Results 111 to 120 of about 12,370,091 (268)

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Clinical Review of Calcitonin Gene-Related Peptide Inhibitors for Migraines

, 2023
Migraine is a complex, ubiquitous debilitating neurovascular disorder affecting over one billion people, transcending adult and pediatric populations, gender, and ethnicity.
Martin, Sandrine N.
core   +1 more source

The Anatomy, Histology, and Function of the Major Pelvic Ganglion

Animals
This review provides a comprehensive analysis of the pelvic plexus and its regulation across various mammalian species, including rats, cats, dogs, and pigs.
Jessica Natalia Landa-García, María de la Paz Palacios-Arellano, Miguel Angel Morales, Gonzalo Emiliano Aranda-Abreu, Fausto Rojas-Durán, Deissy Herrera-Covarrubias, María Rebeca Toledo-Cárdenas, Jorge Manuel Suárez-Medellín, Genaro Alfonso Coria-Avila, Jorge Manzo, Maria Elena Hernández-Aguilar   +10 more
doaj   +1 more source

Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges

, 2011
Adrenomedullin (AM), adrenomedullin 2 (AM2/intermedin) and calcitonin gene-related peptide (CGRP) are members of the calcitonin family of peptides. They can act as growth or survival factors for a number of tumours, including those that are endocrine ...
Hay, Deborah, Poyner, DR, Walker, Christopher   +2 more
core   +1 more source

Orofacial pain disorder or trigeminal autonomic cephalalgia? Insights into pathophysiology and implications in medicine and dentistry

Headache: The Journal of Head and Face Pain, EarlyView.
There are some headache disorders known as trigeminal autonomic cephalalgias (TACs). When these “headaches” are localized in the mid‐face region, they are known as “trigeminal autonomic orofacial pains” (TAOPs), and they can mimic other types of face pains including dental pain, which puts the patient at risk of receiving treatments that are incorrect.
Marcela Romero‐Reyes, Simon Akerman
wiley   +1 more source

Subspecialty headache clinic visit reduced healthcare utilization in patients with migraine: Single institution retrospective cohort study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to evaluate whether care in a subspecialty headache center, compared with a general neurology clinic, was associated with lower 90‐day unplanned healthcare utilization (HCU) in patients with migraine and to identify patient‐level factors associated with higher unplanned HCU. Background Migraine is a common, disabling
Megan Trenz, Raja Narendra Divakar Addanki, Jason Raad, Robert Kaniecki, Janel Hanmer, Manisha Jhamb, Wesley T. Kerr, Parthasarathy D. Thirumala   +7 more
wiley   +1 more source

Distribution and target engagement of peripherally administered fremanezumab in the cerebrospinal fluid of healthy volunteers

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Our objective was to describe the distribution of fremanezumab to the cerebrospinal fluid (CSF) in healthy volunteers, and investigate its engagement and stabilization of its target, calcitonin gene‐related peptide (CGRP). Fremanezumab is a CGRP‐targeting monoclonal antibody approved for migraine prevention.
Jacki Rorabaugh, Edward Hellriegel, Juline Bryson, Ryan Tiver, Hang Zeng, Xiaofeng Lu, Steve Barash, Giulia Ghibellini, Olga Szilagyi, Ignacio Echenique, Andrew H. Ahn, Peter J. Goadsby, Laura Rabinovich‐Guilatt   +12 more
wiley   +1 more source

Presence of Calcitonin-gene-related Peptide Receptors Coupled To Adenylate-cyclase in Human Gliomas

, 1994
Eleven surgical samples of gliomas (1 of grade II, 3 of grade III and 7 of grade IV) were analyzed. Calcitonin gene-related peptide (CGRP) receptors were identified by I-125-alpha h-CGRP binding in 9 cases and the presence of a CGRP-stimulated adenylate ...
Woussencolle, MC., Vertongen, P., Deneef, P., Dewitte, O., Brotchi, J., Robberecht, P.   +5 more
core   +2 more sources

Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37)

, 1989
From this study, we predicted that the human calcitonin gene-related peptide (hCGRP) fragment hCGRP-(8-37) would be a selective antagonist for CGRP receptors but an agonist for calcitonin (CT) receptors. In rat liver plasma membrane, where CGRP receptors
T. Chiba, T. Morishita, T. Noda, T. Fujita, T. Yamatani, A. Nakamura, A. Yamaguchi, M. Fukase, T. Inui   +8 more
core   +1 more source

Development of a machine learning (ML) model to predict 3‐month response to CGRP monoclonal antibodies in migraine: A pilot evaluation of physician‐ML model interaction

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary Monoclonal antibodies that target calcitonin gene‐related peptide (CGRP‐mAbs) are effective treatments for preventing migraine in many patients but are expensive, and physicians cannot easily predict which patients will benefit from them.
Masahito Katsuki, Muneto Tatsumoto, Tomokazu Shimazu, Yasuhiko Matsumori, Marina Romozzi, Omid Kohandel Gargari, Alicia Gonzalez‐Martinez, Woo‐Seok Ha, Yutaro Fuse, Shiho Suzuki, Saro Kobayashi, Tomohiko Shiina, Mukuto Shioda, Hiroaki Fujita, Koichi Hirata, Yuya Kano, Ryosuke Fukazawa, Jackson T. S. Cheung, Siobhán O'Connor, Tomás Ward, Kieran Moran, Keisuke Suzuki   +21 more
wiley   +1 more source