Results 221 to 230 of about 12,370,091 (268)
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Pharmacology of receptors for calcitonin gene-related peptide and amylin
Trends in Pharmacological Sciences, 1995Calcitonin gene-related peptide (CGRP), a widespread neuropeptide with multiple actions, has substantial homology with amylin, a peptide implicated in insulin-resistant diabetes, and adrenomedullin, a recently discovered potent vasodilator. There is controversy over the existence of CGRP receptor subtypes, and whether independent receptors exist for ...
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Calcitonin, calcitonin gene-related peptide and renal calcitonin receptors in the Zucker rat.
Bone and mineral, 1989In this study we investigated (a) whether genetically obese Zucker rats exhibit higher levels of calcitonin gene-related peptide (CGRP) in the thyroid and plasma than lean controls, (b) if CGRP, like calcitonin (CT), increases in plasma in response to iv Ca or iv pentagastrin and (c) whether or not renal CT receptors exhibit 'downregulation' in fat ...
P K, Seitz, C W, Cooper
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Regulation of signal transduction by calcitonin gene-related peptide receptors
Trends in Pharmacological Sciences, 2010Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct assembly, made up of a G protein-coupled receptor (GPCR), a single transmembrane protein, and an additional protein that is required for Gα(s) coupling.
Christopher S, Walker +3 more
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Calcitonin gene-related peptide receptor antagonists for migraine
Expert Opinion on Investigational Drugs, 2010Migraine is a highly prevalent disabling condition, and the current treatment options are not satisfactory. The role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology is well established. CGRP receptor antagonists address this new target and have the potential to improve therapy for both responders and non-responders to previous ...
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Calcitonin gene-related peptides and their receptors
1999Calcitonin gene-related peptide (CGRP) is an abundant 37 amino acid neuropeptide which was discovered in 1982 [1]. It is an extremely potent vasodilator, causing noticeable effects on the human forearm when given in femtomole quantities [2]. The peptide is found as two variants, α-and β-CGRP, but these differ only by three amino acids in man, and the ...
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Specific Receptor and Cardiovascular Effects of Calcitonin Gene-Related Peptide*
Endocrinology, 1986Specific binding sites for calcitonin gene-related peptide (CGRP) were demonstrated in the rat heart and spleen. Autoradiography revealed rat [125I]iodo CGRP binding associated with the intima and media of the aorta, the coronary arteries and the heart valves, and the red pulp of the spleen.
S, Sigrist +5 more
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Isolation, purification, and characterization of calcitonin gene-related peptide receptor
Peptides, 1993Intact calcitonin gene-related peptide (CGRP) receptors were solubilized from porcine neural membranes using sodium cholate: potassium buffer. The solubilized receptors were purified sequentially by hydrophobic interaction and ion-exchange chromatography followed by specific affinity chromatography.
S J, Wimalawansa +2 more
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Macrophages express functional receptors for calcitonin‐gene‐related peptide
Journal of Cellular Physiology, 1991AbstractThe present study was designed to investigate whether non‐activated macrophages express calcitonin (CT) or calcitonin‐gene‐related peptide (CGRP) receptors. To this end, we first analyzed whether CT and CGRP induce a cAMP accumulation in macrophages.
A, Vignery, F, Wang, M B, Ganz
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American Journal of Obstetrics and Gynecology, 1998
Our purpose was to investigate (1) whether uterine relaxation responses to calcitonin gene-related peptide are differentially regulated during pregnancy and labor, (2) the involvement of nitric oxide in smooth muscle relaxant action of calcitonin gene-related peptide in the rat uterus, (3) whether receptors for calcitonin gene-related peptide are ...
Y L, Dong +4 more
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Our purpose was to investigate (1) whether uterine relaxation responses to calcitonin gene-related peptide are differentially regulated during pregnancy and labor, (2) the involvement of nitric oxide in smooth muscle relaxant action of calcitonin gene-related peptide in the rat uterus, (3) whether receptors for calcitonin gene-related peptide are ...
Y L, Dong +4 more
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Activities of calcitonin gene-related peptide (CGRP) and related peptides at the CGRP receptor
Peptides, 1990In guinea pig pancreatic acini rat calcitonin gene-related peptide (CGRP) increased amylase release 2-fold, salmon calcitonin had an efficacy of only 44% of that of CGRP and [Tyr0]CGRP(28-37) and human calcitonin had no actions. [Tyr0]CGRP(28-37), but not human calcitonin, antagonized the actions of CGRP in pancreatic acini with an IC50 of 3 microM ...
P N, Maton +4 more
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