Results 191 to 200 of about 33,788 (287)

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

open access: yesExperimental Physiology, Volume 111, Issue 3, Page 653-673, 1 March 2026.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó   +1 more
wiley   +1 more source

Functional expression of inwardly rectifying and ATP‐sensitive potassium channels in human pulmonary artery smooth muscle and endothelial cells

open access: yesThe Journal of Physiology, Volume 604, Issue 5, Page 1820-1839, 1 March 2026.
Abstract figure legend Inwardly rectifying (Kir2) and ATP‐sensitive (KATP) potassium channels are functionally expressed in human pulmonary artery endothelial and smooth muscle cells. The schematic illustrates how Kir2‐ and KATP‐mediated K+ efflux contributes to VM regulation and pulmonary vascular tone.
Bianca Barreira   +7 more
wiley   +1 more source

The pyrogenic mediator prostaglandin E2 elicits warmth seeking via EP3 receptor‐expressing parabrachial neurons: a potential mechanism of chills

open access: yesThe Journal of Physiology, Volume 604, Issue 5, Page 2110-2130, 1 March 2026.
Abstract figure legend During infection, prostaglandin E2 (PGE2) is produced and elicits warmth‐seeking behaviour and involuntary febrile responses by acting on prostaglandin EP3 receptors (EP3Rs) in two distinct brain sites. PGE2 acting on EP3Rs on neurons in the external lateral part of the lateral parabrachial nucleus (LPBel) augments cold sensory ...
Takaki Yahiro   +2 more
wiley   +1 more source

Calcitonin gene-related peptide : isolation, distribution and receptor binding

open access: yes, 1991
Calcitonin gene-related peptide (CGRP) is a 37 amino acid neuropeptide with a potent vasodilatory activity, predicted to result from alternative processing of the primary RNA transcript of calcitonin (CT) gene. The work described in this thesis includes; assay development and validation, isolation and purification of CGRP, and the characterisation of ...
openaire   +1 more source

Endogenous treatments for migraine pain. [PDF]

open access: yesJ Headache Pain
Della Pietra A, Russo AF.
europepmc   +1 more source

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