surface-bound hormone, thus indicating internalization.
H G, Schneider +4 more
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T47D cells possess specific calcitonin (CT) receptors and a CT-responsive adenylate cyclase. Internalization of part of their CT receptors has been suggested. At 37 degrees C, bound 125I-labelled salmon CT (sCT) becomes increasingly resistant to acid washing, which can remove surface-bound hormone, thus indicating internalization.
H G, Schneider +4 more
openaire +2 more sources