CGRP Receptor Family and Accessory Protein Localization: Implications for Predicted Function
The Scientific World Journal, 2001 Calcitonin gene-related peptide (CGRP), adrenomedullin, amylin, and calcitonin are functionally related neuropeptides. Certain of these peptides mediate their action through receptors which have common components, such as the receptor activity modifying ...
K.R. Oliver
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A Native PAGE Assay for the Biochemical Characterization of G Protein Coupling to GPCRs
Bio-Protocol, 2021 G protein-coupled receptors (GPCRs) are a large family of membrane-embedded receptors that have diverse roles in physiology and are major drug targets. GPCRs transduce an agonist binding signal across the membrane to activate intracellular heterotrimeric
Amanda Roehrkasse +2 more
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Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest [PDF]
, 2018 Hylobius abietis (Linnaeus), or large pine weevil (Coleoptera, Curculionidae), is a pest of European coniferous forests. In order to gain understanding of the functional physiology of this species, we have assembled a de novo transcriptome of H. abietis,
Davies, Shireen-Anne +7 more
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Recent advances in targeting calcitonin gene-related peptide for the treatment of menstrual migraine
Medicine, 2022 . Menstrual migraine (MM) has a longer duration and higher drug resistance than non-perimenstrual migraine. Calcitonin gene-related peptide (CGRP) and CGRP receptors are expressed in the peripheral and central nervous systems throughout the ...
Yan Jiang, MMed, Zhen-Lun Huang, BMed
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The binding of botulinum neurotoxins to different peripheral neurons [PDF]
, 2017 Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality.
Rossetto, O.
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The Scientific World Journal, 2001 CGRP, AM, amylin, and CT have in common N-terminal 6-7 amino acid ring structures linked by disulfide bridges and amidated C-termini required for biological activity.
J.A. Fischer, W. Born, R. Muff
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IBRO Neuroscience Reports, 2022 The trigeminal ganglion is implicated in the underlying pathology of migraine and temporomandibular joint disorders (TMD), which are orofacial pain conditions involving peripheral and central sensitization.
Sophia R. Antonopoulos, Paul L. Durham
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Antagonism of CGRP Signaling by Rimegepant at Two Receptors
Frontiers in Pharmacology, 2020 The “gepants” are a class of calcitonin gene-related peptide (CGRP) receptor antagonist molecules that have been developed for the prevention and treatment of migraine.
Kylie S. Pan +8 more
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Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37) [PDF]
American Journal of Physiology-Endocrinology and Metabolism, 1989 From this study, we predicted that the human calcitonin gene-related peptide (hCGRP) fragment hCGRP-(8-37) would be a selective antagonist for CGRP receptors but an agonist for calcitonin (CT) receptors. In rat liver plasma membrane, where CGRP receptors predominate and CT appears to act through these receptors, hCGRP-(8-37) dose dependently displaced ...
T, Chiba +8 more
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Receptor activity modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors [PDF]
, 2016 The calcitonin gene-related peptide (CGRP) family of G protein-coupled receptors (GPCRs) is formed through association of the calcitonin receptor-like receptor (CLR) and one of three receptor activitymodifying proteins (RAMPs).
Weston, Cathryn +11 more
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