Results 11 to 20 of about 9,580 (229)
Presence and binding characteristics of calcitriol receptors in human fetal gut
FEBS Letters, 1990 In the present study, we show for the first time the presence of calcitriol-specific binding sites in hypertonic extracts of cells isolated from human fetal small intestine and colon from 13–21 weeks of gestation.
Delvin, Edgard E. +7 more
core +3 more sources
Effect of Schiff base formation on the function of the calcitriol receptor
Kidney International, 1996 Effect of Schiff base formation on the function of the calcitriol receptor. The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes.
Patel, Sanjeevkumar R. +2 more
core +3 more sources
Journal of Immunology Research, 2019 Triple-negative breast cancer (TNBC) is one of the most aggressive tumors, with poor prognosis and high metastatic capacity. The aggressive behavior may involve inflammatory processes characterized by deregulation of molecules related to the ...
Isela Martínez-Reza +7 more
doaj +2 more sources
Management of osteoporosis with calcitriol in elderly Chinese patients: a systematic review
Clinical Interventions in Aging, 2014 Ruo-xi Liao, Miao Yu, Yan Jiang, Weibo XiaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, and Chinese Academy of Medical Sciences, Beijing, People's Republic of ChinaAbstract ...
Liao RX, Yu M, Jiang Y, Xia WB
doaj +1 more source
Role of Calcitriol and Vitamin D Receptor (VDR) Gene Polymorphisms in Alzheimer’s Disease
International Journal of Molecular SciencesAlzheimer’s disease (AD) is characterized by amyloid beta (Aβ) buildup and neuronal degeneration. An association between low serum vitamin D levels and an increased risk of AD has been reported in several epidemiological studies. Calcitriol (1,
Niti Sharma +2 more
core +3 more sources
PharmaceuticalsDepression and anxiety disorders, prevalent neuropsychiatric conditions that frequently coexist, limit psychosocial functioning and, consequently, the individual’s quality of life.
Bruna R. Kouba +2 more
doaj +2 more sources
Кардиоваскулярная терапия и профилактика, 1970 Aim. To study the role of vitamin D in the prevention and treatment of cardio-renal syndrome (CRS), chronic allograft nephropathy (CAN), as well as in the renal and cardiac tissue reparation. Material and methods.
A. N. Kharlamov +4 more
doaj +2 more sources
Calcitriol Induces Paraoxonase 1 Expression in HepG2 Cells: Possible Involvement of VDR-Dependent and Alternative Pathways. [PDF]
Int J Mol SciParaoxonase 1 (PON1) is an antioxidant enzyme that plays physio-pathological roles. Prior in silico analysis revealed the presence of response elements of the nuclear receptor superfamily in the PON1 promoter, comparable to glucocorticoid receptors (GR),
Navarro-García F +10 more
europepmc +2 more sources
Study of Calcitriol Interaction with the Vitamin D Receptor Using DFT and TD-DFT Calculations. [PDF]
J Phys Chem BCalcitriol, the primary active metabolite of vitamin D, has garnered significant research interest due to its role in several pathologies. However, excessive calcitriol levels or heightened sensitivity of the vitamin D receptor (VDR) can lead to hypercalcemia, motivating the search for analogues that preserve therapeutic activity while reducing adverse
Miranda VR, Morgon NH.
europepmc +3 more sources
Rapid nontranscriptional effects of calcifediol and calcitriol [PDF]
, 2022 Classically, a secosteroid hormone, vitamin D, has been implicated in calcium and phosphate homeostasis and has been associated with the pathogenesis of rickets and osteomalacia in patients with severe nutritional vitamin D deficiency.
Cinzia Aurilia +13 more
core +1 more source