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Limitations in Using Peptide Drugs to Characterize Calcitonin Gene-Related Peptide Receptors
The Journal of Pharmacology and Experimental Therapeutics, 1999Calcitonin gene-related peptide (CGRP) is an endogenous vasodilator peptide that produces its effects by activation of CGRP1 and CGRP2 receptor subtypes. These receptor subtypes are characterized in functional studies using the agonist Cys(Acm)2, 7-human-alpha-calcitonin gene-related peptide (Cys(ACM)2, 7-h-alpha-CGRP), which activates CGRP2 receptors,
Waugh, D J J +3 more
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Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity
Trends in Endocrinology & Metabolism, 2002Calcitonin gene-related peptide (CGRP) is the most potent vasodilator, and there is a growing body of evidence that this peptide might have multiple other functions. During pregnancy, circulating CGRP levels in rats increase up to the time of delivery, followed by a sharp decline at term and postpartum.
Chandrasekhar, Yallampalli +4 more
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Adrenomedullin and calcitonin gene-related peptide receptors in the rat adrenal cortex
Peptides, 2001The actions of calcitonin gene-related peptide (CGRP) and adrenomedullin on steroid hormone secretion from the rat zona glomerulosa are controversial, with reports in the literature of both stimulatory and inhibitory effects. It appears that these results previously obtained may depend on the nature of the receptors expressed by zona glomerulosa cells.
S, Kapas +3 more
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Capsaicin Receptor as Target of Calcitonin Gene-Related Peptide in the Gut
2014Calcitonin gene-related peptide (CGRP), a 37 aminoacid-residue peptide, is a marker of afferent fibers in the upper gastrointestinal tract, being almost completely depleted following treatment with the selective neurotoxin capsaicin that targets these fibers via transient receptor potential vanilloid type-1 (TRPV-1).
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Calcitonin gene-related peptide receptor antagonists and triptans
Neurology, 2010For both patients and clinicians, triptans—serotonin 5-HT 1B/1D receptor agonists—were to migraine, nearly, what dopamine was to Parkinson disease.1 They provided specific therapy, offering a very substantial clinical improvement, and seemed to offer, in equal measure, insights into the pathophysiology of the disorder.2 However, migraine is complex and
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Receptors for calcitonin gene-related peptide
Neuroscience Research Supplements, 1986Hideyuki Kobayashi +5 more
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Calcitonin gene-related peptide receptor
Trends in Pharmacological Sciences, 1993openaire +1 more source
Calcitonin Gene-Related Peptide (CGRP) and Receptors
2009W. Ma, J.-G. Chabot, R. Quirion
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Distribution of calcitonin gene-related peptide receptors in the lung
European Journal of Pharmacology, 1987openaire +2 more sources