Results 121 to 130 of about 12,370,091 (268)

Calcitonin gene-related peptide neurons innervating the canine digestive system

, 1992
Calcitonin gene-related peptide neurons innervating the canine digestive ...
R De Giorgio (9426050), John Furness (13070439), C Sternini (19465366)   +2 more
core  

Novel Peptide Antagonists of Adrenomedullin and Calcitonin Gene-Related Peptide Receptors: Identification, Pharmacological Characterization, and Interactions with Position 74 in Receptor Activity-Modifying Protein 1/3

, 2009
Human adrenomedullin (AM) is a 52-amino acid peptide be-longing to the calcitonin peptide family, which also includes calcitonin gene-related peptide (CGRP) and AM2.
Debbie L. Hay, David R. Poyner, Hay, Debbie L., Jacqueline F. Aitken, Samuel D. Robinson, Richard J. Bailey, Robinson, Samuel D., Aitken, Jacqueline F., Bailey, Richard J., Poyner, David R.   +9 more
core   +1 more source

Headache disorders among Indigenous communities: A scoping review undertaken with knowledge keeper guidance

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective We performed a scoping review of literature on headache etiology, classification, prevalence, and treatment in Indigenous communities in Canada, the United States, Australia, and New Zealand. Background In the United States, analysis of national prevalence indicates that Indigenous Americans lead all other racial/ethnic groups in ...
Maia Kelly, Candice M. Todd, Ojistoh Kahnawahere Horn, Emily Simmonds, Diane Longboat, Cynthia White, Suvendrini Lena   +6 more
wiley   +1 more source

Calcitonin Gene-Related Peptide: Physiology and Pathophysiology

, 2014
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30 years ago, it is produced as a consequence of alternative RNA processing of the calcitonin gene. CGRP has two major forms (α and β).
S. D. Brain, Kodji, X., X. Kodji, Brain, S. D.; id_orcid, Russell, F. A., S.-J. Smillie, Smillie, S. J., F. A. Russell, King, R., R. King   +9 more
core   +1 more source

Pregnancy outcomes following exposure to galcanezumab: Analysis of cases from the galcanezumab clinical trials and postmarketing database

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study was conducted to describe pregnancy outcomes reported following maternal or paternal exposure to galcanezumab in clinical trials and postmarketing surveillance. Background Galcanezumab is a calcitonin gene‐related peptide‐inhibiting monoclonal antibody indicated for the preventive treatment of migraine.
Irene Boz, Jan Lewis Brandes, Christopher Robinson, Maria Fernanda Scantamburlo Fernandes, Sarah Lipsius, LaRonda Morford, Enemona Emmanuel Adaji, Anaclara Prada Jardim, Holland C. Detke   +8 more
wiley   +1 more source

Neuropeptides as regulators of bone metabolism: from molecular mechanisms to traditional Chinese medicine intervention strategies

Frontiers in Pharmacology
Osteoporosis (OP) is a complex bone metabolism disorder disease that affects the skeleton, nervous system, muscles, and multiple tissues. Neuropeptides, which are endogenous substances derived from both bone and brain, play a critical role in maintaining
Qing Lin, Qing Lin, Biyi Zhao, Jiajia Huang, Rumeng Chen, Weipeng Sun, Qianyun Ye, Qianyun Ye, Li Yang, Li Yang, Xiaofeng Zhu, Xiaofeng Zhu, Xiaofeng Zhu, Xiaoyun Li, Xiaoyun Li, Ronghua Zhang, Ronghua Zhang   +16 more
doaj   +1 more source

Comparison between Substance P and Calcitonin Gene-Related Peptide and Their Receptors in Colorectal Adenocarcinoma

Background: Colorectal cancer is a major health problem that still causes many deaths worldwide. Neuropeptides, such as substance P and calcitonin gene-related peptide, play the neurotransmitter and neurohormone roles that increase tumor invasiveness and
Mirela-Marinela Florescu, Mihail Virgil Boldeanu, Cristian Constantin, Robert-Emmanuel Șerban, Mircea-Sebastian Șerbănescu, Mioara-Desdemona Stepan, Lidia Boldeanu, Costin Teodor Streba, Mihaela Ionescu, Vasile-Cosmin Obleagă, Dragoş-Marian Popescu, Cristin Constantin Vere, Dan Nicolae Florescu   +12 more
core   +1 more source

The MIND study: Design, feasibility, and baseline characteristics of a smartphone‐based migraine cohort

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Our objective was to describe the design, feasibility, and baseline characteristics of the Migraine Impact on Neurocognitive Dynamics study, a 30‐day smartphone‐based, prospective, decentralized, observational cohort study evaluating high‐frequency assessment of cognition and symptoms in adults with migraine.
Babak Khorsand, Devin Teichrow, Richard B. Lipton, Ali Ezzati   +3 more
wiley   +1 more source

The Identification of Opioid Receptors and Peptide Precursors in Human DRG Neurons Expressing Pain-Signaling Molecules Confirms Their Potential as Analgesic Targets

Cells
The presence and function of the opioidergic system in sensory dorsal root ganglia (DRG) was demonstrated in various animal models of pain. To endorse recent functional and transcriptional evidence of opioid receptors in human DRG, this study compared ...
Shaaban A. Mousa, Mohammed Shaqura, Sascha Tafelski, Jan David Wandrey, Özgür Celik, Sascha Treskatsch, Michael Schäfer   +6 more
doaj   +1 more source

Longitudinal effects of CGRP‐targeting migraine therapies on blood pressure and body mass index: A 12‐month retrospective analysis

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To compare blood pressure (BP) and body mass index (BMI) trajectories associated with individual calcitonin gene‐related peptide (CGRP)‐targeting migraine therapies versus matched CGRP‐unexposed controls. Background CGRP is a potent vasodilator with established roles in vascular homeostasis and metabolic regulation.
Phillip Phan, Scott Keith, Michael Li, Richard Hass, Wan‐Jen Hsieh, Michael Marmura, Hsiangkuo Yuan   +6 more
wiley   +1 more source