Triptans and CGRP blockade – impact on the cranial vasculature [PDF]
The Journal of Headache and Pain, 2017 The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide (CGRP),
Silvia Benemei +9 more
doaj +5 more sources
CAPA neuropeptides and their receptor form an anti-diuretic hormone signalling system in the human disease vector, Aedes aegypti [PDF]
, 2020 Insect CAPA neuropeptides are homologs of mammalian neuromedin U and are known to influence ion and water balance by regulating the activity of the Malpighian ‘renal’ tubules (MTs).
Ber, Lindsay Taylor +7 more
core +1 more source
The neuropeptide transcriptome of a model echinoderm, the sea urchin Strongylocentrotus purpuratus [PDF]
, 2012 The work reported here was supported by a grant from the University of London Central Research ...
Elphick, MR, Rowe, ML
core +1 more source
Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations
International Journal of Endocrinology, 2020 Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation. This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium release ...
Jingbo Xie +9 more
doaj +1 more source
The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]
, 2013 The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner +13 more
core +2 more sources
Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals
Nature Communications, 2020 Dorsal raphe 5HT(DRSert) neurons regulate arousal from hypercapnia by their projections to the neurons in the external lateral parabrachial nucleus (PBel) that are glutamatergic and also express calcitonin gene related peptide (PBelCGRP).
Satvinder Kaur +10 more
doaj +1 more source
Calcitonin receptor-like receptor is expressed on gastrointestinal immune cells [PDF]
, 2002 Background/Aims: Pharmacological and morphological studies suggest that the gut mucosal immune system and local neuropeptide-containing neurones interact.
Göke, B. +5 more
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Perampanel inhibits calcitonin gene-related peptide release from rat brainstem in vitro
The Journal of Headache and Pain, 2018 Background Perampanel is a novel antiepileptic drug acting via non-competitive antagonism on glutamatergic AMPA receptors, and the subsequent inhibition of ion calcium influx.
Giuseppe Tringali +2 more
doaj +1 more source
Current overview of the role of neuropeptides in ILC2s and future directions
Allergology International, 2022 The neural and immune systems are closely connected, and recently, their molecular mechanisms and relationships with diseases have attracted substantial attention. Particularly, it has been increasingly reported that ILC2s, which produce type 2 cytokines
Misato Irie +3 more
doaj +1 more source
Functional characteristics of calcitonin gene-related peptide receptors in human Ewing's sarcoma WE-68 cells [PDF]
, 1989 Calcitonin gene-related peptide (CGRP) receptor activity was studied in WE-68 human Ewing's sarcoma cells. 125I-human CGRP bound in a time-dependent, reversible and saturable manner.
Andersen +80 more
core +1 more source