Calcitriol-Mediated Hypercalcemia, Somatostatin Receptors Expression and 25-Hydroxyvitamin D3-1α- Hydroxylase in GIST Tumors [PDF]
Frontiers in Endocrinology, 2022 Hypercalcemia is a common complication in cancer patients Mainly caused by Parathyroid hormone-related protein (PTHrP) secretion and metastasis. Calcitriol secretion is a rare source of hypercalcemia in solid tumors, especially in gastrointestinal ...
Yiraldine Herrera-Martínez +22 more
doaj +5 more sources
Calcitriol and Tacalcitol Modulate Th17 Differentiation Through Osteopontin Receptors: Age-Dependent Insights from a Mouse Breast Cancer Model [PDF]
ImmunoTargets and TherapyAleksandra Strzykalska-Augustyniak, Mateusz Psurski, Honorata Zachary, Beata Filip-Psurska, Dagmara Kłopotowska, Magdalena Milczarek, Marta Świtalska, Martyna Stachowicz-Suhs, Natalia Łabęd&zacute ...
Strzykalska-Augustyniak A +11 more
doaj +4 more sources
Presence and binding characteristics of calcitriol receptors in human fetal gut [PDF]
FEBS Letters, 1990 In the present study, we show for the first time the presence of calcitriol‐specific binding sites in hypertonic extracts of cells isolated from human fetal small intestine and colon from 13–21 weeks of gestation. Woolf plot analysis of the binding characteristics revealed the presence of a single class of high affinity receptors.
Delvin, Edgard E. +3 more
openaire +3 more sources
SARS-CoV-2 infection induces functional impairment of vitamin D receptor signaling to drive interleukin 6-dependent hyperinflammation in mononuclear phagocytes. [PDF]
PLoS ONEThe dysregulated inflammatory response, particularly the interleukin 6 (IL-6)-driven cytokine storm, is a hallmark of severe COVID-19. Mononuclear phagocytes are key cellular populations in the pathogenesis of SARS-CoV-2 infection, but the underlying ...
Juan Felipe Valdés-López +8 more
doaj +2 more sources
Management of osteoporosis with calcitriol in elderly Chinese patients: a systematic review
Clinical Interventions in Aging, 2014 Ruo-xi Liao, Miao Yu, Yan Jiang, Weibo XiaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, and Chinese Academy of Medical Sciences, Beijing, People's Republic of ChinaAbstract ...
Liao RX, Yu M, Jiang Y, Xia WB
doaj +1 more source
Role of Calcitriol and Vitamin D Receptor (VDR) Gene Polymorphisms in Alzheimer’s Disease
International Journal of Molecular SciencesAlzheimer’s disease (AD) is characterized by amyloid beta (Aβ) buildup and neuronal degeneration. An association between low serum vitamin D levels and an increased risk of AD has been reported in several epidemiological studies. Calcitriol (1,25-dihydroxycholecalciferol) is the active form of vitamin D, and is generated in the kidney and many other ...
Soon Pyo Jeong +2 more
openaire +3 more sources
Study of Calcitriol Interaction with the Vitamin D Receptor Using DFT and TD-DFT Calculations. [PDF]
J Phys Chem BCalcitriol, the primary active metabolite of vitamin D, has garnered significant re- search interest due to its role in various pathologies, including cancer, tuberculosis, and sclerosis. However, excessive calcitriol levels or heightened sensitivity of the vitamin D receptor (VDR) to this compound can lead to hypercalcemia.
Miranda VR, Morgon NH.
europepmc +3 more sources
, 2023 Osteoarthritis (OA) is characterized by the lubrication dysfunction of a cartilage sliding interface caused by chronic joint inflammation, and effective nonsurgical therapy for advanced OA remains lacking.
Huiwen Lu (16383797) +11 more
core +3 more sources
Vitamin D, vitamin D binding protein, vitamin D receptor levels and cardiac dysautonomia in patients with multiple sclerosis: a cross-sectional study [PDF]
Arquivos de Neuro-Psiquiatria, 2020 Vitamin D is a pleiotropic steroid hormone that modulates the autonomic balance. Its deficiency has been described as an environmental risk factor for multiple sclerosis (MS).
Tülin Aktürk +5 more
doaj +1 more source
Antibodies, 2021 Chronic joint inflammation due to increased secretion of pro-inflammatory cytokines, the accumulation of inflammatory immune cells (mainly macrophages), and vitamin D deficiency leads to cartilage degeneration and the development of osteoarthritis (OA ...
Vikrant Rai +2 more
doaj +1 more source